Development of ultrasound-responsive nanobubbles containing physiologically active gas and construction of disease treatment system
| Project/Area Number |
15H03037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
丸山 一雄 帝京大学, 薬学部, 教授 (30130040)
高木 教夫 東京薬科大学, 薬学部, 教授 (50318193)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI RYO 帝京大学, 薬学部, 准教授 (90384784)
NOMIZU MOTOYOSHI 東京薬科大学, 薬学部, 教授 (00311522)
TAKAHASHI YOKO 東京薬科大学, 薬学部, 教授 (30453806)
MARUYAMA TORU 熊本大学, 薬学部, 教授 (90423657)
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| Research Collaborator |
ISHIMA YU 徳島大学, 薬学部, 准教授
SAWADA HONOKA 東京薬科大学, 薬学部, 学部生
SASAYAMA MIZUKI 東京薬科大学, 薬学部, 学部生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 超音波 / ナノバブル / 一酸化窒素ガス / セラノスティクス / 生理活性ガス / バブルリポソーム / ナノ材料 / ドラッグデリバリーシステム |
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| Outline of Final Research Achievements |
Since nitric oxide (NO) is expected to be applied to various diseases including cardiovascular diseases, it is important to develop DDS technology to deliver NO to disease sites. In this research, we tried to develop a novel nanobubble with ultrasond-responsive nanobubbles encapsulating NO gas, succeeded in developing nanobubbles that enable NO gas delivery at the target site by ultrasound exposure transcutaneously. Indeed, this nanobubble was administered to hindlimb ischemic mouse model, and ultrasound exposure transcutaneously caused an increase in blood flow rate of ischemic site due to NO release at the site. Since this nanobubble enables ultrasound contrast imaging, it is expected to be useful for constructing noninvasive diagnostic and therapeutic (Theranostics) systems in ischemic and various diseases.
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Report
(4 results)
Research Products
(4 results)
