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Integrated genomics on important medicinal plants in Leguminosae

Research Project

Project/Area Number 15H02494
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Natural medicines
Research InstitutionChiba University

Principal Investigator

Saito Kazuki  千葉大学, 大学院薬学研究院, 教授 (00146705)

Co-Investigator(Kenkyū-buntansha) 山崎 真巳  千葉大学, 大学院薬学研究院, 准教授 (70222370)
ライ アミット  千葉大学, 大学院薬学研究院, 特任助教 (60760535)
鈴木 秀幸  公益財団法人かずさDNA研究所, ゲノム事業推進部, グループ長 (80276162)
Research Collaborator YOSHIMOTO naoko  
TAKAHASHI hiroki  
SAKURAI tetsuya  
MOCHIDA keiichi  
NAKABAYASHI ryo  
HIRAKAWA hideki  
KOJOMA mareshige  
SEKI hikaru  
MURANAKA toshiya  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2018: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2017: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2015: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Keywords薬用植物 / 植物二次代謝 / ゲノム / 甘草 / 薬学 / 二次代謝 / トランスクリプトーム / 遺伝子
Outline of Final Research Achievements

Licorice is a representative of the most important herbal medicines whose availability is at stake. We have obtained 379 Mbp draft genome information equivalent to 94.5% of the total genome-size constructed for Glycyrrhiza uralensis, and the genes encoding 34,445 proteins were predicted. Furthermore, genome sequences and related information were acquired in the same way for other licorice species and an important medicinal plant of the Leguminosae family. Thus, we provided a research platform for integrated genomics of medicinal plants.

Academic Significance and Societal Importance of the Research Achievements

甘草は漢方処方の7割に配合されている最も使用頻度の高い重要な生薬であるが、その供給はすべてが輸入であり、多くを中国に依存している。しかし、中国での甘草の輸出規制が始まり、その安定供給が深刻に危惧されている。本研究は、漢方処方に用いられる重要生薬の基原植物において初めてのゲノム配列決定であり、この分野の研究進展に大きく貢献した。特に、発表論文の一つは高被引用度トップ1%論文に選定され注目された。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (18 results)

All 2019 2018 2017 2016 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 8 results,  Invited: 8 results) Remarks (1 results)

  • [Journal Article] A new era in plant functional genomics2019

    • Author(s)
      Rai Amit、Yamazaki Mami、Saito Kazuki
    • Journal Title

      Current Opinion in Systems Biology

      Volume: 15 Pages: 58-67

    • DOI

      10.1016/j.coisb.2019.03.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Plant Metabolomics and Medicinal Plant Genomics2018

    • Author(s)
      Saito Kazuki
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 138 Issue: 1 Pages: 1-18

    • DOI

      10.1248/yakushi.17-00193

    • NAID

      130006300863

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2018-01-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perspective: functional genomics towards new biotechnology in medicinal plants2018

    • Author(s)
      Mami Yamazaki, Amit Rai, Naoko Yoshimoto, Kazuki Saito
    • Journal Title

      Plant Biotechnology Reports

      Volume: 12 Issue: 2 Pages: 69-75

    • DOI

      10.1007/s11816-018-0476-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated omics analysis of specialized metabolism in medicinal plants2017

    • Author(s)
      Rai Amit、Saito Kazuki、Yamazaki Mami
    • Journal Title

      The Plant Journal

      Volume: 90 Issue: 4 Pages: 764-787

    • DOI

      10.1111/tpj.13485

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysine-derived Alkaloids: Overview and Update on Biosynthesis and Medicinal Applications with Emphasis on Quinolizidine Alkaloids2017

    • Author(s)
      Bunsupa Somnuk、Yamazaki Mami、Saito Kazuki
    • Journal Title

      Mini-Reviews in Medicinal Chemistry

      Volume: 17 Issue: 12 Pages: 1002-1012

    • DOI

      10.2174/1389557516666160506151213

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Draft genome assembly and annotation of Glycyrrhiza uralensis, a medicinal legume2017

    • Author(s)
      Keiichi Mochida, Tetsuya Sakurai, Hikaru Seki, Takuhiro Yoshida, Kotaro Takahagi, Satoru Sawai, Hiroshi Uchiyama, Toshiya Muranaka, Kazuki Saito
    • Journal Title

      The Plant Journal

      Volume: 89 Issue: 2 Pages: 181-194

    • DOI

      10.1111/tpj.13385

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] アルカロイド生合成遺伝子を発現したシロイヌナズナにおける新規代謝物生産2019

    • Author(s)
      清水陽平, 佐藤大, 鈴木秀幸, 斉藤和季, 山崎真巳
    • Organizer
      第60回 日本植物生理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シロイヌナズナへのリジン脱炭酸酵素遺伝子導入による新規代謝経路誘導と化学多様性の拡張2019

    • Author(s)
      清水陽平、Amit Rai、佐藤大、鈴木秀幸、斉藤和季、山崎真巳
    • Organizer
      日本薬学会 第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Phytochemical genomics: from Arabidopsis to medicinal plants2018

    • Author(s)
      Kazuki Saito
    • Organizer
      The 3rd Conference of the International Society for Plant Molecular Farming
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phytochemical genomics for biosynthesis of specialized products in medicinal plants2018

    • Author(s)
      Kazuki Saito
    • Organizer
      Western Pacific Regional Forum for the Harmonization of Herbal Medicines 7th International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シロイヌナズナへのリジン/オルニチン脱炭酸酵素遺伝子導入によるカダベリン代謝誘導2018

    • Author(s)
      清水陽平,大川結子、佐藤大、鈴木秀幸、斉藤和季、山崎真巳
    • Organizer
      日本生薬学会 第65回年会(広島)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Discovery of novel genes and metabolites through plant genomics and metabolomics - From Arabidopsis to specialized plants2017

    • Author(s)
      Kazuki Saito
    • Organizer
      Annual Conference of American Society of Plant Biologists 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phytochemical genomics - A basis for the future research of plant natural products chemistry2017

    • Author(s)
      Kazuki Saito
    • Organizer
      The 32nd International Symposium on Natural Products
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metabolomics-based functional genomics of plant metabolism - From Arabidopsis to medicinal plants2017

    • Author(s)
      Kazuki Saito
    • Organizer
      15th Asian Symposium on Medicinal Plants, Spices, and other Natural Products (ASOMPS XV)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phytochemical Genomics: A Basis for Redesign of Plant Natural Products Biosynthesis2017

    • Author(s)
      Kazuki Saito
    • Organizer
      International Symposium on Creation of Complex Functional Molecules by Rational Redesign of Biosynthetic Machineries. The 137th Annual Congress of The Pharmaceutical Society of Japan.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phytochemical genomics - from a model plant to medicinal plants2016

    • Author(s)
      Kazuki Saito
    • Organizer
      9th Joint Natural Procucts Conference 2016
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2016-07-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Discovery of novel genes and metabolites through plant genomics and metabolomics - From Arabidopsis to specialized plants2016

    • Author(s)
      Kazuki Saito
    • Organizer
      International Symposium in Natural Products for the Future 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 千葉大学大学院薬学研究院遺伝子資源応用研究室

    • URL

      http://www.p.chiba-u.jp/lab/idenshi/index.html

    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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