| Budget Amount *help |
¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
|
|---|
| Outline of Final Research Achievements |
Epidemiological studies indicated that disturbed circadian rhythm caused by night shift work is a potential risk factor for breast cancer and cardiovascular diseases. In this study, we investigated influences of nocturnal light exposure on thrombosis factors in male C3H/He mice and those of light and dark cycle shift on atherosclerosis and breast cancer metastasis using female BALB/c.KOR/StmSLc-ApoEshl mice and BALB/c mice injected BJMC3879luc2 breast cancer cells, respectively. And chemopreventive effect of quercetin, a dietary flavonoid, was also studied. Nocturnal light exposure for 3 h affected expression of Pai-1, tPA and TF genes related to thrombogenesis in the heart. Circadian dysfunction did not affect development of atherosclerosis and primary tumor growth, however, increased the number of lymph node with metastasis. 0.1% quercetin diet suppressed expression of genes related to metastasis in the tumor. Effect of quercetin on lymphangiogenesis is under investigation.
|
