| Budget Amount *help |
¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
There are emerging evidences for epigenetic inheritance of metabolic stresses in the parental generation to the offsprings. Part of these stresses can be ameliorated by dietary polyphenols. We have found that co-administration of trans-resveratrol (RSV) could reduce alcoholic fatty liver in male mice. We then crossed these males with normal females and found that serum triacylglycerol level was higher in the offsprings of ethanol treated (E) males than in those of control (C) males, while it was unchanged in those of ethanol + RSV treated (ER) males. The offsprings' liver exhibited transcriptomic segregation between C- and E-groups but not between C- and ER-groups. Then we analyzed genome-wide cytosine methylation in the fathers' sperm and in the offsprings' liver. There were significant differences in methylated cytosine distribution among C-, E- and ER- groups. It is possible that these epigenetic modifications can be transduced to the next generation to cause metabolic phenotypes.
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