| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Outline of Final Research Achievements |
We have clearly revealed that a thermo-sensor TRPV4 (activated above 34°C) is activated by physiological temperature in hippocampal neurons and thereby controls their excitability. Therefore, if local brain temperature could dynamically elevate depending on the neuronal activities, a thermo-sensor TRPV4 can enhance electrical excitability in neurons, and might lead to hyperexcitability. In this study, we focused on epilepsy, since it was caused by hyperexcitability of neurons. We generated a model of partial epilepsy in wild type (WT) or TRPV4KO mice, and measured electroencephalogram (EEG). The frequencies of epileptic EEG in WT mice were significantly larger than those in TRPV4KO mice. These results strongly indicate that TRPV4 activation is involved in disease progression of epilepsy. We expected that the disease progression enhanced hyperexcitability, and lead to hyperthermia in the epileptogenic zones.
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