| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
We investigated nutritional regulation of cholesterol metabolism and achieved that; 1) for its catabolic pathway ABCA1 activity for HDL biogenesis is down regulated in diabetes by (1) its impairment of transport to the cell surface by high glucose concentraiton and by enhanced degradation through advanced glycated end-product receptor pathway, and (2) ABCA1 degradation is enhanced by its interaction with caveolin 1 and its interception results in the increase of ABCA1 activity; 2) bioinformatic analysis revealed continuous increase of plasma HDL in the past two decades among Japanese and definite differentiates of structure, function and risk for atherosclerosis of HDL defined by HDL protein composition.
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