The molecular mechanism of organ metabolic disease state and abnormal brain function caused by Elovl6-mediated qualitative changes of fatty acids

• Project/Area Number: 15H02541
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: University of Tsukuba
• Principal Investigator: Shimano Hitoshi 筑波大学, 医学医療系, 教授 (20251241)
• Co-Investigator(Kenkyū-buntansha): 松坂 賢 筑波大学, 医学医療系, 准教授 (70400679) ; 中川 嘉 筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80361351)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000); Fiscal Year 2017: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2016: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2015: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
• Keywords: 脂肪酸伸長酵素 / 脂肪毒性 / インスリン抵抗性 / 糖尿病 / 脳 / 生活習慣病 / 高次脳機能 / 脂質 / 脳・神経 / 脂肪酸

Outline of Final Research Achievements

Liver-specific Elovl6 KO mice showed enhanced hepatic insulin signaling when they were fed high-sucrose diet or were crossed with ob/ob mice. Through transcriptome and lipidomics analysis, we identified and characterized gene X and lipid Y as hepatic insulin signaling regulators. To define the role of Elovl6 in type 2 diabetes development, we assessed the effects of Elovl6 deletion in leptin receptor-deficient C57BL/KsJ db/db mice. The db/db-Elovl6 KO mice had a markedly increased β-cell mass with increased proliferation and decreased apoptosis, an adaptive increase in insulin, and improved glycemic control. Elovl6 is a fundamental factor linking dysregulated lipid metabolism to β-cell dysfunction, islet inflammation, and β-cell apoptosis in diabetes. Moreover, we found the crucial role of Elovl6 in neural stem cell function and found the key lipid that regulate neural stem cell function.

Research Products

• [Journal Article] Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights (2018)
  • Author(s): Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 38 Issue: 4 Pages: 744-756
  • DOI: 10.1161/atvbaha.117.310581
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood (2018)
  • Author(s): X Yuan, K Tsujimoto, K Hashimoto, K Kawahori, N Hanzawa, M Hamaguchi, T Seki, M Nawa, T Ehara, Y Kitamura, I Hatada, M Konishi, N Itoh, Y Nakagawa, H Shimano, T Takai-Igarashi, Y Kamei, Y Ogawa.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 636-636
  • DOI: 10.1038/s41467-018-03038-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes. (2018)
  • Author(s): Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
  • Journal Title: FEBS Lett. Volume: 592(3) Issue: 3 Pages: 422-433
  • DOI: 10.1002/1873-3468.12975
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant features. (2018)
  • Author(s): Owada Y, Tamura T, Tanoi T, Ozawa Y, Shimizu Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Matsukawa T, Isoda H, Ohkohchi N.
  • Journal Title: Pathol Int. Volume: 68(1) Issue: 1 Pages: 12-22
  • DOI: 10.1111/pin.12612
  • NAID: 120007134624
  • Peer Reviewed
• [Journal Article] 12. SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. (2017)
  • Author(s): Shimano H, Sato R.
  • Journal Title: Nat Rev Endocrinol. Volume: 13(12) Issue: 12 Pages: 710-730
  • DOI: 10.1038/nrendo.2017.91
  • Peer Reviewed
• [Journal Article] Elovl6 Deficiency Improves Glycemic Control in Diabetic db / db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity (2017)
  • Author(s): Zhao Hui、Matsuzaka Takashi、Nakano Yuta、Motomura Kaori、Tang Nie、Yokoo Tomotaka、Okajima Yuka、Han Song-iee、Takeuchi Yoshinori、Aita Yuichi、Iwasaki Hitoshi、Yatoh Shigeru、Suzuki Hiroaki、Sekiya Motohiro、Yahagi Naoya、Nakagawa Yoshimi、Sone Hirohito、Yamada Nobuhiro、Shimano Hitoshi
  • Journal Title: Diabetes Volume: 66 Issue: 7 Pages: 1833-1846
  • DOI: 10.2337/db16-1277
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling (2017)
  • Author(s): Muranaka H、Hayashi A、Minami K、Kitajima S、Kohno S、Nishimoto Y、Nagatani N、Suzuki M、Kulathunga L A N、Sasaki N、Okada N、Matsuzaka T、Shimano H、Tada H、Takahashi C
  • Journal Title: Oncogenesis Volume: 6 Issue: 6 Pages: e350-e350
  • DOI: 10.1038/oncsis.2017.51
