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A large-scale long-term cohort study contributing extension of healthy life expectancy based on the bone-disease cross-talk

Research Project

Project/Area Number 15H02526
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionKindai University

Principal Investigator

IKI Masayuki  近畿大学, 医学部, 教授 (50184388)

Co-Investigator(Kenkyū-buntansha) 佐藤 裕保  仁愛大学, 人間生活学部, 教授 (10337115)
藤田 裕規  近畿大学, 医学部, 講師 (10330797)
立木 隆広  近畿大学, 医学部, 助教 (10734650)
上西 一弘  女子栄養大学, 栄養学部, 教授 (40232764)
梶田 悦子  中京学院大学, 看護学部, 教授 (50135373)
文 鐘聲  畿央大学, 健康科学部, 准教授 (50460960)
甲田 勝康  近畿大学, 医学部, 准教授 (60273182)
由良 晶子  近畿大学, 医学部, 講師 (80142595)
北川 淳  北里大学, 一般教育部, 教授 (80260529)
玉置 淳子  大阪医科大学, 医学部, 教授 (90326356)
岡本 希  奈良県立医科大学, 医学部, 准教授 (70364057)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2016: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords骨折 / 骨粗鬆症 / 糖尿病 / 動脈硬化 / 骨-疾患連関 / 健康寿命 / 心血管疾患 / 骨-疾患関連 / 骨密度 / 骨疾患連関 / 骨代謝 / エネルギー代謝 / 予防医学 / 骨折予防 / 骨折リスク評価
Outline of Final Research Achievements

We have conducted 10-year follow-up survey in the FORMEN cohort study and 20-year follow-up survey in the JPOS cohort study, and identified fractures and deaths as the outcome. According to the study results obtained, we speculate that low intakes of vitamin D, milk and natto, gastrectomy, anemia, hypouricemia and diabetes mellitus may increase the risk of osteoporotic fractures which lead to development of atherosclerosis resulting in elevated risk of mortality. Prevention and management of osteoporosis and osteoporotic fractures may decrease the risk of mortality and extend the healthy life expectancy.

Academic Significance and Societal Importance of the Research Achievements

本コホートの縦断研究によって、これまで動物実験やヒトの断面研究での検討しかなかった分野で関連の時間性を証明することができた。骨-疾患連関ではオステオカルシンの作用は否定された一方、AGEやesRAGEは糖尿病による骨脆弱性の進行や動脈硬化の進展に寄与することが示唆された。以上より、骨粗鬆症を予防、管理し、骨折を防ぐことは死亡のリスクを下げ、健康寿命の延伸に寄与することが示唆された。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (20 results)

All 2020 2019 2018 2016 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (8 results) (of which Int'l Joint Research: 3 results) Remarks (5 results)

  • [Journal Article] Decreased bone mineral density and osteoporotic fractures are associated with the development of echogenic plaques in the carotid arteries over a 10-year follow-up period: The Japanese Population-based Osteoporosis (JPOS) Cohort Study2020

    • Author(s)
      Hamada Masami、Kajita Etsuko、Tamaki Junko、Kouda Katsuyasu、Sato Yuho、Tachiki Takahiro、Yura Akiko、Kamiya Kuniyasu、Nitta Akemi、Kagamimori Sadanobu、Iki Masayuki
    • Journal Title

      Maturitas

      Volume: 131 Pages: 40-47

    • DOI

      10.1016/j.maturitas.2019.10.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natto Intake is Inversely Associated with Osteoporotic Fracture Risk in Postmenopausal Japanese Women2019

    • Author(s)
      Kojima Akane、Ikehara Satoyo、Kamiya Kuniyasu、Kajita Etsuko、Sato Yuho、Kouda Katsuyasu、Tamaki Junko、Kagamimori Sadanobu、Iki Masayuki
    • Journal Title

      The Journal of Nutrition

      Volume: 150 Issue: 3 Pages: 599-605

    • DOI

      10.1093/jn/nxz292

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between hand-grip strength and site-specific risks of major osteoporotic fracture: Results from the Japanese Population-based Osteoporosis Cohort Study2019

    • Author(s)
      Kamiya Kuniyasu、Kajita Etsuko、Tachiki Takahiro、Ikehara Satoyo、Kouda Katsuyasu、Sato Yuho、Tamaki Junko、Kagamimori Sadanobu、Iki Masayuki
    • Journal Title

      Maturitas

      Volume: 130 Pages: 13-20

    • DOI

      10.1016/j.maturitas.2019.09.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased risk of osteoporotic fracture in community-dwelling elderly men 20 or more years after gastrectomy: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study2019

    • Author(s)
      Iki Masayuki、Fujita Yuki、Kouda Katsuyasu、Yura Akiko、Tachiki Takahiro、Tamaki Junko、Sato Yuho、Moon Jong-Seong、Hamada Masami、Kajita Etsuko、Okamoto Nozomi、Kurumatani Norio
    • Journal Title

      Bone

      Volume: 127 Pages: 250-259

    • DOI

      10.1016/j.bone.2019.06.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperglycemic status is associated with an elevated risk of osteoporotic fracture in community-dwelling elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) cohort study.2019

    • Author(s)
      Iki M, Fujita Y, Kouda K, Yura A, Tachiki T, Tamaki J, Sato Y, Moon JS, Hamada M, Kajita E, Okamoto N, Kurumatani N.
    • Journal Title

      Bone.

