|Budget Amount *help
¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2015: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
|Outline of Final Research Achievements
We addressed how neuronal growth is controlled by nutritional status using Class IV dendritic arborization neurons in Drosophila larvae. We found that dendritic arbors of Class IV neurons became more complex when larvae were reared on a low-yeast diet, which contains lower amounts of amino acids and other ingredients, compared to a high-yeast diet. We also showed that mitochondrial dysfunction triggers dendritic loss in a manner dependent on eIF2α phosphorylation and translation inhibition.