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Critical role of CREBH-mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells (2017)
  • Author(s): Chida Takeshi、Ito Masahiko、Nakashima Kenji、Kanegae Yumi、Aoshima Takuya、Takabayashi Shuji、Kawata Kazuhito、Nakagawa Yoshimi、Yamamoto Masahiro、Shimano Hitoshi、Matsuura Tomokazu、Kobayashi Yoshimasa、Suda Takafumi、Suzuki Tetsuro
  • Journal Title: Hepatology Volume: 66 Issue: 5 Pages: 1430-1443
  • DOI: 10.1002/hep.29319
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction (2017)
  • Author(s): Kobayashi Masaki、Takeda Kanae、Narita Takumi、Nagai Keita、Okita Naoyuki、Sudo Yuka、Miura Yuri、Tsumoto Hiroki、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
  • Journal Title: FEBS Lett. Volume: 591 Issue: 24 Pages: 4067-4073
  • DOI: 10.1002/1873-3468.12914
  • NAID: 120007134579
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry (2017)
  • Author(s): Sawada Yoshikazu、Izumida Yoshihiko、Takeuchi Yoshinori、Aita Yuichi、Wada Nobuhiro、Li EnXu、Murayama Yuki、Piao Xianying、Shikama Akito、Masuda Yukari、Nishi-Tatsumi Makiko、Kubota Midori、Sekiya Motohiro、Matsuzaka Takashi、Nakagawa Yoshimi、Shimano Hitoshi、Yahagi Naoya
  • Journal Title: Biochem Biophys Res Commun. Volume: 493 Issue: 1 Pages: 40-45
  • DOI: 10.1016/j.bbrc.2017.09.081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering (2017)
  • Author(s): Takanashi M, Taira Y, Okazaki S, Takase S, Kimura T, Li CC, Xu PF, Noda A, Sakata I, Kumagai H, Ikeda Y, Iizuka Y, Yahagi N, Shimano H, Osuga JI, Ishibashi S, Kadowaki T, Okazaki H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 11 Pages: 1105-1116
  • DOI: 10.5551/jat.39552
  • NAID: 130006191603
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice. (2017)
  • Author(s): Takei K, Nakagawa Y, Wang Y, Han SI, Satoh A, Sekiya M, Matsuzaka T, Shimano H.
  • Journal Title: J Pharmacol Sci. Volume: 印刷中 Issue: 4 Pages: 214-222
  • DOI: 10.1016/j.jphs.2017.02.003
  • NAID: 120007128987
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes. (2017)
  • Author(s): Nishi-Tatsumi M, Yahagi N, Takeuchi Y, Toya N, Takarada A, Murayama Y, Aita Y, Sawada Y, Piao X, Oya Y, Shikama A, Masuda Y, Kubota M, Izumida Y, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Kawakami Y, Kadowaki T, Yamada N, Shimano H.
  • Journal Title: FEBS Lett Volume: 591 Issue: 7 Pages: 965-978
  • DOI: 10.1002/1873-3468.12620
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. (2017)
  • Author(s): Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK.
  • Journal Title: Cell Metab. Volume: 25(2) Issue: 2 Pages: 412-427
  • DOI: 10.1016/j.cmet.2016.11.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα. (2016)
  • Author(s): Nakagawa Y, Satoh A, Tezuka H, Han SI, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone H, Matsuzaka T, Yamada N, Shimano H.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 39182-39182
  • DOI: 10.1038/srep39182
  • NAID: 120007135285
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Kruppel-Like Factor 4 (AMPK/KLF4) Signaling. (2016)
  • Author(s): Sunaga H, Matsui H, Anjo S, Syamsunarno MR, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M.
  • Journal Title: J Am Heart Assoc. Volume: 5(12)
  • Peer Reviewed / Open Access
• [Journal Article] Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression. (2016)
  • Author(s): Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H.
  • Journal Title: Mol Metab. Volume: 5(11) Pages: 1092-1102
  • NAID: 120007129266
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. (2016)
  • Author(s): Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, Toya N, Oya Y, Shikama A, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O, Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK, and Shimano H
  • Journal Title: Cell Rep. Volume: 16 Issue: 9 Pages: 2373-2386
  • DOI: 10.1016/j.celrep.2016.07.069
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice. (2016)
  • Author(s): Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H.
