Generation of self-induced retinal ganglion cells with functioning axons from pluripotent stem cells.

• Project/Area Number: 15H02566
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: National Center for Child Health and Development
• Principal Investigator: AZUMA Noriyuki 国立研究開発法人国立成育医療研究センター, 感覚器・形態外科部, 医長 (10159395)
• Co-Investigator(Kenkyū-buntansha): 田中 卓 国立研究開発法人国立成育医療研究センター, 視覚科学研究室, 研究員 (20443400) ; 渡辺 修一 埼玉医科大学, 医学部, 教授 (60138120) ; 田丸 文信 埼玉医科大学, 医学部, 助教 (70337541)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000); Fiscal Year 2017: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2016: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000); Fiscal Year 2015: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
• Keywords: 網膜神経節細胞 / 軸索 / iPS細胞 / ES細胞 / 軸索流 / 電気生理学的反応 / 眼科学 / 再生医学

Outline of Final Research Achievements

We generated functional retinal ganglion cells (RGCs) from human or murine induced pluripotent cells (iPSCs) and ES cells (ESCs). The present study aims to investigate usefulness of the RGCs for reproducing medicine and drug development.
We established a procedure to assess the effects of neurotrophic and chemorepellent factors. The effects of direct and local administration of each agent on axonal projection were well evaluated. Locally sustained agents changed axon pathfinding.
We transplanted RGCs generated form murine or human ESCs and iPSCs into the vitreous cavity of mice. The donor RGCs engrafted in the recipient retina, and elongated axons into the optic nerve.

Research Products

• [Journal Article] Surgical treatments for fibrous tissue extending to the posterior retina in eyes with familial exudative vitreoretinopathy. (2018)
  • Author(s): Takahashi M, Yokoi T, Katagigi S, Yoshida-Uemura T, Nishina, S, Azuma N
  • Journal Title: Jpn J Ophthalmol Volume: 62 Issue: 1 Pages: 63-67
  • DOI: 10.1007/s10384-017-0547-4
  • NAID: 210000165825
  • Peer Reviewed
• [Journal Article] Retinal structure and function in eyes with optic nerve hypoplasia. (2017)
  • Author(s): Katagiri S, Nishina S, Yokoi T, Mikami M, Nakayama Y, Tanaka M, Azuma N.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 42480-42480
  • DOI: 10.1038/srep42480
  • Peer Reviewed / Open Access
• [Journal Article] Atypical intravitreal growth of retinoblastoma with a multi-branching configuration (2017)
  • Author(s): Nishina Sachiko、Katagiri Satoshi、Nakazawa Atsuko、Kiyotani Chikako、Yokoi Tadashi、Azuma Noriyuki
  • Journal Title: Am J Ophthalmol Case Rep Volume: 7 Pages: 4-8
  • DOI: 10.1016/j.ajoc.2017.04.003
  • Peer Reviewed / Open Access
• [Journal Article] Different foveal schisis patterns in each retinal layer in eyes with hereditary juvenile retinoschisis evaluated by en-face optical coherence tomography. (2017)
  • Author(s): Yoshida-Uemura T, Katagiri S, Yokoi T, Nishina S, Azuma N.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 255（4） Issue: 4 Pages: 719-723
  • DOI: 10.1007/s00417-016-3552-2
  • Peer Reviewed / Open Access
• [Journal Article] Anteroposterior Patterning of Gene Expression in the Human Infant Sclera: Chondrogenic Potential and Wnt Signaling. (2017)
  • Author(s): Seko Y, Azuma N, Yokoi T, Kami D, Ishii R, Nishina S, Toyoda M, Shimokawa H, Umezawa A.
  • Journal Title: Curr Eye Res. Volume: 42 Pages: 145-154
  • Peer Reviewed
• [Journal Article] Long-term surgical outcome of conventional trabeculotomy for childhood glaucoma. (2017)
  • Author(s): Ozawa H, Yamane M, Inoue E, Yoshida-Uemura T, Katagiri S, Yokoi T, Nishina S, Azuma N.
