Development of porous metallic biomaterials with high strength, low elastic modulus and excellent biocompatibility

• Project/Area Number: 15H03016
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: Xie Guoqiang 東北大学, 多元物質科学研究所, 産学官連携研究員 (50422134)
• Co-Investigator(Kenkyū-buntansha): 金高 弘恭 東北大学, 歯学研究科, 准教授 (50292222)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 金属ガラス / ポーラス材料 / 放電プラズマ焼結法 / 生体・医療材料 / 微細構造 / 強度 / ヤング率 / 気孔率 / 機械的特性

Outline of Final Research Achievements

Porous Ni- and Be-free Ti-based bulk metallic glass (BMG) with a diameter exceeding 15 mm was developed by spark plasma sintering (SPS) the mixture of gas-atomized Ti-based glassy alloy powder and solid salt (NaCl) powder, followed by leaching treatment to eliminate the salt phase. The developed porous Ti-based BMG alloy exhibited high yield strength, simultaneously matched the Young’s modulus of natural bone, and demonstrated high corrosion resistance and excellent biocompatibility. These results suggest that porous Ti-based BMGs produced by the SPS process open an advanced alternative for clinical applications under load-bearing conditions such as surgical implants.

Research Products

• [Journal Article] Manufacturing of Cu-based metallic glasses matrix composites by spark plasma sintering (2018)
  • Author(s): S. Cardinal, J.M. Pelletier, G.Q. Xie and F. Mercier
  • Journal Title: Mater. Sci. Eng. A Volume: 711 Pages: 405-411
  • DOI: 10.1016/j.msea.2017.11.052
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Formation of nanostructured metallic glass thin films upon sputtering (2017)
  • Author(s): Ketov Sergey V.、Joksimovic Rastko、Xie Guoqiang、Trifonov Artem、Kurihara Kazue、Louzguine-Luzgin Dmitri V.
  • Journal Title: Heliyon Volume: 3 Issue: 1 Pages: e00228-e00228
  • DOI: 10.1016/j.heliyon.2016.e00228
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhanced mechanical properties, corrosion behavior and bioactivity of Ti-based bulk metallic glasses with minor addition elements (2016)
  • Author(s): F.X. Qin, Y. Zhou, C. Ji, Z.H. Dan, G.Q. Xie and S. Yang
  • Journal Title: Acta Metallurgica Sinica (English Letters) Volume: 29 Issue: 11 Pages: 1011-1018
  • DOI: 10.1007/s40195-016-0468-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Corrosion behavior, mechanical properties and cell cytotoxity of Zr-based bulk metallic glasses (2016)
  • Author(s): B.R. Guan, X.T. Shi, Z.H. Dan, G.Q. Xie, M. Niinomi and F.X. Qin
  • Journal Title: Intermetallics Volume: 72 Pages: 69-75
  • DOI: 10.1016/j.intermet.2016.02.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nanoindentation studies of the effects of ion irradiation on the near surface mechanical response of annealed Ti40Cu32Pd14Zr10Sn2Si2 metallic glass ribbons (2016)
  • Author(s): A. Zare, M.J. Klopfstein, D.A. Lucca, L. Price, L. Shao and G.Q. Xie
  • Journal Title: Journal of Tribology Volume: 138 Issue: 4
  • DOI: 10.1115/1.4032820
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In vivo evaluation of a Ti-based bulk metallic glass alloy bar (2015)
  • Author(s): R. Kokubun, W. Wang, S.L. Zhu, G.Q. Xie, S. Ichinose, S. Itoh and K. Takakuda
