Development of transscleral multi-drug delivery device for retinal disease treatment
| Project/Area Number |
15H03015
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 薬物送達 / 生体材料 / 眼科学 / 網膜 / ドラッグデリバリーシステム / 臨床応用 / 経強膜投与 / 薬学 / バイオテクノロジー / 網膜疾患 / DDS |
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| Outline of Final Research Achievements |
Purpose is the evaluation of a transscleral multi-drug delivery device for clinical practice. We developed a flexible device that can fit on the curvature of the eyeball by using a silicon material and stainless wire. Pharmacokinetics in the eye was evaluated for 1 year using rabbits and monkeys. Safety in the retinal function 1 year after device implantation was confirmed. Pharmacological effects in transgenic retinal degeneration model rabbits was confirmed. Scar formation around the device did not affect the retinal function. Enhanced drug delivery by simultaneous cyclosporine A release was indicated. Devices for clinical use was stable for 24 months and safe biologically.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Long-term Protection of Genetically-Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery2017
Author(s)
Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 57(15)
Issue: 15
Pages: 6527-6538
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Protective Effects of Sustained Unoprostone Release Device in Rhodopsin Pro347Leu Transgenic Rabbits2016
Author(s)
Nobuhiro Nagai, Yasuko Izumida, Hirokazu Kaji, Matsuhiko Nishizawa, Aya Katsuyama, Shinji Yamada, Toru Nakazawa, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toshiaki Abe
Organizer
2016 ARVO annual meeting
Place of Presentation
Seattle, Washington, USA
Year and Date
2016-05-01
Related Report
Int'l Joint Research
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[Presentation] Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device2015
Author(s)
Nobuhiro Nagai, Yasuko Izumida, Eri Koyanagi, Hirokazu Kaji, Matsuhiko Nishizawa, Takahito Imagawa, Akiko Morikawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe
Organizer
2015 ARVO annual meeting
Place of Presentation
Denver, Colorado, USA
Year and Date
2015-05-03
Related Report
Int'l Joint Research
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