  • Journal Title: Jpn J Ophthalmol Volume: 印刷中 Issue: 3 Pages: 237-244
  • DOI: 10.1007/s10384-017-0506-0
  • Peer Reviewed / Open Access
• [Journal Article] ATYPICAL FORM OF RETINOPATHY OF PREMATURITY WITH SEVERE FIBROVASCULAR PROLIFERATION IN THE OPTIC DISC REGION (2017)
  • Author(s): Yokoi T, Katagiri S, Hiraoka M, Nakayama Y, Hosono K, Hotta Y, Nishina S, Azuma N
  • Journal Title: RETINA Volume: 印刷中 Issue: 8 Pages: 1-1
  • DOI: 10.1097/iae.0000000000001779
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of neuroactive agents on axonal growth and pathfinding of retinal ganglion cells generated from human stem cells (2017)
  • Author(s): Yokoi Tadashi、Tanaka Taku、Matsuzaka Emiko、Tamalu Fuminobu、Watanabe Shu-Ichi、Nishina Sachiko、Azuma Noriyuki
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 16757-16757
  • DOI: 10.1038/s41598-017-16727-1
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of Retinal Breaks and Surgical Outcomes in Rhegmatogenous Retinal Detachment in Familial Exudative Vitreoretinopathy (2017)
  • Author(s): Katagiri Satoshi、Yokoi Tadashi、Yoshida-Uemura Tomoyo、Nishina Sachiko、Azuma Noriyuki
  • Journal Title: Ophthalmology Retina Volume: 5 Issue: 7 Pages: 76-80
  • DOI: 10.1016/j.oret.2017.11.003
  • Peer Reviewed / Open Access
• [Journal Article] A. Anteroposterior Patterning of Gene Expression in the Human Infant Sclera: Chondrogenic Potential and Wnt Signaling. (2017)
  • Author(s): Seko Y, Azuma N, Yokoi T, Kami D, Ishii R, Nishina S, Toyoda M, Shimokawa H, Umezawa
  • Journal Title: Curr Eye Res Volume: 42（1） Issue: 1 Pages: 145-154
  • DOI: 10.3109/02713683.2016.1143015
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features of a toddler with bilateral bullous retinoschisis with a novel RS1 mutation. (2017)
  • Author(s): Katagiri S, Tanaka S, Yokoi T, Hayashi T, Matsuzaka E, Ueda K, Yoshida-Uemura T, Arakawa A, Nishina S, Kadonosono K, Azuma N.
  • Journal Title: American Journal of Ophthalmology Case Reports Volume: 5 Pages: 76-80
  • DOI: 10.1016/j.ajoc.2016.12.009
  • Peer Reviewed / Open Access
• [Journal Article] Genotype-phenotype correlation of the PAX6 gene mutations in aniridia (2016)
  • Author(s): Yokoi T, Nishina S, Fukami M, Ogata T, Hosono K, Hotta Y, Azuma N.
  • Journal Title: Human Genome Variation Volume: 3 Issue: 1 Pages: 15052-15052
  • DOI: 10.1038/hgv.2015.52
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] he role of vitreoretinal traction in the pathogenesis of maculopathy associated with optic disc pits. (2016)
  • Author(s): Yokoi T, Nakayama Y, Nishina S, Azuma N.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 254 Issue: 9 Pages: 1859-1860
  • DOI: 10.1007/s00417-016-3380-4
  • Peer Reviewed / Open Access
• [Journal Article] Generation of retinal ganglion cells with functional axons from mouse embryonic stem cells and induced pluripotent stem cells. (2016)
  • Author(s): Tanaka T, Yokoi T, Tamalu F, Watanabe S, Nishina S, Azuma N.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 57 Issue: 7 Pages: 3348-3359
  • DOI: 10.1167/iovs.16-19166
  • Peer Reviewed / Open Access
• [Journal Article] Successful scleral buckling of late-onset visual decrease in eye with retinal folds. (2016)
  • Author(s): Nakayama Y, Katagiri S, Yokoi T, Ui M, Nishina S, Azuma N
  • Journal Title: Doc Ophthalmol. Volume: 133 Issue: 2 Pages: 145-149
  • DOI: 10.1007/s10633-016-9559-5
  • Peer Reviewed / Open Access
• [Journal Article] Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia. (2016)
  • Author(s): Katagiri S, Yokoi T, Mikami M, Nishina S, Azuma N.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 254 Issue: 11 Pages: 2197-2201
  • DOI: 10.1007/s00417-016-3385-z
  • Peer Reviewed / Open Access
• [Journal Article] Electroretinographic effects of retinal dragging and retinal folds in eyes with familial exudative vitreoretinopathy. (2016)
  • Author(s): Yaguchi Y, Katagiri S, Fukushima Y, Yokoi T, Nishina S, Kondo M, Azuma N.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 30523-30523
  • DOI: 10.1038/srep30523
  • Peer Reviewed / Open Access
• [Journal Article] The mevalonate pathway regulates primitive streak formation via protein farnesylation (2016)
  • Author(s): Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Alois RW, Elling U, Penninger JM, Nishina S, Azuma N, Nishina H
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 37697-37697
  • DOI: 10.1038/srep37697
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure and morphology of radial retinal folds with familial exudative vitreoretinopathy. (2016)
  • Author(s): Katagiri S, Yokoi T, Nishina S, Azuma N.
