Investigation of the role myeloid-derived suppressor cells (MDSC) in the maternal-fetal tolerance and pregnancy-complicated female cancer progression.
| Project/Area Number |
15H02564
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
馬淵 誠士 大阪大学, 医学系研究科, 助教 (00452441)
遠藤 誠之 大阪大学, 医学系研究科, 講師 (30644794)
熊澤 惠一 大阪大学, 医学系研究科, 助教 (90444546)
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| Research Collaborator |
Matsumoto Yuri
Takahashi Ryoko
Sasano Tomoyuki
Kuroda Hiromasa
Kozasa Katsumi
Yokoi Eriko
Komura Naoko
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2017: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2016: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2015: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
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| Keywords | MDSC / エストロゲン / 妊娠 / 子宮頸癌 / 流産 / 造血幹細胞 / MDSC制御 / 婦人科癌 / 妊娠高血圧症候群 / 新規治療 |
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| Outline of Final Research Achievements |
We have investigated the impact of estradiol (E2) in the induction of MDSC as well as the roles of E2-induced MDSC in maternal-fetal tolerance or cervical cancer progression during pregnancy. We have found that E2 enhanced the proliferation of bone marrow (BM) cells, and stimulated the differentiation of BM cells into MDSC. We also found that increased E2 level during pregnancy is involved in the maternal-fetal tolerance as well as cervical cancer progression, which read to the enhanced progression of cervical/breast cancers during pregnancy. Finally we identified a novel agent PM01183, which exhibits strong inhibitory effects on MDSCs. We are conducting clinical researches to verify these preclinical findings in human.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer.2015
Author(s)
Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E, Kimura T.
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Journal Title
Scientific Reports
Volume: 15;5
Issue: 1
Pages: 18217-18217
DOI
Related Report
Peer Reviewed / Open Access
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