| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
Some filamentous fungi persist under the severe environment. This study investigated fungal mechanisms that tolerate the model fungus Aspergillus nidulans to environmental stress. We identified novel genes required for normal growth tolerance to one of the stressors, nitric oxide. These genes included napA, rbgA, rcoD and snaD. They also included proC, argB, and cpcA, which are related to the fungal amino acid biosynthesis, suggesting that relationship between fungal NO-tolerance and amino acids metabolisms. Secondary metabolite production is a fungal mechanism and often induced by environmental stresses through activity of sirtuins. This study also characterized functions of the sirtuin isozymes SirE, SirC, and SirD of this fungus on the secondary metabolite production. Inhibitors of histone deacetylase activity of the sirtuin (SirA) were identified in a library of fungal culture extracts.
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