| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Outline of Final Research Achievements |
Ionizing radiation is considered to produce mutant somatic cells, the number of which is proportional to the radiation dose, resulting in cancer risk that is proportional to the dose. A direct proof of this hypothesis would be facilitated by visualization of somatic cells harboring cancer-causing mutations. Establishment of such technology will be dependent on the development of animal carcinogenesis models where the cancer-causing mutation is locatable in the genome of somatic cells, like genetic knockout models. To this end, the current project succeeded in establishing a novel knockout rat model with increased cancer susceptibility after exposure to ionizing radiation.
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