Exploring the mechanism of cardiac development and regeneration based on diverse cellular origins

• Project/Area Number: 15H02536
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Kurihara Hiroki 東京大学, 大学院医学系研究科(医学部), 教授 (20221947)
• Co-Investigator(Kenkyū-buntansha): 富田 幸子 ヤマザキ学園大学, 動物看護学部, 教授 (40231451)
• Co-Investigator(Renkei-kenkyūsha): WADA Yoichiro 東京大学, アイソトープ総合センター, 教授 (10322033) ; KURIHARA Yukiko 東京大学, 大学院医学系研究科, 講師 (80345040) ; UCHIJIMA Yasunobu 東京大学, 大学院医学系研究科, 助手 (90272426)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000); Fiscal Year 2017: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2016: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2015: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
• Keywords: 分子心臓学 / 発生・分化 / 循環器 / 心臓 / 血管 / 器官形成 / 細胞分化 / 再生医学

Outline of Final Research Achievements

We identified the preotic neural crest and amniogenic somatopleural mesoderm as novel origins of cardiovascular components, found phenotypic diversity within each lineage by single-cell transcriptome analysis, and revealed signals that possibly regulate their differentiation and migration. In coronary artery development, we found the involvement of coordination between cells giving rise to the coronary ostia and forming lymphatic vessels. The signaling molecules mediating their interaction are also involved in post-ischemic cardiac injury, which indicates their potential as a novel therapeutic target in myocardial infarction.

Research Products

• [Journal Article] Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system. (2017)
  • Author(s): Asai R, Haneda Y, Seya D, Arima Y, Fukuda K, Kurihara Y, Miyagawa-Tomita S, Kurihara H.
  • Journal Title: Sci Rep. Volume: 7(1)8955 Issue: 1 Pages: 1-14
  • DOI: 10.1038/s41598-017-08305-2
  • Peer Reviewed / Open Access
• [Journal Article] Integrate and Fire Model with Refractory Period for Synchronization of Two Cardiomyocytes. (2017)
  • Author(s): Hayashi T, Tokihiro T, Kurihara H, Nomura F, Yasuda K.
  • Journal Title: Journal of Theoretical Biology Volume: 437 Pages: 141-148
  • DOI: 10.1016/j.jtbi.2017.10.008
  • Peer Reviewed / Open Access
• [Journal Article] Community effect of cardiomyocytes in beating rhythms is determined by stable cells. (2017)
  • Author(s): Hayashi T, Tokihiro T, Kurihara H, Yasuda K.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 15450-15450
  • DOI: 10.1038/s41598-017-15727-5
  • Peer Reviewed / Open Access
• [Journal Article] A Mathematical Modeling of Angiogenesis (2016)
  • Author(s): 間田潤，松家敬介，由良文孝，栗原裕基，時弘哲治
  • Journal Title: Transactions of the Japan Society for Industrial and Applied Mathematics Volume: 26 Issue: 1 Pages: 105-123
  • DOI: 10.11540/jsiamt.26.1_105
  • NAID: 110010042558
  • ISSN: 2424-0982
  • Peer Reviewed / Open Access
• [Journal Article] A DISCRETE MATHEMATICAL MODEL FOR ANGIOGENESIS (2016)
  • Author(s): K. MATSUYA, F. YURA, J. Mada, H. KURIHARA, T. TOKIHIRO
  • Journal Title: SIAM J. APPL. MATH. Volume: 76 Issue: 6 Pages: 2243-2259
  • DOI: 10.1137/15m1038773
  • Peer Reviewed / Open Access
• [Journal Article] Developmental mechanisms of the tympanic membrane in mammals and non-mammalian amniotes (2016)
  • Author(s): Takechi, M., Kitazawa, T., Hirasawa, T., Hirai, T., Iseki, S., Kurihara, H., Kuratani, S.
  • Journal Title: Congenital Anomalies Volume: 56 Issue: 1 Pages: 12-17
  • DOI: 10.1111/cga.12132
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. (2016)
  • Author(s): Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A
  • Journal Title: J Clin Invest Volume: 126 Issue: 9 Pages: 3417-3432
  • DOI: 10.1172/jci85880
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Postotic and preotic cranial neural crest cells differently contribute to thyroid development. (2016)
  • Author(s): Maeda K, Asai R, Maruyama K, Kurihara Y, Nakanishi T, Kurihara H, Miyagawa-Tomita S.
