Development of immunoceramics acting on immune system and their functions
| Project/Area Number |
15H03025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Meiji University |
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Principal Investigator |
Aizawa Mamoru 明治大学, 理工学部, 専任教授 (10255713)
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| Co-Investigator(Kenkyū-buntansha) |
永井 重徳 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50348801)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 免疫療法 / イムノセラミックス / ゾル-ゲル法 / 水酸アパタイト / ホウ素含有アパタイト / 免疫細胞 / T細胞 / フローサイトメーター / 養子免疫療法 / 生体材料 / バイオセラミックス / アパタイト / イノシトールリン酸 |
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| Outline of Final Research Achievements |
Hydroxyapatite (HAp) are one of the important key materials in the field of biomaterials. Recently, immunotherapy without side effects has been expected as a novel medical treatment for a cancer. In order to create the novel cell-culture substrates for enhancing the activity of immune cells, we have developed the two types “immunoceramics” on the bases of i) boron-containing apatite (BAp) with BO2 groups and ii) HAp ceramics surface-modified with inositol phosphate (IP6) (hereafter, IP6-HAp ceramics). Splenocytes derived from the spleen of mouse were seeded on these immnoceramics to examine the activation ability using a flow cytometry. The results showed that the populations of splenocytes with the immunoceramics were higher than that of the splenocytes with the HAp ceramics as a control. The present two immunoceramics may be expected as key materials for next-generation immunotherapy for a cancer.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Delayed Propionibacterium acnes surgical site infections occur only in the presence of an implant2016
Author(s)
Y. Shiono, K. Ishii, S. Nagai, H. Kakinuma, A. Sasaki, H. Funao, T. Kuramoto1, K. Yoshioka, H. Ishihama, N. Isogai, K. Takeshima, T. Tsuji, Y. Okada, S. Koyasu, M. Nakamura, Yoshiaki Toyama, M. Aizawa, and M. Matsumoto
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 32758-32758
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel hydroxyapatite film coated with ionic silver via inositol hexaphosphate chelation prevents implant-associated infection.2016
Author(s)
Funao H, Nagai S, Sasaki A, Hoshikawa T, Tsuji T, Okada Y, Koyasu S, Toyama Y, Nakamura M, Aizawa M, Matsumoto M, Ishii K.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 23238-23238
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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