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Statistical Science of Bioinformatics

Research Project

Project/Area Number 15H02669
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research InstitutionOsaka University

Principal Investigator

Kano Yutaka  大阪大学, 基礎工学研究科, 教授 (20201436)

Co-Investigator(Kenkyū-buntansha) 乾 敏郎  追手門学院大学, 心理学部, 教授 (30107015)
春野 雅彦  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報工学研究室, 研究マネージャー (40395124)
野村 泰伸  大阪大学, 基礎工学研究科, 教授 (50283734)
村田 昇  早稲田大学, 理工学術院, 教授 (60242038)
森川 耕輔  大阪大学, 基礎工学研究科, 助教 (40824305)
小林 康  大阪大学, 生命機能研究科, 准教授 (60311198)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords巡回因果モデル / 欠測値データ解析 / メタアナリシス / 統計的因果推論 / fMRIデータ / 脳科学・脳情報 / causality / missingness / cyclic model / big data / sparse modeling / 欠測データと生体情報 / スパースコーディング / 測定誤差 / Causal inference / Bayesian inference / うつ病 / 多重指標 / missing data analysis / ランダムネスの効用 / 脳情報 / 欠測値データ / モデル選択 / 一般化線形混合モデル / セミパラメトリック法 / 強化学習 / ワーキングメモリ / 脳信号 / 順序カテゴリカルデータ / 脳科学 / 多次元尺度法 / 項目反応理論 / 脳内ネットワーク
Outline of Final Research Achievements

We can summarize our research results as nine categories. In particular, results on the missing data analysis and meta analysis are influential. For the results to obtain, we have organized and offered five international symposiums and a domestic one in the research period. Each of the symposiums consisted of 3 to 20 presenters. In addition, we have hosted small size colloquiums 13 times in Osaka University, where totally 15 speakers were invited; and essential discussions in the colloquiums helped to proceed and complete our research.

Academic Significance and Societal Importance of the Research Achievements

社会的かつ学術的に最も顕著な研究成果は巡回因果モデルの開発である.循環する可能性のある因果関係は社会的に大きな需要があるにもかかわらず,その基本的なコンセプトが成熟しなかったが故に,研究対象となることが殆ど無かった.本研究において発展させられた非線形関係を想定するモデルは,巡回因果モデルによる解析の嚆矢となることが期待される.欠測・欠損データ解析での理論研究は今までの学術研究を完全化させることに貢献する.また,欠測・欠損データ解析のための(数学的)条件を緩和することは,その適用範囲を広げることであり,応用にも貢献できる可能性がある.

Report

(5 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (53 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (5 results) Journal Article (17 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 16 results,  Open Access: 12 results,  Acknowledgement Compliant: 4 results) Presentation (26 results) (of which Int'l Joint Research: 13 results,  Invited: 4 results) Funded Workshop (5 results)

  • [Int'l Joint Research] Iowa State University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Yonsei University/Gachon University(韓国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Notre Dame/California State University(U.S.A.)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] U of Notre Dame/U British Columbia(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Iowa State U(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A least squares-type density estimator using a polynomial function2020

    • Author(s)
      Im, J., Morikawa, K., and Ha, H.-T.
    • Journal Title

      Computational Statistics and Data Analysis

      Volume: 144 Pages: 106882-106882

    • DOI

      10.1016/j.csda.2019.106882

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Full Moon and Out-of-Hospital Cardiac Arrest in Japan ― Population-Based, Double-Controlled Case Series Analysis ―2019

    • Author(s)
      Sado Junya、Morikawa Kosuke、Hattori Satoshi、Kiyohara Kosuke、Matsuyama Tasuku、Izawa Junichi、Iwami Taku、Kitamura Yuri、Sobue Tomotaka、Kitamura Tetsuhisa
    • Journal Title

      Circulation Reports

      Volume: 1 Issue: 5 Pages: 212-218

    • DOI

      10.1253/circrep.CR-18-0030

    • NAID

      130007644550

    • ISSN
      2434-0790
    • Year and Date
      2019-05-10
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 欠測データ解析のmissとmyth2019

    • Author(s)
      狩野 裕
    • Journal Title

      日本統計学会誌

      Volume: 48(2) Pages: 199-214

    • NAID

      130007724376

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transport analysis of infinitely deep neural network2019

    • Author(s)
      Sonoda, S.and Murata, N.
    • Journal Title

      Journal of Machine Learning Research

      Volume: 20(2) Pages: 1-52

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meta analytical SEM: Equivalence between maximum likelihood and generalized least squares2018

    • Author(s)
      Yuan, K.-H. and Kano, Y.
    • Journal Title

      Journal of Educational and Behavioral Statistics

      Volume: 43(6) Issue: 6 Pages: 639-720

    • DOI

      10.3102/1076998618787799

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bias reduction using surrogate endpoints as auxiliary variables2018