  • Journal Title: Dev. Biol. Volume: 409(1) Pages: 72-83
  • Peer Reviewed / Open Access
• [Journal Article] Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids. (2015)
  • Author(s): Kitazawa T, Takechi M, Hirasawa T, Adachi N, Narboux-Neme N, Kume H, Maeda K, Hirai T, Miyagawa-Tomita S, Kurihara Y, Hitomi J, Levi G, Kuratani S, Kurihara H
  • Journal Title: Nature Communications Volume: 6 Issue: 1 Pages: 6853-6853
  • DOI: 10.1038/ncomms7853
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. (2015)
  • Author(s): Kitazawa T, Fujisawa K, Narboux-Neme N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H
  • Journal Title: Developmental Biology Volume: 15 Issue: 2 Pages: 162-174
  • DOI: 10.1016/j.ydbio.2015.04.007
  • Peer Reviewed / Open Access
• [Journal Article] Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. (2015)
  • Author(s): Gordon CT, Weaver KN, Zechi-Ceide RM, Madsen EC, Tavares AL, Oufadem M, Kurihara Y, （18名）, Kurihara H, .et al.
  • Journal Title: Am J Hum Genet. Volume: 96(4) Issue: 4 Pages: 519-531
  • DOI: 10.1016/j.ajhg.2015.01.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Simple model of pH-induced protein denaturation. (2015)
  • Author(s): Hidaka T, Shimada A, Nakata Y, Kodama H, Kurihara H, Tokihiro T, Ihara S.
  • Journal Title: Phys Rev E Stat Nonlin Soft Matter Phys Volume: Jul;92(1) Issue: 1 Pages: 012709-012709
  • DOI: 10.1103/physreve.92.012709
  • Peer Reviewed / Open Access
• [Journal Article] Postotic and preotic neural crest cells differently contribute to thyroid development. (2015)
  • Author(s): Kazuhiro Maeda, Rieko Asai, Kazuaki Maruyama, Yukiko Kurihara, Toshio Nakanishi, Hiroki Kurihara, Sachiko Miyagawa-Tomita.
  • Journal Title: Dev Biol Volume: 409 Issue: 1 Pages: 72-83
  • DOI: 10.1016/j.ydbio.2015.10.026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autonomy and non-autonomy of angiogenic cell movements revealed by experiment-driven mathematical modeling (2015)
  • Author(s): Sugihara K, Nishiyama K, Fukuhara S, Uemura A, Arima S, Kobayashi R, Kohn-Luque A, Mochizuki N, Suda T, Ogawa S, Kurihara H
  • Journal Title: Cell Rep Volume: 13 Issue: 9 Pages: 1814-1827
  • DOI: 10.1016/j.celrep.2015.10.051
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysregulated YAP1/TAZ and TGF signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice (2015)
  • Author(s): Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S.O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-ya, K., Mimori, K. and Suzuki, A.
  • Journal Title: PNAS Volume: 113 Issue: 1 Pages: 71-80
  • DOI: 10.1073/pnas.1517188113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem. (2015)
  • Author(s): Laumonnerie C, Bechara A, Vilain N, Kurihara Y, Kurihara H,Rijli FM.
