High sensitivity spin detection

• Project/Area Number: 15H03035
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Nagasaki International University (2016-2017); Kyushu University (2015)
• Principal Investigator: Ichikawa Kazuhiro 長崎国際大学, 薬学部, 教授 (10271115)
• Co-Investigator(Kenkyū-buntansha): 安川 圭司 第一薬科大学, 薬学部, 准教授 (80372738)
• Research Collaborator: NAGANUMA TATSUYA 日本レドックス株式会社, 開発部長 ; TAMURA CHIHIRO 九州大学, 先端融合医療レドックスナビ研究拠点, テクニカルスタッフ ; TOKUNAGA YUUMI 九州大学, 先端融合医療レドックスナビ研究拠点, テクニカルスタッフ
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 磁気共鳴 / スピン / 計測 / イメージング / 磁化 / 炎症モデル / フリーラジカル / 電子スピン共鳴 / 物理化学 / 電子スピン計測

Outline of Final Research Achievements

In various diseases such as lifestyle diseases, it has become clear that excessive active oxygen production is involved in in vivo redox balance and is involved in disease formation. Although Overhauser effect MRI (OMRI) is a useful method for measurement of biological redox, there was a problem of sensitivity improvement.
In this research, in order to improve the sensitivity of biological redox measurement, we aimed to develop OMRI device system using high sensitive spin detection technique useful in low magnetic field region. Installation method of high sensitivity spin detector, magnetic shielding method was examined, and a detection system of i. d.70 mm was prototyped and it was clarified that it can be introduced into this system.

Research Products

• [Journal Article] Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice (2018)
  • Author(s): Kato N, Sato S, Yamada K, Ichikawa K
  • Journal Title: Applied Magnetic Resonance Volume: 印刷中 Issue: 8 Pages: 869-879
  • DOI: 10.1007/s00723-018-1004-3
  • Peer Reviewed
• [Journal Article] Hyperpolarized [1-13C]-pyruvate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts efficacy of targeting the Warburg effect (2018)
  • Author(s): Scroggins B, Matsuo M, White A, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Ichikawa K, Mitchell JB, Cherukuri MK, Citrin DE
  • Journal Title: Clinical Cancer Research Volume: 印刷中 Issue: 13 Pages: 3137-3148
  • DOI: 10.1158/1078-0432.ccr-17-1957
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution (2016)
  • Author(s): Yoichi Takakusagi, Kaori Inoue, Tatsuya Naganuma, Fuminori Hyodo, and Kazuhiro Ichikawa
  • Journal Title: J Magn Reson Volume: 270 Pages: 157-160
  • DOI: 10.1016/j.jmr.2016.07.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of a PET/OMRI combined system for simultaneous imaging of positron and free radical probes for small animals (2016)
  • Author(s): Seiichi Yamamoto, Tadashi Watabe, Hayato Ikeda, Yasukazu Kanai, Kazuhiro Ichikawa, Motonao Nakao, Katsuhiko Kato, Jun Hatazawa
  • Journal Title: Medical Physics Volume: 43 Issue: 10 Pages: 5676-5684
  • DOI: 10.1118/1.4963215
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design of a hyperpolarized (15)N NMR probe that induces a large chemical-shift change upon binding of calcium ions (2015)
  • Author(s): Ryunosuke Hata, Hiroshi Nonaka, Yoichi Takakusagi, Kazuhiro Ichikawa, Shinsuke Sando
  • Journal Title: Chem Commun (Camb) Volume: 51 Issue: 61 Pages: 12290-12292
  • DOI: 10.1039/c5cc04597e
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Development of high resolution DNP-MRI scanner for small animal imaging (2017)
  • Author(s): Kazuhiro Ichikawa
  • Organizer: International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems
  • Int'l Joint Research / Invited
• [Presentation] Development of DNP-MRI scanners at wide frequency range for biomedical application -from skin to large animal- (2016)
  • Author(s): Kazuhiro Ichikawa
  • Organizer: Molecular Photoscience Research Center International Workshop (MR-THz2016)
  • Int'l Joint Research / Invited
• [Presentation] Construction of Double-tuned Resonator for Overhauser MRI (2016)
  • Author(s): C. Tamura, T . Naganuma, M. Nakao, K. Ichikawa
  • Organizer: XXVIIth International Conference on Magnetic Resonance in Biological Systems
  • Int'l Joint Research
• [Presentation] Construction of 0.15 Tesla Overhauser enhanced MRI (2016)
  • Author(s): Y. Tokunaga, M. Nakao, T. Naganuma and K. Ichikawa
  • Organizer: International Society on Oxygen Transport to Tissue 2016
• [Presentation] OMRI多重共振器の開発 (2015)
  • Author(s): 田村千尋、長沼辰弥、中尾素直、市川和洋
  • Organizer: 第54回電子スピンサイエンス学会年会
  • Place of Presentation: 新潟
  • Year and Date: 2015-11-02
• [Presentation] Effect of the ionic charge of gadolinium complex for polarization and spin-lattice relaxation of [13C] hyperpolarized chemical probes after dissolution. (2015)
  • Author(s): Yoichi Takakusagi, Kaori Inoue, Tatsuya Naganuma, Fuminori Hyodo Kazuhiro Ichikawa
  • Organizer: 5th DNP symposium
  • Place of Presentation: Egmond Aan Zee, Netherlands
  • Year and Date: 2015-08-31
  • Int'l Joint Research