    • Author(s)
      Takagi, Y. and Kano, Y.
    • Journal Title

      Annals of the Institute of Statistical Mathematics

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Missing data mechanisms and homogeneity of means and variances-covariances2018

    • Author(s)
      Ke-Hai Yuan, Mortaza Jamshidian and Yutaka Kano
    • Journal Title

      Psychometrika

      Volume: 印刷中 Issue: 2 Pages: 425-442

    • DOI

      10.1007/s11336-018-9609-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An Interpersonal Sentiment Quantification Method Applied to Work Relationship Prediction2017

    • Author(s)
      Miyuki Imada, Kei Hirose, Manabu Yoshida, Sun Yong Kim, Naoya Toyozumi, Guillaume Lopez, and Yutaka Kano
    • Journal Title

      NTT Technical Review

      Volume: 15 Pages: 1-14

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Brain response patterns to economic inequity predict present and future depression indices2017

    • Author(s)
      Toshiko Tanaka, Takao Yamamoto, Masahiko Haruno
    • Journal Title

      Nature Human Behaivior

      Volume: 1 Issue: 10 Pages: 748-756

    • DOI

      10.1038/s41562-017-0207-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identifiability of nonrecursive structural equation models2017

    • Author(s)
      Nagase, M. and Kano, Y.
    • Journal Title

      Statistics and Probability Letter

      Volume: 122 Pages: 109-117

    • DOI

      10.1016/j.spl.2016.11.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reinforcement learning for stabilizing an inverted pendulum naturally leads to intermittent feedback control as in human quiet standing2016

    • Author(s)
      Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura
    • Journal Title

      Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2016

      Volume: - Pages: 37-40

    • DOI

      10.1109/embc.2016.7590634

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The pedunculopontine tegmental nucleus as a motor and cognitive interface between the cerebellum and basal ganglia2016

    • Author(s)
      Fumika Mori, Ken-ichi Okada, Taishin Nomura, Yasushi Kobayashi
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 10 Pages: 109-109

    • DOI

      10.3389/fnana.2016.00109

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reward and Behavioral Factors Contributing to the Tonic Activity of Monkey Pedunculopontine Tegmental Nucleus Neurons during Saccade Tasks2016

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 10 Pages: 1-8

    • DOI

      10.3389/fnsys.2016.00094

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A powerful test for Balaam's design2015

    • Author(s)
      Mori, J. and Kano, Y.
    • Journal Title

      Pharmaceutical Statistics

      Volume: 14 Issue: 6 Pages: 464-470

    • DOI

      10.1002/pst.1703

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An entropy-based approach to path analysis of structural generalized linear models: a basic idea2015

    • Author(s)
      Nobuoki, Eshima, Minoru Tabata, Claudio Giovanni Borroni, Yutaka Kano,
    • Journal Title

      Entropy

      Volume: 17 Issue: 7 Pages: 5117-5132

    • DOI

      10.3390/e17075117

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Rhythmic Firing of Pedunculopontine Tegmental Nucleus Neurons in Monkeys during Eye Movement Task.2015

    • Author(s)
      Okada KI, Kobayashi Y.
    • Journal Title

      PLoS One

      Volume: 10(6):e0128147 Issue: 6 Pages: 110-110

    • DOI

      10.1371/journal.pone.0128147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gap Effect Abnormalities during a Visually Guided Pro-Saccade Task in Children with Attention Deficit Hyperactivity Disorder.2015

    • Author(s)
      Matsuo Y, Watanabe M, Taniike M, Mohri I, Kobashi S, Tachibana M, Kobayashi Y, Kitamura Y.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: 110-110

    • DOI

      10.1371/journal.pone.0125573

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Applying statistical approach to topic analysis for more comprehensive and appropriate modeling2020

    • Author(s)
      Harada, N., Yamashita, K., Motomura, Y. and Kano, Y.
    • Organizer
      CDMA2020
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Variational inference for nonparametric Bayesian bi-clustering model with Pitman-Yor process2019

    • Author(s)
      Li, JiYao and Kano, Y.
    • Organizer
      IBIS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A data-driven approach for reconstructing bifurcation diagrams of discrete dynamical systems2019

    • Author(s)
      Ohigashi, H., Nomura, T. and Nakamura, T.
    • Organizer
      IEEE LifeTec2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bias Correction for the Distribution of Aftershocks Within Short-Term Period Immediately After Large Mainshock2019

    • Author(s)
      Morikawa, K., Nagao, H., Ito, S., Sakai, S. and Hirata, N.
    • Organizer
      AOGS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Semiparametric optimal estimation with nonignorable nonresponse data2018

