• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Brain-gut axis mechanisms formed by mother-pup interactions for the resilience to stress

Research Project

Project/Area Number 15H02479
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Integrative animal science
Research InstitutionAzabu University

Principal Investigator

Kikusui Takefumi  麻布大学, 獣医学部, 教授 (90302596)

Co-Investigator(Kenkyū-buntansha) 大野 博司  国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (50233226)
茂木 一孝  麻布大学, 獣医学部, 准教授 (50347308)
宮内 栄治  国立研究開発法人理化学研究所, 生命医科学研究センター, 基礎科学特別研究員 (60634706)
森田 英利  岡山大学, 環境生命科学研究科, 教授 (70257294)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000)
Fiscal Year 2018: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2017: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2016: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2015: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Keywordsマウス / 母子間 / ストレス / 腸内細菌叢 / 免疫 / 細菌叢 / うう様行動 / 早期離乳 / BDNF / 内分泌 / 腸内免疫 / グルココルチコイド / 母性 / 中枢 / 前頭葉
Outline of Final Research Achievements

In early weaning mice, fear extinction learning was impaired, and BDNFIII mRNA and BDNF protein in the frontal lobe decreased. A negative correlation was also found between them, and it was postulated that the resistance to extinction of fear memory by early weaning involves the attenuation of the BDNF action through the decrease in expression of BDNFIII mRNA in the frontal lobe. Furthermore, it was shown that feces of early weaning mice usually show a different bacterial flora from weaning, and that changes in the bacterial flora are involved in depression-like behavior. In parallel, changes in the intestinal immunoplexus centered, such as Tregs were also confirmed. In addition, experiments to establish the bacterial flora in germ-free mice have shown that the bacterial flora of early weaning mice increased depression behavior and was related to an increase in interindividual distance and a decrease in BDNF in the intracerebral lobe.

Academic Significance and Societal Importance of the Research Achievements

幼少期の環境が、個体の成長に与える影響、特に不安行動や社会性の障害における影響は、動物に限らずヒト社会でも危急の課題である。今回の研究で、1)幼少期環境は前頭葉の神経栄養因子の発達に特異的なエピジェネティック変化を及ぼすこと、3)並行して腸内細菌叢と免疫系の変化が認められること、4)腸内細菌叢の変化自体が、中枢発達に強い影響を与えること、5)腸内細菌叢を改善することで幼少期ストレスの効果を軽減させる可能性があること、が見いだされた。幼児虐待が増加の一途をたどる現代日本において、その分子生物学的な機序の解明は新たな予防法や治療法に資する成果といえる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (59 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (27 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 27 results,  Open Access: 20 results,  Acknowledgement Compliant: 4 results) Presentation (25 results) (of which Invited: 7 results) Book (3 results) Remarks (2 results)

  • [Int'l Joint Research] Albert Einstein College of Medicine(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] McGill university(Canada)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Early weaning increases anxiety via brain-derived neurotrophic factor signaling in the mouse prefrontal cortex2019

    • Author(s)
      Kikusui Takefumi、Kanbara Natsumi、Ozaki Mariya、Hirayama Nozomi、Ida Kumiko、Tokita Mika、Tanabe Naho、Mitsuyama Kuriko、Abe Hatsuki、Yoshida Miki、Nagasawa Miho、Mogi Kazutaka
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3991-3991

    • DOI

      10.1038/s41598-019-40530-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gonadal steroid hormone secretion during the juvenile period depends on host-specific microbiota and contributes to the development of odor preference2019

    • Author(s)
      Kamimura Itsuka、Watarai Akiyuki、Takamura Takuma、Takeo Atsushi、Miura Kyoko、Morita Hidetoshi、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      Developmental Psychobiology

      Volume: in press Issue: 5 Pages: 670-678

    • DOI

      10.1002/dev.21827

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Responses to pup vocalizations in subordinate naked mole-rats are induced by estradiol ingested through coprophagy of queen’s feces2018

