Construction of analyses basis for understanding rare variants using protein structural information
| Project/Area Number |
15H02773
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRAI TSUYOSHI 長浜バイオ大学, バイオサイエンス学部, 教授 (00262890)
OHTA MOTONORI 名古屋大学, 大学院情報科学研究科, 教授 (40290895)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 低頻度変異 / タンパク質立体構造 / ホモロジーモデリング / ヒトタンパク質 / レアバリアント / 変異の意味づけ / ゲノム変異 / 蛋白質立体構構造 / バイオインフォマティクス / 蛋白質立体構造 / ヒトゲノム / 変異 |
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| Outline of Final Research Achievements |
We could construct the proposed systems as planned, which can map genetic variations onto protein structures, and the results are available through the web site called snvmap. For the purpose, we generated model structures of human proteins, if they are not available in PDB.
By using the mapping results, we performed statistical analyses and found some interesting rare variations related with the metabolism of oseltamivir, an anti-virus drug, which specific for east Asian populations.
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Report
(4 results)
Research Products
(15 results)