  • Journal Title: PLoS One. Volume: 11(7) Issue: 7 Pages: e0159375-e0159375
  • DOI: 10.1371/journal.pone.0159375
  • NAID: 120007129433
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. (2016)
  • Author(s): Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han SI, Takeuchi Y, Isaka M, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Miyajima K, Nakae D, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H.
  • Journal Title: PLoS One. Volume: 11(6) Issue: 6 Pages: e0157580-e0157580
  • DOI: 10.1371/journal.pone.0157580
  • NAID: 120007135350
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system. (2016)
  • Author(s): Nakagawa Y, Oikawa F, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Song-iee H, Mizuno S. Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 27857-27857
  • DOI: 10.1038/srep27857
  • NAID: 120007135376
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. (2016)
  • Author(s): Ishiguro H, Kodama S, Horikawa C, Fujihara K, Hirose AS, Hirasawa R, Yachi Y, Ohara N, Shimano H, Hanyu O, Sone H.
  • Journal Title: Sports Med. Volume: 46(1):67-77. Issue: 1 Pages: 67-77
  • DOI: 10.1007/s40279-015-0379-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Meta-analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus (2016)
  • Author(s): Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K, Hanyu O, Sone H
  • Journal Title: Diabetes/metabolism research and reviews Volume: 32 Issue: 2 Pages: 178-186
  • DOI: 10.1002/dmrr.2680
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a (2015)
  • Author(s): Kuba M, Matsuzaka T, Matsumori R, Saito R, Kaga N, Taka H, Ikehata K, Okada N,
  • Journal Title: Sci Rep. Volume: 5 Issue: 1 Pages: 17604-17604
  • DOI: 10.1038/srep17604
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy. (2015)
  • Author(s): Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H
  • Journal Title: Biochem Biophys Res Commun. Volume: 466(3) Issue: 3 Pages: 536-540
  • DOI: 10.1016/j.bbrc.2015.09.065
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of human ELOVL5 enhancer regions controlled by SREBP. (2015)
  • Author(s): Shikama A, Shinozaki H, Takeuchi Y, Matsuzaka T, Aita Y, Murayama T, Sawada Y, Piao X, Toya N, Oya Y, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Yamada N, Shimano H, Yahagi N.
  • Journal Title: Biochem Biophys Res Commun. Volume: 465(4) Issue: 4 Pages: 857-63
  • DOI: 10.1016/j.bbrc.2015.08.101
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population (2015)
  • Author(s): Choi Y, Miura M, Nakata Y, Sugasawa T, Nissato S, Otsuki T, Sugawara J, Iemitsu M, Kawakami Y, Shimano H, Iijima Y, Tanaka K, Kuno S, Allu PK, Mahapatra NR, Maeda S, Takekoshi K.
  • Journal Title: Endocrine Journal Volume: 62 Issue: 9 Pages: 797-804
  • DOI: 10.1507/endocrj.EJ14-0471
  • NAID: 130005100640
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subendocardial Systolic Dysfunction in Asymptomatic Normotensive Diabetic Patients (2015)
  • Author(s): Enomoto M, Ishizu T, Seo Y, Yamamoto M, Suzuki H, Shimano H, Kawakami Y, Aonuma K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 8 Pages: 1749-1755
  • DOI: 10.1253/circj.CJ-15-0012
  • NAID: 130005089367
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes (2015)
  • Author(s): Fujihara K, Suzuki H, Sato A, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Yagyu H, Sone H, Shimano H.
  • Journal Title: Journal of diabetes research Volume: 印刷中 Pages: 507245-507245
  • DOI: 10.1155/2015/507245
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 生体膜の脂肪酸の長さの調節と生体制御～Elovl6と疾患～ (2017)
  • Author(s): 島野仁
  • Organizer: 第36回白金シンポジウム 脂質研究の最前線－生体膜の質的変化（リポクオリティー）による生体制御－
  • Place of Presentation: 北里大学薬学部コンベンションホール（東京都港区）
  • Year and Date: 2017-02-27
  • Invited
• [Presentation] A new aspect of organ lipids in various diseases, lessons from Elovl6. (2017)
  • Author(s): Shimano H, Matsuzaka T.
