Mecahistic analysis of a protective response of skin tissue to UV genotoxicity
| Project/Area Number |
15H02815
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 隆史 東北大学, 医学系研究科, 講師 (70508308)
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| Co-Investigator(Renkei-kenkyūsha) |
MORITA Masanobu 東北大学, 医学系研究科, 助教 (10519094)
YAMAMOTO Masayuki 東北大学, 医学系研究科, 教授 (50166823)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 紫外線 / 皮膚 / MIS応答 / アポトーシス / 突然変異 / DNA損傷 / 遺伝子組換えマウス / Nrf2 / 活性酸素 / 環境応答 / 細胞・組織 / Mrf2 / 環境 / 細胞･組織 |
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| Outline of Final Research Achievements |
We studied the mechanism of the response of mutation induction suppression (MIS), a protective response of skin tissue to UV genotoxicity, using a mechanistic model based on the Keap1-Nrf2 system, which controls antioxidative responses in mammalian cells. We performed an analysis of global gene expression changes in the MIS response and detected the induction of genes related to apoptosis and cell proliferation, which suggests that MIS is based on a tissue turnover mechanism with apoptosis and hyperplasia. The analysis has also suggested that the Keap1-Nrf2 system functions in the tissue recovery process from the skin damage produced after UV exposures. We also estimated the amounts of UV-induced DNA damage necessary for the MIS induction.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response2016
Author(s)
Saito R, Suzuki T, Hiramoto K, Asami S, Naganuma E, Suda H, Iso T, Yamamoto H, Morita M, Baird L, Furusawa Y, Negishi T, Ichinose M, Yamamoto M.
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Journal Title
Molecular and Cellular Biology.
Volume: 36
Issue: 2
Pages: 271-284
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Characterization of three major cysteine sensors of Keap1 in stress response.2016
Author(s)
T. Suzuki, R. Saito, K. Hiramoto, S. Asami, E. Naganuma, H. Suda, T. Iso, H. Yamamoto, M. Morita, L. Baird, Y. Furusawa, T. Negishi, M. Ichinose, M. Yamamoto
Organizer
The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
Place of Presentation
仙台国際センター（仙台市）
Year and Date
2016-05-20
Related Report
Int'l Joint Research / Invited
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