Budget Amount *help |
¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
|
Outline of Final Research Achievements |
This study using conditional mutant mice of BMAL1 showed that hippocampal circadian clock controlled by BMAL1 regulates retrieval of hippocampus-dependent memories such as contextual fear and social recognition memories. Furthermore, time-dependent regulation of these memory retrievals was also observed in wild type mice. Interestingly, BMAL1-mediated memory retrieval requires activation of Dopamine-Dopamine D1/D5 receptors-cAMP signal transduction in the hippocampus.
|