Analysis and application of lipid metabolisms in gut microorganisms for creation of novel functional lipids
| Project/Area Number |
15H02441
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
Jun Ogawa 京都大学, 農学研究科, 教授 (70281102)
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| Co-Investigator(Kenkyū-buntansha) |
後藤 剛 京都大学, 農学研究科, 准教授 (10550311)
岸野 重信 京都大学, 農学研究科, 助教 (40432348)
菅原 達也 京都大学, 農学研究科, 教授 (70378818)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2017: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2016: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2015: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
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| Keywords | 腸内細菌 / 脂質代謝 / 乳酸菌 / 機能性脂質 / プロバイオティクス / プロバイティクス |
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| Outline of Final Research Achievements |
Polyunsaturated fatty acids derived from dietary lipids were found to be saturated by gut microbes with hydroxy, oxo, and conjugated fatty acids as intermediates. We confirmed the existence of these fatty acids in host tissues depending on the existence of gut microbes and evaluated their physiological activity. An initial hydroxy fatty acid metabolite of linoleic acid, contributed to recovery from damage to the intestinal epithelial barrier. Furthermore, hydroxy fatty acids and oxo fatty acids controlled host metabolisms and physiologies through interactions with nuclear receptors, such as PPARs and LXR, TRPV1 and GPRs (GPR40 and GPR120). These observations suggest that the fatty acid molecular species formed specifically in the intestinal tract by gut microbial metabolism can influence the health of the host. These findings revealed that it is possible to enhance health by controlling gut microbial fatty acid metabolism and the fatty acid composition of dietary lipids.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Production of dicarboxylic acids from novel unsaturated fatty acids by laccase-catalyzed oxidative cleavage2016
Author(s)
Takeuchi, M., S. KIishino, S.B. Park, N. Kitamura, H, Watanabe, A. Saika, M. Hibi, K. Yokozeki, J. Ogawa
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: 80(11)
Issue: 11
Pages: 2132-2137
DOI
Related Report
Peer Reviewed
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[Journal Article] 長鎖不飽和脂肪酸とその腸内細菌代謝物によるGPR120活性化の検討2016
Author(s)
本郷翔子, 森本育美, 山上小百合, 古田美咲, 滝澤祥恵, 井上飛鳥, 青木淳賢, 東山繁樹, 吉田守克, 宮里幹也, 岸野重信, 小川 順, 中田理恵子, 井上裕康
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Journal Title
脂質生化学研究
Volume: 58
Pages: 53-54
Related Report
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[Journal Article] 10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress2016
Author(s)
Furumoto, H., T. Nanthirudjanar, T. Kume, Y. Izumi, S.B. Park, N. Kitamura, S. Kishino, J. Ogawa, T. Hirata, T. Sugawara
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Journal Title
Toxicol. Appl. Pharmacol.
Volume: 296
Pages: 1-9
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Gut microbial fatty acid metabolites reduce triacylglycerol levels in hepatocytes2015
Author(s)
Nanthirudjanar, T., H. Furumoto, J. Zheng, Y.L. Kim, T. Goto, N. Takahashi, T. Kawada, S.B. Park, A. Hirata, N. Kitamura, S. Kishino, J. Ogawa, T. Hirata, T. Sugawara
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Journal Title
Lipids
Volume: 50
Issue: 11
Pages: 1093-1102
DOI
NAID
Related Report
Peer Reviewed
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