| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Mechanotransduction is important to maintain the muscle functions. However, its molecular basis remains largely elusive. The aims of this study were to reveal mechanisms of mechanotransduction of muscle and innervated sensory neuron, and to understand their functional interaction. We constructed an experimental system to characterize the cellular mechanical responses of cultured muscle sensory neurons. We also analyzed molecular mechanisms of adaptive effect of the repeated bout of exercise on muscle pain, and examined the phenotypes of skeletal muscle-specific or sensory neuron-specific knockout mice of a mechanosensor. We found that this molecule is essential for mechanotransduction of the muscle sensory neuron and myocyte. In addition, we found that a membrane repair protein was increased in the muscle after exercise, suggesting its adaptive effect on muscle pain. These results might support to develop the preventive care of locomotive syndrome and pain relief.
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