| Budget Amount *help |
¥39,520,000 (Direct Cost: ¥30,400,000、Indirect Cost: ¥9,120,000)
Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2015: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
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| Outline of Final Research Achievements |
ertebrate can be characterized by the posession of head mesoderm. Through the study using amphioxus, an animal with no head mesoderm, we found that the head mesoderm was obtained by topographical shift of early mesoderm, and by suppression of this shift, we showed that amphioxus-like mesoderm could be partially phenocopied in vertebrate embryos.
Cyclostomes were employed for the study of hypobranchial muscle (HBM) development. Through comparative embryological observation and cell lineage analyses, we found that the deep position of the gnathostome HBM arose as the result of the shift of relative positions between the pharynx and pericardium. In the ongoing study using elasmobranch (shark) embryos, we have so far found that two paralogues of Lbx genes are diferentially expressed in the anterior and posterior portions of the HBM primordia. Of those, cyclostome HBM resemble more the posterior. We suspect gene duplication behind the novel patterns of muscle.
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