    • Author(s)
      Watarai Akiyuki、Arai Natsuki、Miyawaki Shingo、Okano Hideyuki、Miura Kyoko、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 37 Pages: 9264-9269

    • DOI

      10.1073/pnas.1720530115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Female mice exhibit both sexual and social partner preferences for vocalizing males2018

    • Author(s)
      NOMOTO Kensaku、IKUMI Mayu、OTSUKA Monami、ASABA Akari、KATO Masahiro、KOSHIDA Nobuyoshi、MOGI Kazutaka、KIKUSUI Takefumi
    • Journal Title

      Integrative Zoology

      Volume: 13 Issue: 6 Pages: 735-744

    • DOI

      10.1111/1749-4877.12357

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex differences in olfactory-induced neural activation of the amygdala.2018

    • Author(s)
      Kikusui T, Kajita M, Otsuka N, Hattori T, Kumazawa K, Watarai A, Nagasawa M, Inutsuka A, Yamanaka A, Matsuo N, Covington HE 3rd, Mogi K.
    • Journal Title

      Behav Brain Res.

      Volume: 27 Pages: 96-104

    • DOI

      10.1016/j.bbr.2017.11.034

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Sociosexual Experience and Aging on Number of Courtship Ultrasonic Vocalizations in Male Mice2018

    • Author(s)
      Kanno Kouta、Kikusui Takefumi
    • Journal Title

      Zoological Science

      Volume: 35 Issue: 3 Pages: 208-214

    • DOI

      10.2108/zs170175

    • NAID

      40021616693

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of the Oxytocin Receptor Gene Polymorphism on Successful Training for Drug Detection Dogs.2018

    • Author(s)
      Konno A, Yabuta S, Inoue-Murayama M, Tonoike A, Nagasawa M, Mogi K, Kikusui T
    • Journal Title

      Journal of Heredity

      Volume: - Issue: 5 Pages: 0-0

    • DOI

      10.1093/jhered/esy012

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of an Intra- and Inter-specific Tear Protein Signal in Rodents2018

    • Author(s)
      Tsunoda Mai、Miyamichi Kazunari、Eguchi Ryo、Sakuma Yasuo、Yoshihara Yoshihiro、Kikusui Takefumi、Kuwahara Masayoshi、Touhara Kazushige
    • Journal Title

      Current Biology

      Volume: 28 Issue: 8 Pages: 1213-1223

    • DOI

      10.1016/j.cub.2018.02.060

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] How does social enrichment produce health benefits?2018

    • Author(s)
      Kikusui Takefumi
    • Journal Title

      eLife

      Volume: 7

    • DOI

      10.7554/elife.43666

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal Responsible for the Bruce Effect in Mice.2017

    • Author(s)
      Hattori T, Osakada T, Masaoka T, Ooyama R, Horio N, Mogi K, Nagasawa M, Haga-Yamanaka S, Touhara K, Kikusui T.
    • Journal Title

      Curr Biol.

      Volume: 27 Issue: 20 Pages: 3197-3201

    • DOI

      10.1016/j.cub.2017.09.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intranasal Oxytocin Treatment Increases Eye-Gaze Behavior toward the Owner in Ancient Japanese Dog Breeds.2017

    • Author(s)
      M. Nagasawa, M. Ogawa, K. Mogi, T. Kikusui
    • Journal Title

      Frontiers in Psychology

      Volume: 8 Pages: 1624-1624

    • DOI

      10.3389/fpsyg.2017.01624

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses2017

    • Author(s)
      K. Inokuchi, F. Imamura, H. Takeuchi, R. Kim, H. Okuno, H. Nishizumi, H. Bito, T. Kikusui, H. Sakano
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 15977-15977

    • DOI

      10.1038/ncomms15977

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT2017

    • Author(s)
      H. Saito, H. Nishizumi, S. Suzuki, H. Matsumoto, N. Ieki, T. Abe, H. Kiyonari, M. Morita, H. Yokota, N. Hirayama, T. Yamazaki, T. Kikusui, K. Mori, H. Sakano
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 16011-16011