  • Organizer: The 19th Takeda Science Foundation Symposium on Bioscience “Chronic Inflammation～Initiation, Progression and Resolution
  • Place of Presentation: Takeda Pharmaceutical Company Limited（大阪府中央区）
  • Year and Date: 2017-01-20
  • Int'l Joint Research / Invited
• [Presentation] 脂質の量と質：臓器脂肪酸鎖長に視点をおいた糖尿病治療戦略 (2017)
  • Author(s): 島野 仁
  • Organizer: 第32回日本糖尿病合併症学会/第23回日本糖尿病眼学会総会
  • Invited
• [Presentation] 脂肪酸伸長酵素Elovl6による脂肪酸の質の制御と異所性脂肪 (2017)
  • Author(s): 松坂 賢、島野 仁
  • Organizer: 第38回日本肥満学会
  • Invited
• [Presentation] 脂質の量と質：脂肪酸鎖長に視点をおいた新たな代謝病態戦略 (2017)
  • Author(s): 島野 仁
  • Organizer: 第17回遺伝子・デリバリー研究会シンポジウム
  • Invited
• [Presentation] 生活習慣病における脂肪酸組成制御の重要性と脂肪酸伸長酵素Elovl6の役割 (2017)
  • Author(s): 松坂 賢、島野 仁
  • Organizer: 日本内分泌学会 第35回内分泌代謝学サマーセミナー
  • Invited
• [Presentation] 糖代謝と脂質代謝の統合～脂質パラメーターをエネルギー代謝から見つめなおす (2016)
  • Author(s): 島野仁
  • Organizer: 第22回日本糖尿病眼学会総会・第31回日本糖尿病合併症学会共催
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-10-08
  • Invited
• [Presentation] 脂質の量と質：臓器脂肪酸鎖長に視点をおいた臓器病態戦略 (2016)
  • Author(s): 島野仁
  • Organizer: 第17回日本内分泌学会関東甲信越支部学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2016-09-09
  • Invited
• [Presentation] 脂肪酸の量と質に視点をおいたNASH病態 (2016)
  • Author(s): 島野仁
  • Organizer: 第3回肝臓と糖尿病・代謝研究会
  • Place of Presentation: 石川県音楽堂（石川県金沢市）
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] 脂肪酸の量と質（ワークショップ） (2016)
  • Author(s): 島野仁
  • Organizer: 第19回日本病態栄養学会年次学術集会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 2016-01-10
  • Invited
• [Presentation] 栄養飢餓により活性化する転写因子とCREB3L3は肥満及び糖代謝を改善する (2015)
  • Author(s): 佐藤 葵、中川 嘉、松坂 賢、島野 仁
  • Organizer: 第27回分子糖尿病学シンポジウム
  • Place of Presentation: 丸ビルホール（東京）
  • Year and Date: 2015-12-05
• [Presentation] 多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明 (2015)
  • Author(s): 升田 紫、矢作直也、武内謙憲、和田亘弘、李 恩旭、沢田義一、朴賢英、曾田雄一、戸谷直樹、志鎌明人、西真紀子、久保田みどり、泉田欣彦、飯塚陽子、位高啓史、片岡一則、山田信博、島野 仁、門脇 孝
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-10-02
• [Presentation] 脂肪酸伸長酵素Elovl6の欠損はdb/dbマウスの2型糖尿病の発症・進展を抑制する (2015)
  • Author(s): 趙会、松坂 賢、中野雄太、Nie Tang、鈴木真璃衣、武内謙憲、岩崎 仁、小林和人、矢藤 繁、鈴木浩明、矢作直也、中川 嘉、山田信博、島野 仁
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-10-02
• [Presentation] トン食摂食時のエネルギー代謝に関わる新たな遺伝子発現調節機構 (2015)
  • Author(s): 中川 嘉、佐藤 葵、松坂 賢、山田信博、島野 仁
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-10-02
• [Presentation] 脂質の量と質の管理に視点を置いた動脈硬化予防戦略（教育講演） (2015)
  • Author(s): 島野仁
  • Organizer: 第16回日本内分泌学会関東甲信越支部学術集会
  • Place of Presentation: 幕張メッセ国際会議場（千葉）
  • Year and Date: 2015-09-25
  • Invited
• [Presentation] がん抑制遺伝子RBとSREBP1の発がん制御における協調的作用 (2015)
  • Author(s): 村中勇人、多田秀明、林 昭夫、南 圭一、丹下正一朗、北嶋俊輔、鈴木健之、松坂 賢、島野 仁、高橋智聡
  • Organizer: 第57回日本脂質生化学会
