Design of Spatiotemporally Controllable Smart Medical Systems Using Dynamic Cross-linked Gels
| Project/Area Number |
15H03026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kansai University |
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Principal Investigator |
Miyata Takashi 関西大学, 化学生命工学部, 教授 (50239414)
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| Co-Investigator(Kenkyū-buntansha) |
川崎 英也 関西大学, 化学生命工学部, 教授 (50322285)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 刺激応答性ゲル / 動的架橋 / 生体分子複合体 / DDS / 細胞制御 / センサーチップ / 分子認識 / 表面パターン |
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| Outline of Final Research Achievements |
In this study, dynamic gels were designed using biomolecular complexes and photo-dimerization as dynamic cross-links, and spatiotemporally controllable medical systems were developed using their gels. Dynamic gels with model drugs as dynamic cross-links regulated the drug release by the conformational change of the gel networks. Dynamic gels with molecular recognition sites were formed on gold sensor chips, enabling us to detect a target biomolecule sensitively and selectively. Biomolecule- and photo-responsive dynamic gels were strategically designed as smart scaffolds for regulating cell behavior.
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Report
(4 results)
Research Products
(69 results)
