| Project/Area Number |
15H02530
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Ishii Akira 名古屋大学, 医学系研究科, 教授 (30252175)
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| Co-Investigator(Kenkyū-buntansha) |
那須 民江 中部大学, 生命健康科学部, 教授 (10020794)
林 由美 名古屋大学, 医学系研究科(保健), 助教 (30632707)
財津 桂 名古屋大学, 医学系研究科, 准教授 (30700546)
土橋 均 名古屋大学, 医学系研究科, 招へい教員 (40596029)
妹尾 洋 愛知医科大学, 医学部, 教授 (50236113)
小川 匡之 愛知医科大学, 医学部, 講師 (50559937)
草野 麻衣子 名古屋大学, 医学系研究科, 特任助教 (60733574)
内藤 久雄 藤田保健衛生大学, 医学部, 講師 (90547556)
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| Research Collaborator |
HISATSUNE KAZUAKI 愛知県科学捜査研究所, 化学鑑定室, 警察職員
NAKAJIMA JUN'ICHI 東京都健康安全研究センター, 生薬研究室, 主任研究員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Keywords | 法中毒学 / 法医学 / 質量分析 / 危険ドラッグ / 合成カンナビノイド / 飛行時間型質量分析計 / 全自動化 / カチノン / 法中毒 / タンデム質量分析計 |
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| Outline of Final Research Achievements |
The aim of this project is to develop simple and comprehensive methods for determining novel abused drugs including synthetic cannabinoids by combining ultra-sensitive and/or highly specific mass spectrometers, and conventional mass spectrometers. We developed a simple method for determining several synthetic cannabinoids and their metabolites using a high-performance liquid chromatography-quadrupole time-of-flight mass spectrometer (LC-QTOFMS). The combination of an LC-QTOFMS and an LC-QTrap enabled the first identification of 5-fluoro-ADB (5-F-ADB) in the blood of a fatal intoxication case of 5-F-ADB and diphenidine. We then proposed possible metabolic pathways of the compounds. We are now investigating the difference of 5-F-ADB levels among organs in which the expression levels of carboxyesterase differ.
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