  • Journal Title: Development. Volume: 142(21) Pages: 3704-3712
  • DOI: 10.1242/dev.128736
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Semaphorin3E-PlexinD1 signaling is important for coronary artery formation. (2017)
  • Author(s): Kazuaki Maruyama , Sachiko Miyagawa-Tomita, Yuichiro Arima, Kazuaki Naemura, Yasunobu Uchijima , Akiyoshi Uemura , Yutaka Yoshida , Fanny Mann , Yukiko Kurihara , Hiroki Kurihara
  • Organizer: Weinstein cardiovascular development and regeneration conference
  • Int'l Joint Research
• [Presentation] Semaphorin3E-PlexinD1-mediated Coordination of Blood and Lymphatic Vessels Development in the (2017)
  • Author(s): 丸山 和晃
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] 血管新生を特徴づける内皮細胞の運動様式の同定とその分子機構の解明 (2017)
  • Author(s): 礪波 一夫
  • Organizer: 第25回日本血管生物医学会学術集会
• [Presentation] 血管新生の素過程としての単一内皮細胞動態の解析 (2017)
  • Author(s): 礪波 一夫
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] 血管新生における内皮細胞の協調運動を担うVE－カドヘリンとアクチンファイバーの相互調節機構 (2017)
  • Author(s): 牛島 俊征
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] 単一細胞トランスクリプトーム解析によって明らかになった心臓内神経堤細胞の多様性 (2017)
  • Author(s): 岩瀬 晃康
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] Functional and expression analysis of islet1 and its paralogue in zebrafish heart development (2017)
  • Author(s): 水上 薫
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] 単一細胞遺伝子発現分析を用いた血管新生調節機構の解析 (2017)
  • Author(s): 内島 泰信
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] 心臓前駆細胞特異的Hoxa2異所性発言からみるHoxa2の遺伝子ネットワーク制御 (2017)
  • Author(s): 柳 のど香
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] 羊膜と同一起源をもつ心臓新規系譜の解析 (2017)
  • Author(s): 羽田 優花
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] Semaphorin3E-PlexinD1シグナルな冠動脈形成に重要である (2017)
  • Author(s): 丸山 和晃
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] 細胞運動特性と遺伝子転写制御の連携に基づく血管新生機構の解明 (2017)
  • Author(s): 栗原裕基
  • Organizer: 理研大阪Qbic
  • Invited
• [Presentation] 血管新生における細胞動態の実験及び数理解析 (2016)
  • Author(s): 栗原裕基
  • Organizer: 生命動態システム科学四拠点・CREST・PRESTO・QBiC 合同シンポジウム「生命動態の分子メカニズムと数理」
  • Place of Presentation: シェラトンホテル広島
  • Year and Date: 2016-03-26
  • Invited
• [Presentation] Semaphorin3E-PlexinD1シグナルは冠動脈形成に重要な役割を果たす (2016)
  • Author(s): 丸山和晃，富田－宮川幸子，有馬勇一郎，浅井理恵子，植村明嘉, 瀬谷大貴，吉田豊, Man Fanny, 栗原由紀子，栗原裕基
  • Organizer: 血管生物医学会 若手研究会
  • Place of Presentation: 東北大学加齢医学研究所 スマートエージング国際共同研究センター
  • Year and Date: 2016-03-04
• [Presentation] Semaphorin3E-PlexinD1 signaling is important for coronary artery formation. (2016)
  • Author(s): Kazuaki Maruyama , Sachiko Miyagawa-Tomita, Yuichiro Arima, Daiki Seya , Kazuaki Naemura, Yasunobu Uchijima , Akiyoshi Uemura , Yutaka Yoshida , Fanny Mann , Yukiko Kurihara , Hiroki Kurihara
  • Organizer: Weinstein cardiovascular development and regeneration conference 2016
  • Int'l Joint Research
• [Presentation] Semaphorin3E-PlexinD1は冠動脈形成に重要な役割を果たす (2016)
  • Author(s): 丸山 和晃, 富田ー宮川 幸子, 有馬 勇一郎, 瀬谷 大貴, 栗原 由紀子, 栗原 裕基
  • Organizer: 第52回小児循環器学会
• [Presentation] Semaphorin3E-PlexinD1 signaling is important for coronary artery formation.(Symposiast, oral presentation) (2016)
  • Author(s): Kazuaki Maruyama , Sachiko Miyagawa-Tomita, Yuichiro Arima, Kazuaki Naemura, Yasunobu Uchijima , Akiyoshi Uemura , Yutaka Yoshida , Fanny Mann , Hiroki Kurihara
  • Organizer: The 39th annual meeting of the molecular biology socirty of japan
• [Presentation] Semaphorin3E-PlexinD1は冠動脈形成に重要な役割を果たす (2016)
  • Author(s): 丸山 和晃, 富田ー宮川 幸子, 栗原 裕基
  • Organizer: 日本心臓血管発生研究会 「第15回日本心臓血管発生研究会」
• [Presentation] The role of Semaphorin3E-PlexinD1 signaling in coronary artery formation(Young investigator award finalist presentation, oral presentation) (2016)
  • Author(s): Kazuaki Maruyama , Sachiko Miyagawa-Tomita, Yuichiro Arima, Akiyoshi Uemura , Yutaka Yoshida , Fanny Mann , Hiroki Kurihara
  • Organizer: The 24th annual meeting of the Japanese vascular biology and medicine organization. The 14th Korea-japan joint symposium on vascular biology.