    • DOI

      10.1038/ncomms16011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity.2017

    • Author(s)
      A. Asaba, T. Osakada, K. Touhara, M. Kato, T. K. Mogi, T. Kikusui
    • Journal Title

      Hormones and Behavior

      Volume: 94 Pages: 53-60

    • DOI

      10.1016/j.yhbeh.2017.06.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Faecal transplantation for the treatment of Clostridium difficile infection in a marmoset2017

    • Author(s)
      Yamazaki Yumiko、Kawarai Shinpei、Morita Hidetoshi、Kikusui Takefumi、Iriki Atsushi
    • Journal Title

      BMC Veterinary Research

      Volume: 13 Issue: 1 Pages: 150-150

    • DOI

      10.1186/s12917-017-1070-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emotional changes induced by social stress in juvenile period2017

    • Author(s)
      T. Kikusui, K. Mogi
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 149 Issue: 2 Pages: 66-71

    • DOI

      10.1254/fpj.149.66

    • NAID

      130005306342

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutual mother-infant recognition in mice: the role of pup ultrasonic vocalizations2017

    • Author(s)
      Mogi K, Takakuda A, Tsukamoto C, Oyama R, Okabe S, Koshida N, Nagasawa M, Kikusui T.
    • Journal Title

      Behav Brain Res.

      Volume: 325 Pages: 138-146

    • DOI

      10.1016/j.bbr.2016.08.044

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Self-Generated Environmental Factor as a Potential Contributor to Atypical Early Social Communication in Autism2017

    • Author(s)
      Kikusui T, Hiroi N
    • Journal Title

      Neuropsychopharmacology.

      Volume: 42 Issue: 1 Pages: 378-378

    • DOI

      10.1038/npp.2016.225

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice2017

    • Author(s)
      Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., Kuroda, M., Koide, T., Kikusui, T.
    • Journal Title

      Psychoneuroendocrinology

      Volume: 79 Pages: 20-30

    • DOI

      10.1016/j.psyneuen.2017.01.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-Exposure to the Male Pheromone ESP1 Enhances Male Aggressiveness in Mice2016

    • Author(s)
      Tatsuya Hattori, Takuya Osakada, Ayaka Matsumoto, Naoki Matsuo, Sachiko Haga-Yamanaka, Takaya Nishida, Yuji Mori, Kazutaka Mogi, Kazushige Touhara, Takefumi Kikusui
    • Journal Title

      Current Biology

      Volume: 26 Issue: 9 Pages: 1229-1234

    • DOI

      10.1016/j.cub.2016.03.029

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early weaning impairs fear extinction and decreases brain-derived neurotrophic factor expression in the prefrontal cortex of adult male C57BL/6 mice2016

    • Author(s)
      Kazutaka Mogi, Yuiko Ishida, Miho Nagasawa, Takefumi Kikusui.
    • Journal Title

      Dev Psychobiol.

      Volume: 58 Issue: 8 Pages: 1034-1042

    • DOI

      10.1002/dev.21437

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Early weaning impairs a social contagion of pain-related stretching behavior in mice.2016

    • Author(s)
      Takefumi Kikusui, Yukino Ishio, Miho Nagasawa, Jeffrey Mogil, Kazutaka Mogi.
    • Journal Title

      Dev Psychobiol

      Volume: 58 Issue: 8 Pages: 1101-1107

    • DOI

      10.1002/dev.21443

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Early weaning influences short-term synaptic plasticity in the medial prefrontal-anterior basolateral amygdala pathway2016

    • Author(s)
      Takita M, Kikusui T
    • Journal Title

      Neuroscience Research

      Volume: 103 Pages: 48-53

    • DOI

      10.1016/j.neures.2015.08.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structure and function of neonatal social communication in a genetic mouse model of autism.2016

