Molecular Nutritional Regulation of Sterol Metabolism and Atherosclerosis
| Project/Area Number |
15H02903
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Chubu University |
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Principal Investigator |
YOKOYAMA Shinji 中部大学, 生物機能開発研究所, 客員教授 (10142192)
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| Co-Investigator(Kenkyū-buntansha) |
中川 大 中部大学, 応用生物学部, 准教授 (40397039)
呂 鋭 中部大学, 応用生物学部, 講師 (80381862)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | コレステロール / 動脈硬化 / HDL / 栄養学的制御 / 栄養因子 / 動脈硬化症 / ステロール代謝 / ABCA1 / Atherosclerosis / apoA-I / apoA-II / probucol |
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| Outline of Final Research Achievements |
We investigated nutritional regulation of cholesterol metabolism and achieved that; 1) for its catabolic pathway ABCA1 activity for HDL biogenesis is down regulated in diabetes by (1) its impairment of transport to the cell surface by high glucose concentraiton and by enhanced degradation through advanced glycated end-product receptor pathway, and (2) ABCA1 degradation is enhanced by its interaction with caveolin 1 and its interception results in the increase of ABCA1 activity; 2) bioinformatic analysis revealed continuous increase of plasma HDL in the past two decades among Japanese and definite differentiates of structure, function and risk for atherosclerosis of HDL defined by HDL protein composition.
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| Academic Significance and Societal Importance of the Research Achievements |
コレステロール代謝は動脈硬化を始めとする生活習慣病の発症と密接な関連があり、その栄養学的制御機構の解明は我が国の疾病予防による健康長寿と医療費削減を達成する上で重要な研究課題である。本研究により、１）動脈硬化の負のリスク因子である血漿HDL産生の栄養学的制御に新たな知見を得たこと、２）疫学的情報の bioinformatics 手法による解析により、HDLの構造・機能・代謝について重要な発見がなされた。これらの知見に基づいて我が国動脈硬化予防のあらたな戦略を構築する方向性が得られた。
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State2017
Author(s)
Takashi Miida, Kunihiro Nishimura, Satoshi Hirayama, Yoshihiro Miyamoto, Masakazu Nakamura, Daisaku Masuda, Shizuya Yamashita, Shoji Ushiyama, Naohisa Fujita, Shinji Yokoyama, Tamio Teramoto
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 24
Issue: 6
Pages: 583-599
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Open Access
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[Journal Article] Probucol-Oxidized Products, Spiroquinone and Diphenoquinone, Promote Reverse Cholesterol Transport in Mice2016
Author(s)
Yakushiji E, Ayaori M, Nishida T, Shiotani K, Takiguchi S, Nakaya K, Uto-Kondo H, Ogura M, Sasaki M, Yogo M, Komatsu T, Lu R, Yokoyama S, Ikewaki K
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 36
Issue: 4
Pages: 591-597
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum2015
Author(s)
Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S.
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Journal Title
J Biol Chem
Volume: 290
Issue: 39
Pages: 23464-23477
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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