    • Author(s)
      Kim, J.-K. and Morikawa, K.
    • Organizer
      EcoSta2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Covariate Balancingに基づいた高次元データにおける頑健な因果効果の推定2018

    • Author(s)
      寺田 亘・濵田悦生
    • Organizer
      第12回日本統計学会春季集会 ポスターセッション
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cyclic Structural Equation Models and Their Identifiability2017

    • Author(s)
      Nagase, M. and Kano, Y.
    • Organizer
      ISI Regional Statistics Conference
    • Place of Presentation
      Bali (Indonesia)
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cyclic Nonlinear Structural Equation Models2017

    • Author(s)
      Nagase, M. and Kano, Y.
    • Organizer
      Joint Statistical Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 補助変数のスクリーニング法について2017

    • Author(s)
      伊森晋平・寺田吉壱
    • Organizer
      2017年度統計関連学会連合大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nonparametric causal inference by the kernel method2017

    • Author(s)
      Matsuoka, Y. and Hamada, E.
    • Organizer
      The 10th Conference of the IASC-ARS
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A robust model selection criterion family and its application for the causal model2017

    • Author(s)
      Kurata, S. and Hamada, E.
    • Organizer
      Conference of the International Federation of Classification Societies
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ソーシャルネットワーキングサービスの神経科学2017

    • Author(s)
      春野雅彦・森数馬
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 社会脳科学の最近の発展2017

    • Author(s)
      春野雅彦
    • Organizer
      生命体工学セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病患者における反復経頭蓋磁気刺激治療前後の眼球運動評価2017

    • Author(s)
      齋藤洋一,宇賀 太一,船本 万里 ,森 風美加,平石 幹,岡田 研一,小林 康,眞野 智生
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] congeniality と over-imputation を用いた傾向スコアの推定2017

    • Author(s)
      森川遼真・森川耕輔・狩野 裕
    • Organizer
      第11回日本統計学会春季集会 ポスターセッション
    • Place of Presentation
      政策研究大学(東京都・港区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Semiparametric Efficient Estimation Under Nonignorable Nonresponse I2016

    • Author(s)
      Morikawa, K. and Kim, J. K.
    • Organizer
      KAIST Statistical Workshop
    • Place of Presentation
      Daejeon (Korea)
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Comparisons Among Doubly Robust Estimators in Restricted Moment Models2016

    • Author(s)
      林 暢哉・狩野 裕
    • Organizer
      2016年度統計関連学会連合大会
    • Place of Presentation
      金沢大学(石川県・金沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] A New Information Criterion for Ignorable Missing Data2016

    • Author(s)
      Morikawa, K., Imori, S. and Kano, Y.
    • Organizer
      IC-SMHD-2016
    • Place of Presentation
      Cappadocia (Turkey)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An information criterion for partially prediction with incomplete data2016

    • Author(s)
      Imori, S. and Shimodaira, H.
    • Organizer
      IC-SMHD-2016
    • Place of Presentation
      Cappadocia (Turkey)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 回帰モデルの選択規準と外れ値に対するロバスト性の検証2016

    • Author(s)
      倉田澄人,濵田悦生
    • Organizer
      第10回日本統計学会春季集会 ポスターセッション
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] ダイバージェンスに基づいたロバストなモデル選択について2016

    • Author(s)
      倉田澄人,濵田悦生
    • Organizer
      シンポジウム「欠測データ解析とモデル選択:生体情報データの統計モデル」
    • Place of Presentation
      大阪大学(大阪府豊中市)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非逐次モデルの識別性について2015

    • Author(s)
      長瀬真利雄,狩野 裕
    • Organizer
      2015年度統計関連学会連合大会
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 一般化線形混合モデルにおけるランダム効果の分布の誤特定による推定への影響2015

    • Author(s)
      坂口弘樹,狩野 裕
    • Organizer
      2015年度統計関連学会連合大会
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 順序のあるカテゴリカルデータに対するノンパラメトリックベイズモデリング2015

    • Author(s)
      上野真依,狩野 裕
    • Organizer
      2015年度統計関連学会連合大会
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 不完全データにおける情報量規準2015

    • Author(s)
      森川耕輔・伊森晋平・狩野 裕
    • Organizer
      日本行動計量学会第43回大会
    • Place of Presentation
      首都大学東京(東京都八王子市)
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Developments in multivariate missing data analysis2015

    • Author(s)
      Kano, Y.
    • Organizer
      International Meeting of the Psychometric Society 2015
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Funded Workshop] The 87th Open Seminar on Data Science2019

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Causal inference and cyclic models2019

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] "Bayesian inference and model selection" IFCS20172017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] "Causal inference and related topics" IFCS20172017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] Missing-data Analysis and SEM2016

    • Place of Presentation
      金沢大学(石川県・金沢市)
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2022-11-04  

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