Development of functional food based on the improvement of mitochondrial dysfunction to prevent lifestyle related diseases
| Project/Area Number |
15H02902
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Tokai University |
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Principal Investigator |
Nagai Ryoji 東海大学, 農学部, 教授 (20315295)
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| Co-Investigator(Kenkyū-buntansha) |
松村 剛 熊本大学, 大学院生命科学研究部(医), 准教授 (20398192)
小野 政輝 東海大学, 農学部, 教授 (60177269)
坂田 則行 福岡大学, 医学部, 教授 (20134273)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | ミトコンドリア / 翻訳語修飾 / バイオマーカー / 生活習慣病 / 翻訳後修飾 / 疾病予防 / メイラード反応後期生成物 / 2SC |
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| Outline of Final Research Achievements |
We previously revealed that S-(2-succinyl) cysteine (2SC) accumulation in adipocyte is associated with mitochondrial dysfunction caused by hyperglycemia. In this study, analysis method of 2SC, which was considered to be difficult to measure, was further improved and it provides stable results with even 1uL of serum. It was demonstrated that some lifestyle related diseases such as diabetes are associated with 2SC accumulation in vivo and 2SC level in mice varies by organs. Furthermore, some extract from natural products shows inhibitory effects on 2SC formation. These results indicate that regular intake of effective compounds could help us to stay away from lifestyle related diseases such as diabetes complications.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] <i>Aphanothece sacrum</i> (Sur.) Okada Prevents Cataractogenesis in Type 1 Diabetic Mice2017
Author(s)
Matsuda S, Sugawa H, Shirakawa J, Ohno R, Kinoshita S, Ichimaru K, Arakawa S, Nagai M, Kabata K, Nagai R
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 63
Issue: 4
Pages: 263-268
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access
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[Journal Article] Involvement of a gut?retina axis in protection against dietary glycemia-induced age-related macular degeneration2017
Author(s)
(10)Rowan S, Jiang S, Korem T, Szymanski J, Chang ML, Szelog J, Cassalman C, Dasuri K, McGuire C, Nagai R, Du XL, Brownlee M, Rabbani N, Thornalley PJ, Baleja JD, Deik AA, Pierce KA, Scott JM, Clish CB, Smith DE, Weinberger A, Avnit-Sagi T, Lotan-Pompan M, Segal E, Taylor A
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Journal Title
Proceedings of the National Academy of Sciences
Volume: 114
Issue: 22
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Salacia chinensis L. extract ameliorates abnormal glucose metabolism and improves the bone strength and accumulation of AGEs in type 1 diabetic rats2016
Author(s)
Shirakawa J, Arakawa S, Tagawa T, Gotoh K, Oikawa N, Ohno R, Shinagawa M, Hatano K, Sugawa H, Ichimaru K, Kinoshita S, Furusawa C, Yamanaka M, Kobayashi M, Masuda S, Nagai M, Nagai R
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Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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