Biomedical engineering-based analysis of the molecular mechanisms underlying functional crosstalk between muscle and neurons.
| Project/Area Number |
15H03011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Chubu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
水村 和枝 中部大学, 生命健康科学部, 教授 (00109349)
片野坂 友紀 岡山大学, 医歯(薬)学総合研究科, 助教 (60432639)
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| Research Collaborator |
HIBINO Yuhei
SHIMIZU Rie
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 骨格筋 / 侵害受容器 / 一次知覚神経 / メカノバイオロジー / メカノセンサー / 筋肉痛 / 伸張受容器 / 伸長受容器 |
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| Outline of Final Research Achievements |
Mechanotransduction is important to maintain the muscle functions. However, its molecular basis remains largely elusive. The aims of this study were to reveal mechanisms of mechanotransduction of muscle and innervated sensory neuron, and to understand their functional interaction. We constructed an experimental system to characterize the cellular mechanical responses of cultured muscle sensory neurons. We also analyzed molecular mechanisms of adaptive effect of the repeated bout of exercise on muscle pain, and examined the phenotypes of skeletal muscle-specific or sensory neuron-specific knockout mice of a mechanosensor. We found that this molecule is essential for mechanotransduction of the muscle sensory neuron and myocyte. In addition, we found that a membrane repair protein was increased in the muscle after exercise, suggesting its adaptive effect on muscle pain. These results might support to develop the preventive care of locomotive syndrome and pain relief.
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Report
(4 results)
Research Products
(10 results)
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[Presentation] Peripheral pain mechanisms via neurotrophic factors in a rat reserpine-induced fibromyalgia model2017
Author(s)
Wakatsuki, K., Matsubara, T., Katanosaka, K., Yamanaka, A., Nishijo, H., Mizumura, K., Taguchi, T.
Organizer
第94回日本生理学会大会
Place of Presentation
アクトシティー浜松（静岡県・浜松市）
Year and Date
2017-03-28
Related Report
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[Presentation] Nerve growth factor-mediated mechanism,but not muscle damage, is required for the induction of delayed onset muscle soreness in rats.2015
Author(s)
Hayashi, K., Katanosaka, K., Abe, M., Yamanaka, A., Mizumura, K. and Taguchi, T.
Organizer
第38回日本神経科学会
Place of Presentation
神戸国際会議場・国際展示場（兵庫県神戸市）
Year and Date
2015-07-29
Related Report
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