  • Place of Presentation: 一橋大学千代田キャンパス（東京）
  • Year and Date: 2015-05-29
• [Presentation] 新たな脂肪酸の質に関する研究から見えてくる世界と向かうべき世界（シンポジウム） (2015)
  • Author(s): 島野仁
  • Organizer: 第57回日本脂質生化学会
  • Place of Presentation: 一橋大学千代田キャンパス（東京）
  • Year and Date: 2015-05-29
  • Invited
• [Presentation] Leptin遺伝子発現調節機構のin vivo Ad-luc解析 (2015)
  • Author(s): 戸谷直樹、矢作直也、武内謙憲、西 真貴子、沢田義一、朴 賢英、曾田雄一、大屋友華里、志鎌明人、松坂賢、中川 嘉、升田 紫、久保田みどり、泉田欣彦、門脇 孝、山田信博、島野 仁
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関（山口）
  • Year and Date: 2015-05-23
• [Presentation] 脂肪組織におけるin vivo Ad-luc法によるfatty acid synthaseのプロモーター解析 (2015)
  • Author(s): 西 真貴子、矢作直也、武内謙憲、志鎌明人、戸谷直樹、大屋友華里、朴 賢英、曾田雄一、沢田義一、松坂 賢、中川 嘉、升田 紫、泉田欣彦、飯塚陽子、山田信博、門脇 孝、島野 仁
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関（山口）
  • Year and Date: 2015-05-23
• [Presentation] Creb313の動脈硬化形成における役割 (2015)
  • Author(s): 柳下友花、中川嘉、奥田佳菜子、八木豊美、佐藤葵、及川総香、松坂賢、岩崎仁、小林和人、矢作直也、矢藤繁、鈴木浩明、山田信博、島野 仁
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関（山口）
  • Year and Date: 2015-05-23
• [Presentation] 脂質パラメーターをエネルギー代謝からみつめなおす（シンポジウム 脂質代謝研究の最前線） (2015)
  • Author(s): 島野仁
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関市民会館（山口）
  • Year and Date: 2015-05-23
  • Invited
• [Presentation] 脂肪酸伸長酵素Elovl6の骨・軟骨細胞における役割の検討 (2015)
  • Author(s): 菊池愛美、嶋田昌子、松坂賢、石井清明、中川嘉、島野 仁
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 海峡メッセ下関（山口）
  • Year and Date: 2015-05-22
• [Presentation] 脂質の質に視点をおいた動脈硬化治療戦略～多価不飽和脂肪酸の最近の知見～（ランチョンセミナー） (2015)
  • Author(s): 島野仁
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京第一ホテル下関（山口）
  • Year and Date: 2015-05-21
  • Invited
• [Presentation] 脂肪酸伸長酵素Elovl6の欠損はdb/dbマウスの糖尿病の発症・進展を抑制する (2015)
  • Author(s): 松坂賢、中野雄太、趙会、唐寧、鈴木真璃衣、大野博、中川嘉、矢作直也、山田信博、島野 仁
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ（東京）
  • Year and Date: 2015-04-23
• [Presentation] 脳における脂肪酸伸長酵素Elovl6の役割 (2015)
  • Author(s): 大野博、松坂賢、吉田恵里子、伏見友希、所司慶太、中川嘉、矢作直也、山田信博、島野 仁
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ（東京）
  • Year and Date: 2015-04-23
• [Presentation] 転写因子Creb313の動脈硬化進展に及ぼす影響 (2015)
  • Author(s): 柳下友花、中川 嘉、佐藤 葵、大崎芳典、松坂 賢、山田信博、島野 仁
  • Organizer: 第52回日本臨床分子医学会学術集会
  • Place of Presentation: みやこめっせ（京都）
  • Year and Date: 2015-04-10
• [Presentation] 転写因子CREB3L3による絶食時エネルギー代謝調節機構 (2015)
  • Author(s): 中川 嘉、佐藤 葵、大崎芳典、松坂 賢、山田信博、島野 仁
  • Organizer: 第52回日本臨床分子医学会学術集会
  • Place of Presentation: みやこめっせ（京都）
  • Year and Date: 2015-04-10
• [Presentation] 肝臓における栄養パラメーターをエネルギー代謝につなげるのはエイジェネティクスか？（スポンサード・シンポジウム） (2015)
  • Author(s): 島野仁
  • Organizer: 第52回日本臨床分子医学会学術集会
  • Place of Presentation: みやこめっせ（京都）
  • Year and Date: 2015-04-10
  • Invited
• [Remarks] 筑波大学 内分泌代謝・糖尿病内科
  • URL: http://www.u-tsukuba-endocrinology.jp/