| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2017: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2016: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2015: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
|
|---|
| Outline of Final Research Achievements |
Cartilage plays important roles in joint motion and bone growth. In this project, we created conditional knockout mice and found that SIK3 regulates properties of articular cartilage and can be a target molecule for osteoarthritis. We showed that a SIK3 inhibitor rescues the mice with the osteoarthritis model and can be a lead molecule for drug. In a separate experiment, we found a molecule that sustains chondrocytic properties of chondrocytes. This compound inhibited degradation of Sox9 which is important for maintenance of chondrocytic phenotype.
|