• [Presentation] Semaphorin3E-PlexinD1 signaling is important for coronary artery formation.(Young investigator award finalist presentation, oral presentation) (2016)
  • Author(s): Kazuaki Maruyama , Sachiko Miyagawa-Tomita, Yuichiro Arima, Kazuaki Naemura, Yasunobu Uchijima , Akiyoshi Uemura , Yutaka Yoshida , Fanny Mann , Hiroki Kurihara
  • Organizer: The 20th annual meeting of the society of cardiovascular andocrinology and metabolism.
• [Presentation] Early effects of retinoic acid on neural crest cells contributing to cardiac development （神経堤細胞の心発生への寄与とレチノイン酸の早期効果） (2016)
  • Author(s): 瀬谷大貴
  • Organizer: 日本心臓血管発生研究会 「第15回日本心臓血管発生研究会」
• [Presentation] マウス脳底動脈拡張症モデルの作成・解析 (2016)
  • Author(s): 苗村和明
  • Organizer: 第41回日本脳卒中学会総会
• [Presentation] 血管新生における巨視的内皮細胞動態 (2016)
  • Author(s): 田久保直子
  • Organizer: 第５４回日本生物物理学会年会
• [Presentation] Early effects of retinoic acid causing coronary artery malformation in mouse embryos （冠動脈形成異常を引き起こすレチノイン酸シグナルの早期効果） (2016)
  • Author(s): 瀬谷大貴
  • Organizer: 第39回日本分子生物学会年会
• [Presentation] Analysis of human rare disease of Endothelin A receptor mutations by mice model and the implication of prognosis (2016)
  • Author(s): Yukiko Kurihara, Taro Kitazawa, Risa Kotani, Christopher T. Gordon, Yumiko Kawamura, Sho Masuda, Tomoko Doi, Jeanne Amiel, Hiroki Kurihara
  • Organizer: 第39回日本分子生物学会年会
• [Presentation] Human Mutations in Endothelin A Receptor Provide an Insight into Structural rearrangement in GPCR (2016)
  • Author(s): Yukiko Kurihara, Tomoko Doi, Christopher T. Gordon, Jeanne Amiel, Hiroki Kurihara
  • Organizer: Gordon Research Conference
  • Int'l Joint Research
• [Presentation] ゼブラフィッシュの心臓発生におけるislet1およびそのパラログ遺伝子の解析 (2016)
  • Author(s): 水上薫
  • Organizer: 日本動物学会 関東支部 第69回大会
• [Presentation] 心溜出路に遊走する神経堤細胞の系譜とレチノイン酸の作用の検討 (2015)
  • Author(s): 瀬谷大貴、富田－宮川幸子、有馬勇一郎、淺井理恵子、丸山和晃、内島泰信、栗原由紀子、栗原裕基
  • Organizer: 第14回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル華の湯
  • Year and Date: 2015-12-19
• [Presentation] Semaphorin3E-PlexinD1シグナルは冠血管発生に重要である (2015)
  • Author(s): 丸山和晃，富田－宮川幸子，有馬勇一郎，浅井理恵子，植村明嘉, 瀬谷大貴，吉田豊, Man Fanny, 栗原由紀子，栗原裕基
  • Organizer: 第14回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル華の湯
  • Year and Date: 2015-12-19
• [Presentation] 単一細胞トラッキングを用いた血管内皮細胞動態解析 (2015)
  • Author(s): 田久保直子，苗村和明，吉田亮，徳永旭将，広瀬修，内島泰信，栗原由紀子，栗原裕基
  • Organizer: 第23回日本血管生物医学会学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-12-12
• [Presentation] Semaphorin3E-PlexinD1シグナルは冠動脈形成に重要な役割を果たす (2015)
  • Author(s): 丸山和晃，富田－宮川幸子，有馬勇一郎，浅井理恵子，植村明嘉, 瀬谷大貴，吉田豊, Man Fanny, 栗原由紀子，栗原裕基
  • Organizer: 第23回日本血管生物医学会学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-12-11
• [Presentation] マウス脳底動脈拡張症モデルの作成・解析 (2015)
  • Author(s): 苗村和明、中冨浩文、田口明糸、和田洋一郎、斉藤延人、栗原裕基
  • Organizer: 第23回日本血管生物医学回学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-12-11
• [Presentation] in vitro 血管新生のタイムラプスイメージングと細胞トラッキング (2015)
