| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Outline of Final Research Achievements |
In this project, we aimed to obtain mechanistic insights on the Ca2+/calmodulin-dependent information “writing” process that neurons utilize in the living brain. To address this, 1) we developed new improved Ca2+ signaling sensors, and 2) took advantage of these tools to dissect the spread and information processing encoded by Ca2+ signals and Ca2+ effector activation. Furthermore, we investigated the role of Ca2+/calmodulin-dependent signaling in long-term memory consolidation, and identified several new key molecular players involved in this process. These results shed new light on basic principles on how the brain works, and epitomizes the urgent need to developing foundational technologies to record and manipulate brain functions.
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