  • Journal Title: Ophthalmology Volume: 123(3) Issue: 3 Pages: 666-8
  • DOI: 10.1016/j.ophtha.2015.09.010
  • Peer Reviewed / Open Access
• [Journal Article] Abnormal traction of the vitreous detected by swept-source optical coherence tomography is related to the maculopathy associated with optic disc pits. (2016)
  • Author(s): Yokoi T, Nakayama Y, Nishina S, Azuma N.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: in press Issue: 4 Pages: 675-682
  • DOI: 10.1007/s00417-015-3114-z
  • Peer Reviewed / Open Access
• [Journal Article] Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells (2015)
  • Author(s): Taku Tanaka, Tadashi Yokoi, Fuminobu Tamalu, Shu-Ichi Watanabe, Sachiko Nishina and Noriyuki Azuma
  • Journal Title: Scientific Reports Volume: 10(5) Issue: 1 Pages: 8344-8344
  • DOI: 10.1038/srep08344
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of congenital and developmental cataract undergoing surgical treatment (2015)
  • Author(s): Nagamoto T, Oshika T, Fujikado T, Ishibashi T, Sato M, Kondo M, Kurosaka D, Azuma N.
  • Journal Title: Jpn J Ophthalmol Volume: 59 Issue: 3 Pages: 148-56
  • DOI: 10.1007/s10384-015-0370-8
  • Peer Reviewed / Open Access
• [Journal Article] A survey of the surgical treatment of congenital and developmental cataracts in Japan (2015)
  • Author(s): Nagamoto T, Oshika T, Fujikado T, Ishibashi T, Sato M, Kondo M, Kurosaka D, Azuma N
  • Journal Title: Jpn J Ophthalmol Volume: 59 Issue: 4 Pages: 203-8
  • DOI: 10.1007/s10384-015-0385-1
  • Peer Reviewed / Open Access
• [Journal Article] 先天眼疾患における両眼視機能. (2015)
  • Author(s): 八木橋めぐみ, 仁科幸子, 萬束恭子, 鹿田千尋, 新保由紀子, 赤池祥子, 越後貫滋子, 上村朋世, 横井 匡, 東 範行
  • Journal Title: 眼臨紀 Volume: 8 (8) Pages: 564-570
  • Peer Reviewed
• [Journal Article] 特集 小児眼科診療のコツと注意点. (2015)
  • Author(s): 東 範行
  • Journal Title: OCULISTA Volume: 7 Pages: 1-77
  • Peer Reviewed
• [Journal Article] 特集 視覚障害の早期発見と治療. (2015)
  • Author(s): 東 範行・寺崎浩子
  • Journal Title: 日本医師会雑誌 Volume: 14 Pages: 1765-1835
  • Peer Reviewed
• [Journal Article] 小児と成人の視力を脅かす疾患と治療の展望. (2015)
  • Author(s): 寺崎浩子・川崎 良・石橋達朗・東 範行
  • Journal Title: 日本医師会雑誌 Volume: 14 Pages: 1765-1765
  • Peer Reviewed
• [Journal Article] 視力の確保は早期発見と的確な治療から. (2015)
  • Author(s): 東 範行
  • Journal Title: 日本医師会雑誌 Volume: 14 Pages: 1765-1765
  • Peer Reviewed
• [Journal Article] 単細胞生物の眼の構造は別々に起こった細胞内共生によって獲得された. (2015)
  • Author(s): 東 範行
  • Journal Title: 日本の眼科 Volume: 86 Pages: 1578-1579
  • Peer Reviewed
• [Presentation] Leber 先天盲の日本人患者に対する次世代シークエンサーを用いた遺伝子診断． (2017)
  • Author(s): 細野克博、仁科幸子、倉田健太郎、宮道大督、横井匡、簑島伸生、深見真紀、佐藤美保、近藤寛之、堀 田喜裕、東範行
  • Organizer: 第121 回日本眼科学会総会（東京）
• [Presentation] CRB1遺伝子変異によるレーバー先天盲2症例の臨床像． (2017)
  • Author(s): 仁科幸子、細野克博、横井匡、倉田健太郎、宮道大督、吉田朋世、深見真紀、簑島伸生、佐藤美保、堀 田喜裕、東範行
  • Organizer: 第42 回日本小児眼科学会総会（金沢）
• [Presentation] Information and Communication Technology 機器の使用が契機と思われた小児斜視症例． (2017)
  • Author(s): 吉田朋世、仁科幸子、越後貫滋子、赤池祥子、萬束恭子、松岡真未、横井匡、東範行
  • Organizer: 第 73回日本弱視斜視学会総会（金沢）
• [Presentation] 虹彩若年性黄色肉芽腫４例の臨床像と治療経過 (2017)
  • Author(s): 羅秀玉、仁科幸子、吉田朋世、木村由依、塩田曜子、松本公一、入江理恵、吉岡孝子、田中慎、横井匡、 東範行
  • Organizer: 第71回日本臨床眼科学会（東京）
• [Presentation] 重症未熟児網膜症における抗VEGF 薬治療後の重篤な再燃 (2017)
  • Author(s): 田中慎、横井匡、片桐聡、吉田朋世、仁科幸子、東範行
  • Organizer: 第 56回日本網膜硝子体学会（東京）
• [Presentation] 次世代シークエンサーの登場により遺伝性網膜変性の変異解析は大きく進歩した (2017)
  • Author(s): 細野克博、蓑島伸生、堀田喜裕
  • Organizer: 第121回日本眼科学会（東京）
• [Presentation] Changes in Macular Structure and Retinal Function in Patients with Leber Congenital Amaurosis with RPGRIP1 Mutations. （Poster） (2017)
  • Author(s): Daisuke Miyamichi, Sachiko Nishina, Katsuhiro Hosono, Tadashi Yokoi, Kentaro Kurata, Miho Sato, Shinsei Minoshima, Maki Fukami, Yoshihiro Hotta, Noriyuki Azuma
  • Organizer: ARVO 2017（Baltimore Convention Center）
  • Int'l Joint Research
• [Presentation] Swept-Source OCT Images of Morning Glory Disc Anomaly and Allied Diseases. (2016)
  • Author(s): Yoshida T, Katagiri S, Yokoi T, Nishina S, Azuma N
  • Organizer: 第55回日本網膜硝子体学会
  • Place of Presentation: ベルサール渋谷ガーデン（東京）
  • Year and Date: 2016-12-04
• [Presentation] RPGRIP1遺伝子異常によるLeber先天盲の１家系３症例の臨床像 (2016)
  • Author(s): 宮道大督、仁科幸子、細野克博、横井匡、倉田健太郎、彦谷明子、簑島伸生、佐藤美保、深見真紀、堀田喜裕、東範行
  • Organizer: 第55回日本網膜硝子体学会
  • Place of Presentation: ベルサール渋谷ガーデン（東京）
  • Year and Date: 2016-12-04
• [Presentation] 網脈絡膜コロボーマのSwept-Source光干渉断層計像 (2016)
  • Author(s): 富田匡彦、横井匡、吉田朋世、高橋真理、片桐聡、仁科幸子、東範行
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 京都国際会議場(京都）
  • Year and Date: 2016-11-03
• [Presentation] 家族性滲出性硝子体網膜症の黄斑上膜に硝子体手術を行った４例 (2016)
  • Author(s): 高橋真理、富田匡彦、吉田朋世、片桐聡、横井匡、仁科幸子、東範行
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 京都国際会議場(京都）
  • Year and Date: 2016-11-03
• [Presentation] 斜視を伴う小児に対するSpot Vision Screenerの使用経験 (2016)
  • Author(s): 萬束恭子、松岡真未、新保由紀子、赤池祥子、越後貫滋子、片桐聡、吉田朋世、横井匡、仁科幸子、東範行
  • Organizer: 第57回日本視能矯正学会
  • Place of Presentation: 大阪国際会議場(大阪）
  • Year and Date: 2016-10-15
• [Presentation] iPS細胞・ES細胞からの視神経細胞の誕生と臨床応用 (2016)
  • Author(s): 東範行
  • Organizer: 第５７回日本視能矯正学会
  • Place of Presentation: 大阪国際会議場(大阪）
  • Year and Date: 2016-10-15
  • Invited
• [Presentation] 乳児内斜視早期手術後の両眼視機能． (2016)
  • Author(s): 吉田朋世、仁科幸子、横井匡、鹿田千尋、萬束恭子、赤池祥子、越後貫滋子、東範行
  • Organizer: 第72回日本弱視斜視学会総会・第41回日本小児眼科学会総会合同学会
  • Place of Presentation: パシフィコ横浜(横浜）
  • Year and Date: 2016-06-24
• [Presentation] 次世代シークエンサーを用いたレーバー先天盲の１家系３症例の遺伝子変異解析 (2016)
  • Author(s): 細野克博、仁科幸子、宮道大督、横井匡、彦谷明子、佐藤美保、簑島伸生、深見真紀、東範行、堀田喜裕
  • Organizer: 第72回日本弱視斜視学会総会・第41回日本小児眼科学会総会合同学会
  • Place of Presentation: パシフィコ横浜(横浜）
  • Year and Date: 2016-06-24
• [Presentation] Roles of Genes in Phenotypic Diversity and Interocular Asymmetry in Patients with Familial Exudative Vitreoretinopathy. (2016)
  • Author(s): Kondo H, Uchio E, Hayashi T, Nishina S, Azuma N, Kusaka S.
  • Organizer: 2016 Annual Meeting, Association for Research in Vision and Ophthalmology
  • Place of Presentation: Seattle, U.S.A
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] 小児眼底疾患の構造と機能の検査による病態の理解 (2016)
  • Author(s): 東範行
  • Organizer: 第１２０回日本眼科学会総会
  • Place of Presentation: 仙台国際センター(宮城）
  • Year and Date: 2016-04-07
  • Invited
• [Presentation] Distinguished papaers symposium 1: Detailed structure and morphology from retinal dragging to radial retinal folds associated with familial exudative vitreoretinopathy. (2015)
  • Author(s): Katagiri S, Yokoi T, Nishina S, Azuma N.
  • Organizer: 第54回日本網膜硝子体学会
  • Place of Presentation: 東京国際フォーラム（東京・千代田区）
  • Year and Date: 2015-12-04
• [Presentation] iPS細胞による視神経の研究. (2015)
  • Author(s): 東 範行
  • Organizer: 第36回西中国眼疾患フォーラム
  • Place of Presentation: ANAクラウンプラザホテル宇部（ 山口・宇部市）
  • Year and Date: 2015-11-26
  • Invited
• [Presentation] 小児眼疾患の診かた・考え方. (2015)
  • Author(s): 東 範行
  • Organizer: 東京都眼科医会卒後研修会
  • Place of Presentation: 東京都眼科医会（東京・新宿区）
  • Year and Date: 2015-11-07
• [Presentation] 小児眼科の最近の進歩 (2015)
  • Author(s): 東 範行
  • Organizer: 第9回Midland Seninar of Ophthalmology
  • Place of Presentation: 名古屋マリオットアソシアホテル（愛知・名古屋市）
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] iPS細胞とES細胞からの網膜神経節細胞の作製. (2015)
  • Author(s): 東 範行
  • Organizer: 第8回Retina Research Meeting.
  • Place of Presentation: JRタワーホール＆カンファレンス（東京・千代田区）
  • Year and Date: 2015-10-31
• [Presentation] シンポジウム 眼科臨床の最先端-失明者ゼロを目指して. 未熟児網膜症. (2015)
  • Author(s): 東 範行
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋国際会議場（愛知・名古屋市）
  • Year and Date: 2015-10-22
• [Presentation] 両眼の収縮性乳頭周囲ぶどう腫の１例 (2015)
  • Author(s): 上村朋世、横井匡、仁科幸子、東 範行
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋国際会議場（愛知・名古屋市）
  • Year and Date: 2015-10-22
• [Presentation] 小児の発達緑内障の治療成績に関する検討． (2015)
  • Author(s): 小澤紘子、山根みお、上村朋世、八木橋めぐみ、片桐聡、横井匡、中山百合、仁科幸子、東 範行
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋国際会議場（愛知・名古屋市）
  • Year and Date: 2015-10-22
• [Presentation] 新しい視神経疾患の治療の展望―iPS細胞を用いた再生医療と創薬― (2015)
  • Author(s): 東 範行
  • Organizer: 第16回神奈川県眼科学術講演会
  • Place of Presentation: ホテルキャメロットジャパン（神奈川・横浜市）
  • Year and Date: 2015-09-26
  • Invited
• [Presentation] セミナー 創薬を目指した眼科研究. ヒトiPS細胞を用いた視神経疾患に対する創薬の研究. (2015)
  • Author(s): 東 範行
  • Organizer: 第35回日本眼薬理学会モーニングセミナー
  • Place of Presentation: ソラシティホール（東京・千代田区）
  • Year and Date: 2015-09-06
  • Invited
• [Presentation] iPS細胞を用いた視神経の研究. (2015)
  • Author(s): 東 範行
  • Organizer: 愛知県眼科医会第3回学術研修会
  • Place of Presentation: 愛知県医師会館（愛知・名古屋市）
  • Year and Date: 2015-08-29
• [Presentation] iPS細胞とES細胞からの網膜神経節細胞の作製. (2015)
  • Author(s): 東 範行
  • Organizer: 第17回Japan Macula Club.
  • Place of Presentation: 蒲郡クラシックホテル（愛知・蒲郡市）
  • Year and Date: 2015-08-22
• [Presentation] 眼の発生と遺伝. (2015)
  • Author(s): 東 範行
  • Organizer: 平成27年夏 合同症例検討会
  • Place of Presentation: 順天堂大学（東京・文京区）
  • Year and Date: 2015-08-01
  • Invited
• [Presentation] 先天眼疾患における黄斑異常と両眼視機能． (2015)
  • Author(s): 仁科幸子、八木橋めぐみ、萬束恭子、鹿田千尋、赤池祥子、越後貫滋子、上村朋世、横井匡、東 範行
  • Organizer: 第71回日本弱視斜視学会総会・第40回日本小児眼科学会総会合同学会
  • Place of Presentation: ポートピアホテル（兵庫・神戸市）
  • Year and Date: 2015-07-03
• [Presentation] 急性網膜壊死が疑われた眼サルコイドーシスの一例． (2015)
  • Author(s): 上村朋世、八木橋めぐみ、横井匡、仁科幸子、東 範行
  • Organizer: 第71回日本弱視斜視学会総会・第40回日本小児眼科学会総会合同学会
  • Place of Presentation: ポートピアホテル（兵庫・神戸市）
  • Year and Date: 2015-07-03
• [Presentation] ヒトiPS細胞から網膜神経節細胞の作製. (2015)
  • Author(s): 東 範行
  • Organizer: 第71回日本弱視斜視学会総会・第40回日本小児眼科学会総会合同学会 千寿製薬研究所セミナー
  • Place of Presentation: ポートピアホテル（兵庫・神戸市）
  • Year and Date: 2015-07-03
• [Presentation] 小児眼科分野の最近の話題. (2015)
  • Author(s): 東 範行
  • Organizer: 第8回Tokyo West Ophthalmic Conference.
  • Place of Presentation: 渋谷エクセルホテル東急（東京・渋谷区）
  • Year and Date: 2015-05-13
  • Invited
• [Presentation] サブスペシャリティーサンデー 「視機能・小児眼科・眼腫瘍」 (2015)
  • Author(s): 東 範行
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: ロイトン札幌（北海道・札幌市）
  • Year and Date: 2015-04-16
• [Presentation] Best of AAO 弱視斜視・小児・神経眼科． (2015)
  • Author(s): 仁科幸子
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: ロイトン札幌(北海道・札幌市）
  • Year and Date: 2015-04-16
• [Book] 小児眼科学 (2015)
  • Author(s): 東 範行
  • Total Pages: 570
  • Publisher: 三輪書店, 東京
• [Patent(Industrial Property Rights)] 視神経細胞の作製方法 (2015)
  • Inventor(s): 東 範行・横井 匡・田中 卓
  • Industrial Property Rights Holder: 国立成育医療研究センター・千寿製薬
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-08-07
  • Overseas