  • Journal Title: Bio-Medical Materials and Engineering Volume: 26 Issue: 1-2 Pages: 9-17
  • DOI: 10.3233/bme-151546
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of minor additions on Ni- and Be-free Ti-based bulk glassy alloys (2015)
  • Author(s): S.L. Zhu, G.Q. Xie, A. Inoue, Z.D. Cui, X.J. Yang and W. Zhang
  • Journal Title: Materials Science Forum Volume: 833 Pages: 79-84
  • DOI: 10.4028/www.scientific.net/msf.833.79
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Biocompatible bulk metallic glasses and the composites produced by spark plasma sintering (2018)
  • Author(s): G.Q. Xie, H. Kanetaka, F.X. Qin, S.L. Zhu and W. Wang
  • Organizer: Structure, Properties and Dynamics of Glasses
  • Int'l Joint Research / Invited
• [Presentation] 放電プラズマ焼結法による多孔質チタン基金属ガラスの機械的特性に及ぼす気孔サイズの影響 (2017)
  • Author(s): 謝国強、高田朝、金高弘恭
  • Organizer: 粉体粉末冶金協会2017年春季大会
• [Presentation] Improvement and characterization of Ti-based bulk metallic glasses for application as biomedical materials (2017)
  • Author(s): G.Q. Xie, S.L. Zhu, F.X. Qin, H. Takada, H. Kanetaka and W. Wang
  • Organizer: International Conference on Frontiers in Materials Processing Application, Research & Technology
  • Int'l Joint Research / Invited
• [Presentation] 放電プラズマ焼結法による多孔質チタン基金属ガラスの機械的性質に及ぼす気孔率の影響 (2017)
  • Author(s): 謝国強、金高弘恭
  • Organizer: 日本金属学会2017年秋期（第161回）大会
• [Presentation] Biocompatible Ti-based bulk metallic glassy composites produced by spark plasma sintering (2017)
  • Author(s): G.Q. Xie, S.L. Zhu and H. Kanetaka
  • Organizer: JSPM International Conference on Powder and Powder Metallurgy (JSPMIC2017)
  • Int'l Joint Research
• [Presentation] Evaluation of biocompatible Ti-based bulk metallic glasses (2016)
  • Author(s): G.Q. Xie, H. Kanetaka, F.X. Qin, S.L. Zhu and W. Wang
  • Organizer: Energy Materials Nanotechnology (EMN) Meeting on Metallic Glasses
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2016-09-12
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of Ni- and Be-free porous Ti-based bulk metallic glasses for application as biomaterials (2016)
  • Author(s): G.Q. Xie, F.X. Qin, W. Wang , H. Takada and H. Kanetaka
  • Organizer: 23rd International Symposium on Metastable, Amorphous and Nanostrustured Materials (ISMANAM-2016)
  • Place of Presentation: Nara, Japan
  • Year and Date: 2016-07-03
  • Int'l Joint Research / Invited
• [Presentation] Property improvement of Ni- and Be-free Ti-based bulk metallic glasses for application as biomaterials (2016)
  • Author(s): G.Q. Xie, S.L. Zhu, F.X. Qin, W. Wang, H. Takada and H. Kanetaka
  • Organizer: Summit of Materials Science (SMS2016)
  • Place of Presentation: Tohoku University, Japan
  • Year and Date: 2016-05-18
  • Int'l Joint Research
• [Presentation] Porous bulk metallic glasses for application as biomedical materials (2016)
  • Author(s): G.Q. Xie, F.X. Qin, I. Seki and W. Wang
  • Organizer: TMS 2016: 145th Annual Meeting & Exhibition
  • Place of Presentation: Nashville, Tennessee, U.S.A.
  • Year and Date: 2016-02-14
  • Int'l Joint Research / Invited
• [Presentation] 金属ガラスの医療応用に関する研究 (2016)
  • Author(s): 謝国強
