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免疫応答における好塩基球の生理的・病的役割の解明

Research Project

Project/Area Number 15H02515
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

烏山 一  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60195013)

Project Period (FY) 2015-04-01 – 2016-03-31
Project Status Discontinued (Fiscal Year 2015)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2015: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Keywords免疫 / アレルギー / 寄生虫感染 / 炎症 / 好塩基球 / プロテアーゼ
Outline of Annual Research Achievements

基盤(S)に採択されたため、基盤(A)における研究期間はH27年4月と5月の二ヶ月間のみである。この間、好塩基球のみが産生するプロテアーゼmMCP-8の生体内における役割を解明するために、リコンビナントmMCP-8蛋白を作製した。マウスの皮内に投与したところ、細胞浸潤を伴う炎症が惹起された。このことから、mMCP-8は好塩基球由来の炎症誘導エフェクター分子のひとつであると考えられる。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(1 results)
  • 2015 Annual Research Report
  • Research Products

    (6 results)

All 2015 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.2015

    • Author(s)
      Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
    • Journal Title

      Immunity

      Volume: 43 Issue: 1 Pages: 175-86

    • DOI

      10.1016/j.immuni.2015.06.021

    • NAID

      40020962854

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens2015

    • Author(s)
      LiHua Li, Takuya Ohta, Kayo Horiguchi, Yohei Kawano, Hiroshi Ohtsu, Yoshinori Yamanishi, MD., Hajime Karasuyama.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 467 Issue: 1 Pages: 70-75

    • DOI

      10.1016/j.bbrc.2015.09.120

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Basophils: A key player in immunity and inflammation2015

    • Author(s)
      Karasuyama, H.
    • Organizer
      XXIV World Allergy Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 外部ならびに内部寄生虫感染防御における好塩基球の重要性2015

    • Author(s)
      烏山 一
    • Organizer
      日本獣医学会
    • Place of Presentation
      北里大学十和田キャンパス
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 好塩基球研究の再興2015

    • Author(s)
      烏山 一
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Remarks] 免疫アレルギー学分野

    • URL

      http://immune-regulation.org

    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2017-01-06  

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