    • Author(s)
      T. Takahashi, S. Okabe, P. Ó Broin, A. Nishi, K. Ye, M. V. Beckert, T. Izumi, A. Machida, G. Kang, Seiji Abe, J. L. Pena, A. Golden, T. Kikusui, N. Hiroi.
    • Journal Title

      Molecular Psychiatry

      Volume: in press Issue: 9 Pages: 1-7

    • DOI

      10.1038/mp.2015.190

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of behavioral characteristics of dogs in the United States and Japan2016

    • Author(s)
      Miho Nagasawa, Kazutaka Mogi, James Serpell, and Takefumi Kikusui
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 2 Pages: 231-238

    • DOI

      10.1292/jvms.15-0253

    • NAID

      130005131341

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Draft genome sequence of Bifidobacterium aesculapii DSM 26737T isolated from feces of baby common marmoset.2015

    • Author(s)
      Hidehiro Toh, Yumiko Yamazaki, Kosuke Tashiro, Shinpei Kawarai, Kenshiro. Oshima, Akiyo Nakano, Co Nguyen Thi Kim, Iyo Mimura, Kensuke Arakawa, Atsushi Iriki, Takefumi Kikusui, Hidetoshi Morita.
    • Journal Title

      Genome Announcements

      Volume: 3 Issue: 6

    • DOI

      10.1128/genomea.01463-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of owner-reported behavioral characteristics among genetically clustered breeds of dog (Canis familiaris).2015

    • Author(s)
      Tonoike, A., Nagasawa, M., Mogi, K., Serpell, J. A., Ohtsuki, H., Kikusui, T.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 17710-17710

    • DOI

      10.1038/srep17710

    • NAID

      120006667789

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 社会内分泌学2018

    • Author(s)
      菊水健史
    • Organizer
      京都大学霊長類研究所大学院集中講義
    • Related Report
      2018 Annual Research Report
  • [Presentation] オスマウス超音波発声スペクトラムを制御する内分泌-神経回路の同定2018

    • Author(s)
      菊水健史
    • Organizer
      新学術「性スペクトラム」第2回領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒトとイヌの絆ー視線を用いたコミュニケーションー2018

    • Author(s)
      菊水健史
    • Organizer
      日本臨床獣医学フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 自閉症モデルマウスにおけるコミュニケーション能力の解析2018

    • Author(s)
      *加藤梨沙・町田暁洋・野元謙作・廣井昇・茂木一孝・菊水健史
    • Organizer
      第29回日本行動神経内分泌研究会(JSBN)
    • Related Report
      2018 Annual Research Report
  • [Presentation] イヌの視線を介したコミュニケーションに関わる遺伝的基盤について2018

    • Author(s)
      *荒田明香・武内萌花・大滝賢一・外池亜紀子・永澤美保・茂木一孝・菊水健史
    • Organizer
      第29回日本行動神経内分泌研究会(JSBN)
    • Related Report
      2018 Annual Research Report
  • [Presentation] ストレスを受けた母マウスの仔マウス保護行動は内側前頭前皮質から視床室傍核への投射細胞によって抑制される2018

    • Author(s)
      *目黒拓也・度会晃行・犬束歩・茂木一孝 ・菊水健史
    • Organizer
      第29回日本行動神経内分泌研究会(JSBN)
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス長期個体追跡による集団行動解析2018

    • Author(s)
      *野元謙作・田嶋実・茂木一孝・菊水健史
    • Organizer
      第29回日本行動神経内分泌研究会(JSBN)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Tracking of Body Parts of the Dog using DeepLabCut2018

    • Author(s)
      Satoshi Murashige, Takatomi Kubo, Rina Ouchi, Eri Nakahara, Takefumi Kikusui, Kazushi Ikeda
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Attachment behavior and emotional contagion between humans and dogs2018

    • Author(s)
      Maaya Saito, Miho Nagasawa, Takefumi Kikusui
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of dogs' attachment behaviors to humans2018