  • Organizer: 日本鉄鋼協会 鉄系金属ガラスの粘性流動成形技術開発研究会 平成28年度第3回研究会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] 生体適合高性能Ti基金属ガラス合金の改善と評価 (2015)
  • Author(s): 謝国強、秦風香、朱勝利、関一郎、新家光雄、王巍、高久田和夫、塙隆夫、松下伸広、塚本雅裕
  • Organizer: 特異構造金属・無機融合高機能材料開発共同研究プロジェクト第6回6大学6研究所連携プロジェクト公開討論会
  • Place of Presentation: 東北大学、仙台
  • Year and Date: 2015-11-20
• [Presentation] 溶液プロセスによるTi基金属ガラス表面への酸化亜鉛含有ナノメッシュ酸化物層の形成 (2015)
  • Author(s): 松戸亮、生駒俊之、松下伸広、謝国強、新家光雄
  • Organizer: 特異構造金属・無機融合高機能材料開発共同研究プロジェクト第6回6大学6研究所連携プロジェクト公開討論会
  • Place of Presentation: 東北大学、仙台
  • Year and Date: 2015-11-20
• [Presentation] 塩素フリーフラックスによるチタンの還元と不純物分離プロセスの構築 (2015)
  • Author(s): 関一郎、謝国強、山浦真一
  • Organizer: 特異構造金属・無機融合高機能材料開発共同研究プロジェクト第6回6大学6研究所連携プロジェクト公開討論会
  • Place of Presentation: 東北大学、仙台
  • Year and Date: 2015-11-20
• [Presentation] 放電プラズマ焼結で作製した多孔質チタン基金属ガラスの特性評価 (2015)
  • Author(s): 謝国強、秦風香、王巍、金高弘恭
  • Organizer: 粉体粉末冶金協会2015年秋季大会
  • Place of Presentation: 京都大学、京都
  • Year and Date: 2015-11-11
• [Presentation] Characterization of Ni- and Be-free Ti-based bulk metallic glasses fabricated by spark plasma sintering (2015)
  • Author(s): G.Q. Xie, S.L. Zhu, F.X. Qin, W. Wang and I. Seki
  • Organizer: 3rd International Conference on Powder Metallurgy in Asia (APMA2015)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Development of biocompatible bulk metallic glasses (2015)
  • Author(s): G.Q. Xie, F.X. Qin, S.L. Zhu and W. Wang
  • Organizer: Advanced Materials & Surface Modification International Conference (AMSMIC)
  • Place of Presentation: Qingdao, P. R. China
  • Year and Date: 2015-10-29
  • Int'l Joint Research / Invited
• [Presentation] Biocompatible titanium-based bulk metallic glasses (2015)
  • Author(s): G.Q. Xie, S.L. Zhu, F.X. Qin and W. Wang
  • Organizer: 22nd International Symposium on Metastable, Amorphous and Nanostrustured Materials (ISMANAM-2015)
  • Place of Presentation: Paris, France
  • Year and Date: 2015-07-13
  • Int'l Joint Research / Invited
• [Presentation] Effects of minor additions on Ni- and Be-free Ti-based bulk glassy alloys for application as biomedical materials (2015)
  • Author(s): G.Q. Xie, S.L. Zhu, F.X. Qin, I. Seki, W. Wang, K. Takakuda, T. Hanawa, N. Matsushita and M. Tsukamoto
  • Organizer: The 6th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-6)
  • Place of Presentation: Waseda University, Japan
  • Year and Date: 2015-06-09
  • Int'l Joint Research
• [Presentation] Surface modification of Ti-based bulk metallic glass by solution process for bioactivity and antimicrobial property (2015)
  • Author(s): R. Matsudo, K. Katsumata, T. Ikoma, J. Tanaka, G.Q. Xie, M. Niinomi, and N. Matsushita
  • Organizer: The 6th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-6)
  • Place of Presentation: Waseda University, Japan
  • Year and Date: 2015-06-09
  • Int'l Joint Research
• [Presentation] Chlorine free manufacturing process of titanium for glassy alloys (2015)
  • Author(s): I. Seki, S. Yamaura and G.Q. Xie
  • Organizer: The 6th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-6)
  • Place of Presentation: Waseda University, Japan
  • Year and Date: 2015-06-09
  • Int'l Joint Research