Study on maintenance of descendant's health by non-nutritional food components through epigenetics
| Project/Area Number |
15H02905
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Kanagawa Institute of Industrial Sclence and Technology (2017)
Kanagawa Academy of Science and Technology (2015-2016) |
|---|
Principal Investigator |
Yasuoka Akihito 地方独立行政法人神奈川県立産業技術総合研究所, 食品機能性評価グループ, 研究員(任期有) (10453028)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KONDHO Takashi 理化学研究所, 統合生命医科学研究センター, 上級研究員 (40333299)
OKADA Shinji 東京大学, 大学院・農学生命科学研究科, 准教授 (50376563)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
|---|
| Keywords | エピジェネティクス / 食品ポリフェノール / トランスクリプトーム / 代謝ストレス / 食と栄養 / 機能性食品 / 分子代謝学 / 発現制御 |
|---|
| Outline of Final Research Achievements |
There are emerging evidences for epigenetic inheritance of metabolic stresses in the parental generation to the offsprings. Part of these stresses can be ameliorated by dietary polyphenols. We have found that co-administration of trans-resveratrol (RSV) could reduce alcoholic fatty liver in male mice. We then crossed these males with normal females and found that serum triacylglycerol level was higher in the offsprings of ethanol treated (E) males than in those of control (C) males, while it was unchanged in those of ethanol + RSV treated (ER) males. The offsprings' liver exhibited transcriptomic segregation between C- and E-groups but not between C- and ER-groups. Then we analyzed genome-wide cytosine methylation in the fathers' sperm and in the offsprings' liver. There were significant differences in methylated cytosine distribution among C-, E- and ER- groups. It is possible that these epigenetic modifications can be transduced to the next generation to cause metabolic phenotypes.
|
Report
(4 results)
Research Products
(17 results)
-
-
-
-
[Journal Article] Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.2016
Author(s)
Kozuka C, Shimizu-Okabe C, Takayama C, Nakano K, Morinaga H, Kinjo A, Fukuda K, Kamei A, Yasuoka A, Kondo T, Abe K, Egashira K, Masuzaki H.
-
Journal Title
Drug Deliv.
Volume: 24
Issue: 1
Pages: 558-568
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high-fat diet.2016
Author(s)
Kamei, A., Watanabe, Y., Shinozaki, F., Yasuoka, A., Shimada, K., Kondo, K., Ishijima, T., Toyoda, T., Arai, S., Kondo, T., and Abe, K.
-
Journal Title
Mol. Nutr. Food Res.
Volume: 61
Issue: 2
Pages: 1-15
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species.2016
Author(s)
Shinozaki F, Abe T, Kamei A, Watanabe Y, Yasuoka A, Shimada K, Kondo K, Arai S, Kumagai K, Kondo T, Abe K.
-
Journal Title
Genes Nutr.
Volume: 11
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Administration of a maple syrup extract to mitigate their hepatic inflammation induced by a high-fat diet: a transcriptome analysis.2015
Author(s)
Kamei, A., Watanabe, Y., Shinozaki, F., Yasuoka, A., Kondo, T., Ishijima, T., Toyoda, T., Arai, S., and Abe, K.
-
Journal Title
Biosci. Biotechnol. Biochem.
Volume: 79
Issue: 11
Pages: 1893-1897
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
