| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
The epigenetic profile of the developing fetus is sensitive to environmental influence. Maternal body mass index (BMI) and nutrition has been shown to influence DNA methylation patterns in offspring, but research in humans is limited. Therefore, we developed a pregnancy and delivery database (n=742) and methylation levels in the cord blood of newborns were determined using the Illumina HumanMethlylation450K Beadchip. The main findings are: 1) pre-pregnancy maternal BMI and the risk of low birth weight (LBW), 2) low socioeconomic status and the risk of LBW, 3) associations between maternal BMI groups and variations in newborn blood DNA methylation. Based on findings from this database, we will provide useful information for nutrition education pre- and during pregnancy.
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