    • Author(s)
      Sakiko Tomori, Miho Nagasawa, Haruna Otsuka, Tomoko Morita, Kazutaka Mogi, Takefumi Kikusui
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Human-dog interaction by visual and auditory signals2018

    • Author(s)
      Shohei Matsushita, Miho Nagasawa, Takefumi Kikusui
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Respiration synchronizations between humans and dogs2018

    • Author(s)
      Tomoki Hashimoto, Miho Nagasawa, Takefumi Kikusui
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Social role of eye-blinking between humans and cats2018

    • Author(s)
      Hikari Koyasu, Takefumi Kikusui, Miho Nagasawa
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Social communicative ability in a mouse autism model2018

    • Author(s)
      Risa Kato, Akihiro Machida, Kensaku Nomoto, Noboru Hiroi, Kazutaka Mogi, Takefumi Kikusui
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Inhibition of corticosterone synthesis with metyrapone reduces pro-social behavior in rats2018

    • Author(s)
      Madoka Nakamura, Yuri Sugano, Kazutaka Mogi, Peggy Mason, Takefumi Kikusui
    • Organizer
      日本動物心理学会第78回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Social role of eye-blinking between humans and cats2018

    • Author(s)
      子安ひかり
    • Organizer
      ミニシンポジウム「研究対象としてのイエネコの多面性」
    • Related Report
      2018 Annual Research Report
  • [Presentation] 犬の情動をらリアルタイムに読み取り、可視化する技術の開発2018

    • Author(s)
      菊水健史
    • Organizer
      ImPACTタフ・ロボティックス・チャレンジ 公開シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 動物行動の多様性2018

    • Author(s)
      菊水健史
    • Organizer
      第65回日本実験動物学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 動物における情動伝染を支えるシグナルの同定とそのメカニズム2018

    • Author(s)
      菊水健史
    • Organizer
      新学術「共感性」領域成果報告シンポジウム「共感性学の創成」
    • Related Report
      2018 Annual Research Report
  • [Presentation] オキシトシンによる母子間の絆形成2018

    • Author(s)
      菊水健史
    • Organizer
      小児内分泌研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Reciprocal communication and endocrine response in human-dog interaction2017

    • Author(s)
      菊水健史
    • Organizer
      国際シンポジウム 異種間情報伝達から学ぶコミュニケーションの基礎
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 幼少期ストレス負荷による 情動行動の変化2016

    • Author(s)
      菊水健史
    • Organizer
      日本薬理学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 内分泌を社会から考える2015

    • Author(s)
      菊水健史
    • Organizer
      神経内分泌学会
    • Place of Presentation
      東北大学
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Oxytocin forms inter-individual relationship2015

    • Author(s)
      Takefumi Kikusui
    • Organizer
      日本神経科学
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Early weaning impaired fear extinction and decreased BDNF expression in the prefrontal cortex in adult C57BL/6 mice2015

    • Author(s)
      Kazutaka Mogi and Takefumi Kiksui
    • Organizer
      日本神経科学
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
  • [Book] 社会の起源2019

    • Author(s)
      菊水 健史、市川 眞澄
    • Total Pages
      162
    • Publisher
      共立出版
    • ISBN
      4320057961
    • Related Report
      2018 Annual Research Report
  • [Book] オオカミと野生のイヌ2018

    • Author(s)
      菊水 健史、澤井 聖一
    • Total Pages
      207
    • Publisher
      エクスナレッジ
    • ISBN
      4767825016
    • Related Report
      2018 Annual Research Report
  • [Book] 遺伝子から解き明かす性の不思議な世界2018

    • Author(s)
      菊水健史他
    • Total Pages
      544
    • Publisher
      一色出版
    • ISBN
      4909383069
    • Related Report
      2018 Annual Research Report
  • [Remarks] 麻布大学伴侶動物学研究室

    • URL

      https://sites.google.com/a/carazabu.com/car/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 伴侶動物学研究室Publications

    • URL

      https://sites.google.com/a/carazabu.com/car/publications

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-08-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi