| Budget Amount *help |
¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2016: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
We tested the hypothesis that SNPs in IL10, IL19, IL20, and IL24 of the IL10 family gene alter clinical outcome of septic shock. Patients with septic shock (n=1,193) were genotyped for 13 tag SNPs of IL10, IL19, IL20, and IL24. IL20 gene expression was measured in lymphoblastoid cells in vitro. Cardiac surgical ICU patients (n=981) were genotyped for IL20 rs2981573 A/G.
Patients with the G allele of IL20 rs2981573 had a significantly increased 28-day mortality compared to A allele in septic shock (adjusted HR 1.27; p=8.0×10-4). Patients with the GG genotype had more organ dysfunction (p<0.05). The GG genotype was associated with increased IL20 gene expression in stimulated lymphoblastoid cells in vitro (p<0.05). The cardiac surgical ICU patients with the GG genotype had an increased ICU stay (p=0.032). The GG genotype of IL20 rs2981573 SNP was associated with increased IL20 gene expression and increased adverse outcomes in patients with septic shock and following cardiac surgery.
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