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Detection of highly functional polyphenols produced in the reactions of food cooking and processing and their application for the prevention of life-style related diseases

Research Project

Project/Area Number 15H02892
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits
Research InstitutionOsaka City University

Principal Investigator

Masuda Toshiya  大阪市立大学, 大学院生活科学研究科, 教授 (10219339)

Co-Investigator(Kenkyū-buntansha) 田村 啓敏  香川大学, 農学部, 教授 (00188442)
Research Collaborator Oyama Yasuo  徳島大学
Masuda Akiko  四国大学
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywordsポリフェノール / 調理加工 / 生活習慣病予防 / 焙煎 / コーヒー / 痛風 / 焙煎加工 / コーヒーポリフェノール / キサンチンオキシダーゼ阻害 / 高温加工 / ドッキングシミュレーション / 食品調理加工 / 高温反応 / 機能発現機構 / ピロガロール / 微量定量分析 / 生活習慣病 / 化学変化 / XO阻害 / ルテオリン
Outline of Final Research Achievements

Food cooking and processing are essential processes from raw foodstuff to eatable food. This study was carried out regarding that such processes are the conversion reactions of the constituents of foodstuff to food functional substances. Among various cooking and processing, roasting was selected and coffee was also selected as the food which required roasting as its important processing. Epidemiologic studies have shown that the coffee drinking habit can reduce the risk of gout and hyperuricemia, therefore, xanthine oxidase (XO) inhibitory activity, which was related to prevention of gout, was examined in detected new substances in the roasting reaction. As the results, various chlorogenic lactones, pyrogallol, and vinylcatechol oligomers were detected and their XO inhibitory activity were evaluated.

Academic Significance and Societal Importance of the Research Achievements

食材を食物とするために必須な調理・加工操作は人類発祥時から,様々な新技術が開発されてきているが,現代人の食による健康維持の期待には対応していなかった。本研究により,調理・加工自体を,化学反応の場として捉え,食材成分を変化させることにより有用な食品機能を発生させる一例を示すことができた。この研究をさらに発展させれば,起源の怪しい食材ではなく,確かな食材から調理加工という反応により,健康に資する食品を創り出すことができ,また食品加工産業において,新たな機能性食品開発法として応用できる。加えて,生活習慣病に悩む現代人のニーズに応える新しい調理・加工法の実現にもつながる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (30 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Stability of Polyphenols under Alkaline Conditions and the Formation of a Xanthine Oxidase Inhibitor from Gallic Acid in a Solution at pH 7.42019

    • Author(s)
      Honda Sari、Ishida Rika、Hidaka Kayo、Masuda Toshiya
    • Journal Title

      Food Science and Technology Research

      Volume: 25 Issue: 1 Pages: 123-129

    • DOI

      10.3136/fstr.25.123

    • NAID

      130007607026

    • ISSN
      1344-6606, 1881-3984
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radical Scavenging Properties of Roasted Egoma (<i>Perilla frutescens</i> var. <i>frutescens</i>) Oils and Identification of Their Characteristic Scavengers2018

    • Author(s)
      AKiko Masuda, Kayo Hidaka, Sari Honda, Asami Taniguchi, Sayaka Doi, Toshiya Masuda,
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 64 Issue: 6 Pages: 466-472

    • DOI

      10.3177/jnsv.64.466

    • NAID

      130007599105

    • ISSN
      0301-4800, 1881-7742
    • Year and Date
      2018-12-31
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] コーヒー豆中のキサンチンオキシダーゼ阻害物質 ―コーヒーの痛風発症リスク軽減効果の解明を目指してー2018

    • Author(s)
      増田晃子,福山侑弥,本田沙理,飛高佳代,増田俊哉
    • Journal Title

      New Food Industry

      Volume: 60 Pages: 1-6

    • NAID

      40021645273

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コーヒー焙煎加工で生成するポリフェノールは痛風発症リスク軽減に寄与するか?焙煎コーヒー豆中のキサンチンオキシダーゼ阻害物質の同定2018

    • Author(s)
      本田沙理,増田俊哉
    • Journal Title

      Foods & Food Ingregients Journal of Japan

      Volume: 223 Pages: 367-375

    • NAID

      40021744578

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Zinc-dependent and independent actions of hydroxyhydroquinone on rat thymic lymphocytes2018