      Volume: 121 Pages: 100-106

    • DOI

      10.1016/j.bone.2019.01.005

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low bone mineral density is associated with an elevated risk of developing increased arterial stiffness: A 10-year follow-up of Japanese women from the Japanese Population-based Osteoporosis (JPOS) cohort study2019

    • Author(s)
      Jaalkhorol Myadagmaa、Fujita Yuki、Kouda Katsuyasu、Tamaki Junko、Komatsu Misa、DongMei Namiraa、Sato Yuho、Tachiki Takahiro、Yura Akiko、Kajita Etsuko、Kagamimori Sadanobu、Iki Masayuki
    • Journal Title

      Maturitas

      Volume: 119 Pages: 39-45

    • DOI

      10.1016/j.maturitas.2018.11.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Does Trabecular Bone Score (TBS) Improve the Predictive Ability of FRAX® for Major Osteoporotic Fractures According to the Japanese Population-Based Osteoporosis (JPOS) Cohort Study?2018

    • Author(s)
      J Tamaki, M Iki, Y Sato, R Winzenrieth, E Kajita, S Kagamimori
    • Journal Title

      JBMM

      Volume: - Issue: 1 Pages: 1-10

    • DOI

      10.1007/s00774-018-0910-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Gastrectomy is associated with increased risk of osteoporotic fracture in community-dwelling elderly men 20 years or more after the surgery: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study2019

    • Author(s)
      Masayuki Iki, Yuki Fujita, Katsuyasu Kouda, Akiko Yura, Takahiro Tachiki, Junko Tamaki, Yuho Sato, Jong-Seong Moon, Masami Hamada, Etsuko Kajita, Nozomi Okamoto, and Norio Kurumatani
    • Organizer
      46th European Calcified Tissue Society Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シスタチンCに基づくeGFR低値は骨粗鬆症性骨折リスク上昇と関連したが、クレアチニンに基づくeGFRは関連しなかった 藤原京スタディ男性骨粗鬆症コホート研究2019

    • Author(s)
      伊木 雅之, 藤田 裕規, 甲田 勝康, 由良 晶子, 立木 隆広, 玉置 淳子, 佐藤 裕保, 梶田 悦子, 岡本 希, 車谷 典男
    • Organizer
      日本骨粗鬆症学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨形成抑制因子スクレロスチン値と上腕-足首脈波伝播速度値増加リスクの関連 the JPOS Cohort Studyによる縦断的検討2019

    • Author(s)
      玉置 淳子, ジャルホロル ミャガダマ , ドンメイ ナミラー, 神谷 訓康, 立木 隆広, 新田 明美, 甲田 勝康, 鏡森 定信, 伊木 雅之
    • Organizer
      日本骨粗鬆症学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 牛乳の摂取頻度と骨粗鬆症性骨折発生リスクの関連 JPOSコホート研究による縦断的検討2019

    • Author(s)
      兒島 茜, 神谷 訓康, 梶田 悦子, 佐藤 裕保, 甲田 勝康, 玉置 淳子, 鏡森 定信, 伊木 雅之
    • Organizer
      日本骨粗鬆症学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 貧血と脆弱性骨折との関連 藤原京スタディ男性骨粗鬆症コホート研究による縦断的検討2019

    • Author(s)
      貫井 裕次, 玉置 淳子, 藤田 裕規, 梶田 悦子, 甲田 勝康, 由良 晶子, 立木 隆広, 神谷 訓康, 佐藤 裕保, 伊木 雅之, 岡本 希, 車谷 典男
    • Organizer
      日本公衆衛生学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 地域在住高齢男性における胃切除後の骨折リスク上昇 藤原京スタディ男性骨粗鬆症研究2019

    • Author(s)
      伊木 雅之, 藤田 裕規, 甲田 勝康, 由良 晶子, 立木 隆広, 玉置 淳子, 佐藤 裕保, 梶田 悦子, 濱田 昌実, 岡本 希, 車谷 典男
    • Organizer
      日本骨形態計測学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Higher levels of serum uric acid were associated with lower risk of vertebral fracture independently of bone density and renal function. Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study.2018

    • Author(s)
      Iki M, Fujita Y, Yura A, Kouda K, Tachiki T, Sato Y, Tamaki J, Kajita E, Moon JS, Okamoto N, Kurumatani N
    • Organizer
      World Congress on Osteoporosis 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fasting plasma glucose and glycated hemoglobin A1c levels were associated positively with bone density and inversely with trabecular bone score in Japanese elderly men. - Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study -2016

    • Author(s)
      Iki M, Fujita Y, Kouda K, Yura A, Sato Y, Mun JS, Tamaki J, Winzenrieth R, Okamoto N, Kurumanani N
    • Organizer
      World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2016)
    • Place of Presentation
      Malaga (Spain)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] JPOS研究

    • URL

      https://www.med.kindai.ac.jp/pubheal/jpos/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 藤原京スタディ男性骨粗鬆症(FORMEN)研究

    • URL

      https://www.med.kindai.ac.jp/pubheal/FORMEN/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] The JPOS Study

    • Related Report
      2018 Annual Research Report
  • [Remarks] The JPOS Study

    • Related Report
      2017 Annual Research Report
  • [Remarks] The JPOS Study

    • URL

      http://www.med.kindai.ac.jp/pubheal/jpos/index.html

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report

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Published: 2015-04-16   Modified: 2022-11-04  

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