  • Author(s): 田久保直子
  • Organizer: 生命ダイナミクスの数理とその応用：理論からのさらなる深化（数学協働プログラム）
  • Place of Presentation: 東大数理研
  • Year and Date: 2015-12-10
• [Presentation] 形態形成における long noncodingRNA: Evf2の機能解析 (2015)
  • Author(s): 栗原由紀子
  • Organizer: 第38回日本分子生物学会年会(BMB2015)
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-12-02
• [Presentation] A homeotic transformation in neural crest-specific Dlx5-overexpressing mice.神経堤細胞特異的Dlx5過剰発現マウスにおける顎顔面のトランスフォーメーション (2015)
  • Author(s): Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Youichiro Wada, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara,
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-02
• [Presentation] Semaphorin3E-PlexinD1 signaling is important for coronary artery formation, (2015)
  • Author(s): 丸山和晃，富田－宮川幸子，有馬勇一郎，浅井理恵子，植村明嘉, 瀬谷大貴，吉田豊, Man Fanny, 栗原由紀子，栗原裕基
  • Organizer: 第38回日本分子生物学会年会(BMB2015)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-01
• [Presentation] からだのかたちづくりを科学する (2015)
  • Author(s): 栗原裕基
  • Organizer: 生命のダイナミクスと数学 公開講座
  • Place of Presentation: 東大数理研
  • Year and Date: 2015-11-21
  • Invited
• [Presentation] マウス脳底動脈露出手技の確立及びマウス脳底動脈拡張症モデルの作成・解析 (2015)
  • Author(s): 苗村和明、中冨浩文、宮脇哲、越智崇、伊藤明博、今井英明、栗原裕基、斉藤延人
  • Organizer: 第74回日本脳神経外科学会学術総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2015-10-15
• [Presentation] 血管新生における内皮細胞動態ライブイメージング (2015)
  • Author(s): 田久保直子，苗村和明，吉田亮，徳永旭将，広瀬修，内島泰信，栗原由紀子，栗原裕基
  • Organizer: 第53回日本生物物理学会年会
  • Place of Presentation: 金沢大学
  • Year and Date: 2015-09-14
• [Presentation] A homeotic transformation in Dlx5-overexpressing mice give a hint to form a dorsoventral axis. (2015)
  • Author(s): Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Youichiro Wada, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara,
  • Organizer: 第15回東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学武田先端知ビル
  • Year and Date: 2015-06-27
• [Presentation] Dlx5-overexpression mice show a homeotic transformation in the upper jaw into lower jaw-like structures.Dlx5過剰発現マウスにおける上顎の下顎構造へのトランスフォーメーション (2015)
  • Author(s): Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara,
  • Organizer: 第48回日本発生生物学会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2015-06-03
• [Presentation] Semaphorin3E-PlexinD1 signaling is important for coronary artery formation, (2015)
  • Author(s): 丸山和晃，富田－宮川幸子，有馬勇一郎，浅井理恵子，植村明嘉, 瀬谷大貴，吉田豊, Man Fanny, 栗原由紀子，栗原裕基
  • Organizer: 第48回日本発生生物学会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2015-06-03
• [Presentation] Semaphorin3E-PlexinD1 signalimg is importamt for coronary artery formation (2015)
  • Author(s): Kazuaki Maruyama, Sachiko Miyagawa-Tomita, Yuichiro Arima, Daiki Seya, Rieko Asai, Akiyoshi Uemura, Yutaka Yoshida, Mann Fanny, Yukiko Kurihara, Hiroki Kurihara,
  • Organizer: Weinstein 2015
  • Place of Presentation: Boston children’s hospital
  • Year and Date: 2015-04-30
  • Int'l Joint Research