| Project/Area Number |
15H02825
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
石塚 真由美 北海道大学, 獣医学研究院, 教授 (50332474)
水川 葉月 北海道大学, 獣医学研究院, 助教 (60612661)
中山 翔太 北海道大学, 獣医学研究院, 助教 (90647629)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | DDT・IRS / ベクターコントロール / マラリア / 誘導性肝臓様細胞 / Vector Control / DDT / 室内限定散布 / リスク評価 / ケミカルハザード / オミクス / ADME / 極新鮮肝Bank / iHep / 野生動物 / 感受性評価 / 化学物質感受性評価 / 希少野生動物 / 異物代謝系 / 極新鮮肝 |
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| Outline of Final Research Achievements |
In this study, attention was paid to the KwaZulu-Natal state in South Africa, a vector control area in Africa, and its threat situation was investigated and toxicity impact assessment was conducted on living organisms.
As a result of investigation focusing on poultry, the DDT concentration in the liver showed a very high value of 920 ng / g ww in the median and 14,400 ng / g ww in the maximum value. As a result of gene expression analysis by real-time RT-PCR method, it became clear that it affected genetic group involved in lipid metabolism, synthesis and sex steroid hormone synthesis. The results of this study suggest that DDT gives certain effects to the living body, suggesting the need to implement more appropriate Vector control in the future.
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