| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We previously revealed that S-(2-succinyl) cysteine (2SC) accumulation in adipocyte is associated with mitochondrial dysfunction caused by hyperglycemia. In this study, analysis method of 2SC, which was considered to be difficult to measure, was further improved and it provides stable results with even 1uL of serum. It was demonstrated that some lifestyle related diseases such as diabetes are associated with 2SC accumulation in vivo and 2SC level in mice varies by organs. Furthermore, some extract from natural products shows inhibitory effects on 2SC formation. These results indicate that regular intake of effective compounds could help us to stay away from lifestyle related diseases such as diabetes complications.
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