| Budget Amount *help |
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2017: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2015: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Outline of Final Research Achievements |
We identified a novel subset of innate myeloid cells (CD160high CD163high cells) in the human intestinal lamina propria. This subset, which was present only in the intestine, produced high amounts of IL-10 and suppressed proliferation of effector T cells. In Crohn’s disease patients, suppressive function of effector T cell proliferation of the CD160high CD163high cell subset was impaired. In ulcerative colitis patients, the number of the subset was decreased and the suppressive function was also impaired. Thus, we showed that the unique subset of innate myeloid cells in the human intestinal lamina propria contributes to the maintenance of the intestinal homeostasis.
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