    • Author(s)
      Honoka Wada, Keisuke Oyama, Risa Kamae, Toshiya Masuda, Kaori Kanemaru, Kumio Yokoigawa and Yasuo Oyama
    • Journal Title

      Drug and Chemical Toxicology

      Volume: 9 Issue: 5 Pages: 1-6

    • DOI

      10.1080/01480545.2018.1429462

    • NAID

      120006560582

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Xanthine Oxidase (XO) inhibitory phenylindanes produced by thermal reaction of caffeic acid2018

    • Author(s)
      Yuya Fukuyama, Kayo Hidaka, Akiko Masuda, and Toshiya Masuda
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 82 Issue: 10 Pages: 1825-1828

    • DOI

      10.1080/09168451.2018.1491287

    • NAID

      120006712081

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019685

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conflicting actions of 4-vinylcatechol in rat lymphocytes under oxidative stress induced by hydrogen peroxid2018

    • Author(s)
      Takumi Kishida, Yurie Funakoshi, Yuya Fukuyama, Sari Honda, Toshiya Masuda & Yasuo Oyama
    • Journal Title

      Drug and Chemical Toxicology

      Volume: - Issue: 4 Pages: 1-6

    • DOI

      10.1080/01480545.2018.1492604

    • NAID

      120006706954

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes2017

    • Author(s)
      Risa Kamae, Shoko Nojima, Kenji Akiyoshi, Shoki Setsu, Sari Honda, Toshiya Masuda and Yasuo Oyama
    • Journal Title

      Food and Chemical Toxicology

      Volume: 102 Pages: 39-45

    • DOI

      10.1016/j.fct.2017.01.025

    • NAID

      120006382862

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conversion to purpurogallin, a key step in the mechanism of the potent xanthine oxidase inhibitory activity of pyrogallol2017

    • Author(s)
      Sari Honda; Yuya Fukuyama; Hisashi Nishiwaki; Akiko Masuda; Toshiya Masuda
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 106 Pages: 228-235

    • DOI

      10.1016/j.freeradbiomed.2017.02.037

    • NAID

      120006712077

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019852

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Pyrogallol in the Ethyl Acetate-Soluble Part of Coffee as the Main Contributor to Its Xanthine Oxidase Inhibitory Activity2016

    • Author(s)
      S. Honda,T. Masuda
    • Journal Title

      J. Agric. Food Chem.

      Volume: 64 Issue: 41 Pages: 7743-7749

    • DOI

      10.1021/acs.jafc.6b03339

    • NAID

      120006712078

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019935

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An oxidative coupling product of luteolin with cysteine ester and its enhanced inhibitory activity for xanthine oxidase2015

    • Author(s)
      Toshiya Masuda, ,Shoko Nojima, Yukari Miura, Sari Honda, Akiko Masud
    • Journal Title

      Bioorg. Medicinal Chem. Lett.

      Volume: 25 Issue: 16 Pages: 3117-3119

    • DOI

      10.1016/j.bmcl.2015.06.016

    • NAID

      120006712091

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019678

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Polyphenols: Functional Chemicals Based on Their Chemical Reactions, from Antioxidation to Inter-Substance Reactions2015

    • Author(s)
      本田沙理,増田俊哉
    • Journal Title

      KAGAKU TO SEIBUTSU

      Volume: 53 Issue: 7 Pages: 442-448

    • DOI

      10.1271/kagakutoseibutsu.53.442

    • NAID

      130005157297

    • ISSN
      0453-073X, 1883-6852
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 超浅煎り焙煎コーヒー豆に含まれるキサンチンオキシダーゼ阻害物質の探索2018

    • Author(s)
      本田沙理,福山侑弥,増田晃子,増田俊哉
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カフェ酸の加熱反応により生成するビニルカテコール型キサンチンオキシダーゼ阻害剤の同定2018

    • Author(s)
      福山侑弥,本田沙理,増田晃子,増田俊哉
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] 異なる加熱温度におけるカフェ酸加熱生成物の構造相違とキサンチンオキシダーゼ阻害2018

    • Author(s)
      福山侑弥,本田沙理,増田晃子,増田俊哉
    • Organizer
      日本栄養食糧学会72回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 超浅煎り焙煎コーヒー豆に含まれるキサンチンオキシダーゼ阻害物質の探索2018

