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Development of ultrasound-responsive nanobubbles containing physiologically active gas and construction of disease treatment system

Research Project

Project/Area Number 15H03037
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Negishi Yoichi  東京薬科大学, 薬学部, 准教授 (50286978)

Co-Investigator(Kenkyū-buntansha) 丸山 一雄  帝京大学, 薬学部, 教授 (30130040)
高木 教夫  東京薬科大学, 薬学部, 教授 (50318193)
Co-Investigator(Renkei-kenkyūsha) SUZUKI RYO  帝京大学, 薬学部, 准教授 (90384784)
NOMIZU MOTOYOSHI  東京薬科大学, 薬学部, 教授 (00311522)
TAKAHASHI YOKO  東京薬科大学, 薬学部, 教授 (30453806)
MARUYAMA TORU  熊本大学, 薬学部, 教授 (90423657)
Research Collaborator ISHIMA YU  徳島大学, 薬学部, 准教授
SAWADA HONOKA  東京薬科大学, 薬学部, 学部生
SASAYAMA MIZUKI  東京薬科大学, 薬学部, 学部生
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords超音波 / ナノバブル / 一酸化窒素ガス / セラノスティクス / 生理活性ガス / バブルリポソーム / ナノ材料 / ドラッグデリバリーシステム
Outline of Final Research Achievements

Since nitric oxide (NO) is expected to be applied to various diseases including cardiovascular diseases, it is important to develop DDS technology to deliver NO to disease sites. In this research, we tried to develop a novel nanobubble with ultrasond-responsive nanobubbles encapsulating NO gas, succeeded in developing nanobubbles that enable NO gas delivery at the target site by ultrasound exposure transcutaneously. Indeed, this nanobubble was administered to hindlimb ischemic mouse model, and ultrasound exposure transcutaneously caused an increase in blood flow rate of ischemic site due to NO release at the site. Since this nanobubble enables ultrasound contrast imaging, it is expected to be useful for constructing noninvasive diagnostic and therapeutic (Theranostics) systems in ischemic and various diseases.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2018 2017

All Presentation (3 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 一酸化窒素ガスを内封した超音波応答性バブルリポソームの開発2018

    • Author(s)
      根岸洋一、澤田ほのか、韮沢慧、異島優、髙橋葉子、笹山瑞紀、鈴木亮、丸山一雄、丸山徹
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 一酸化窒素ガス内封ナノ・マイクロバブルの調製と物性評価2017

    • Author(s)
      澤田ほのか、韮沢慧、異島優、髙橋葉子、鈴木亮、丸山一雄、新槇幸彦、丸山徹、 根岸洋一
    • Organizer
      第33回日本DDS学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of nitric oxide gas encapsulating liposomes2017

    • Author(s)
      Y. Negishi, H. Sawada, Y. Ishima, R. Suzuki, K. Maruyama, T, Maruyama, and Y. Endo-Takahashi
    • Organizer
      The 16th International Symposium on Advanced Technology (ISAT-16)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 一酸化窒素内包バブルリポソーム及びその利用2017

    • Inventor(s)
      根岸洋一
    • Industrial Property Rights Holder
      根岸洋一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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