    • Author(s)
      本田沙理,福山侑弥,西脇寿,増田晃子,増田俊哉
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スクロースの高温加熱によって生じるポリフェノールーHHQより疎水性のポリフェノールの同定―2017

    • Author(s)
      野島祥子,亀田和美,増田俊哉
    • Organizer
      日本農芸化学会2016年度 大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 焙煎コーヒーに発見された強力なキサンチンオキシダーゼ阻害活性物質・ピロガロールの活性発現機構(その1)2017

    • Author(s)
      本田沙理,福山侑弥,西脇寿,増田晃子,増田俊哉
    • Organizer
      日本農芸化学会2016年度 大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポリフェノールの反応性に基づく食品機能の解明2017

    • Author(s)
      増田俊哉
    • Organizer
      「バイオマテリアルインターフェース先端マテリアルの創製」第7回シンポジウム
    • Place of Presentation
      あべのメディクス(大阪府大阪市)
    • Year and Date
      2017-02-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 焙煎コーヒーの強力なXOI物質・ピロガロールの活性発現機構研究(2)ピロガロールおよび酸化物のドッキングシミュレーション2017

    • Author(s)
      本田沙理,福山侑弥,西脇寿,増田晃子,増田俊哉
    • Organizer
      第71回日本栄養食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 焙煎コーヒーのキサンチンオキシダーゼ阻害機能-ピロガロールおよびクロロゲン酸ラクトンの寄与評価-2016

    • Author(s)
      本田沙理,福山侑弥,本村衛由,友久 結,増田俊哉,増田晃子
    • Organizer
      第49回日本栄養食糧学会中国・四国支部大会
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糖質の加熱における機能性ポリフェノールの生成―加熱条件とHHQの生成―2016

    • Author(s)
      野島祥子,増田俊哉,岡村雄
    • Organizer
      日本農芸化学会2016年度
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] コーヒーの酢酸エチル可溶画分のキサンチンオキシダーゼ阻害物質-ピロガロールおよびその酸化物の活性について-2016

    • Author(s)
      本田沙理1,2,増田俊哉1,増田晃子
    • Organizer
      日本農芸化学会2016年度
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of chlorogenic acid lactones as xanthine oxidase inhibuitors produced during the roasting process of coffee beans2015

    • Author(s)
      Sari Honda, Akiko Masuda, Kento Moriyama, Toshiya Masuda
    • Organizer
      12th Asian congress of nutrition
    • Place of Presentation
      Pacifico Yokohama(神奈川県横浜市)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 食品機能化学研究室ホームページ

    • URL

      https://foodchem-ocu.jimdo.com/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] キサンチンオキシダーゼ阻害剤2018

    • Inventor(s)
      本田 沙理 増田 俊哉 藤井 繁佳 黒澤 真一郎
    • Industrial Property Rights Holder
      本田 沙理 増田 俊哉 藤井 繁佳 黒澤 真一郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-046920
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] キサンチンオキシダーゼ阻害剤及びその製造法2018

    • Inventor(s)
      福山 郁弥 本田 沙理 増田 俊哉 藤井 繁佳 黒澤 真一郎
    • Industrial Property Rights Holder
      福山 郁弥 本田 沙理 増田 俊哉 藤井 繁佳 黒澤 真一郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-046921
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] キサンチンオキシダーゼ阻害剤2018

    • Inventor(s)
      本田沙理, 増田俊哉, 藤井繁佳, 黒澤真一郎
    • Industrial Property Rights Holder
      本田沙理, 増田俊哉, 藤井繁佳, 黒澤真一郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] キサンチンオキシダーゼ阻害剤及びその製造法2018

    • Inventor(s)
      福山郁弥,本田沙理,増田俊哉,藤井繁佳,黒澤真一郎
    • Industrial Property Rights Holder
      福山郁弥,本田沙理,増田俊哉,藤井繁佳,黒澤真一郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] キサンチンオキシダーゼ阻害剤2015

    • Inventor(s)
      本田沙理,増田俊哉,藤井繁佳,黒澤真一郎
    • Industrial Property Rights Holder
      本田沙理,増田俊哉,藤井繁佳,黒澤真一郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-09-04
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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