• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The effective training and the mechanisms for recovery from muscle atrophy

Research Project

Project/Area Number 15H03042
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionOita University

Principal Investigator

Kawakami Keisuke  大分大学, 福祉健康科学部, 教授 (60195047)

Co-Investigator(Kenkyū-buntansha) 曽我部 正博  名古屋大学, 医学系研究科, 特任教授 (10093428)
Co-Investigator(Renkei-kenkyūsha) MURAKAMI Taro  至学館大学, 健康科学部, 教授 (10252305)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords筋萎縮 / 理学療法 / 筋衛星細胞 / 筋肥大 / 理学療法学 / リハビリテーション / 医学・福祉 / 筋
Outline of Final Research Achievements

We aimed to determine the optimum training intensity for muscle atrophy. Muscle recovery assessed by maximal isometric contraction and myofiber cross‐sectional areas (CSAs) were facilitated at 40% and 60% maximum contraction strength (MC). Activation of myogenic satellite cells and a marked increase in myonuclei were observed at 40%, 60% MC. On the other hand, we aimed to examine the accumulation or degradation of damaged proteins after contractive activity and the following inactivity in cultured myotube. 2 days of repeated muscle contraction induced myotube hypertrophy. Damaged proteins were accumulated during the hypertrophy. When the contractile activities were stopped, autophagy was immediately activated and the damaged proteins were removed. Muscle inactive state is necessary to remove damaged proteins accumulated by repeated muscle contraction.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (16 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Post-injury stretch promotes recovery in a rat model of muscle damage induced by lengthening contractions2017

    • Author(s)
      Mori Tomohiro、Agata Nobuhide、Itoh Yuta、Inoue-Miyazu Masumi、Mizumura Kazue、Sokabe Masahiro、Taguchi Toru、Kawakami Keisuke
    • Journal Title

      The Journal of Physiological Sciences

      Volume: - Issue: 4 Pages: 1-10

    • DOI

      10.1007/s12576-017-0553-9

    • NAID

      40021574399

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Training at non-damaging intensities facilitates recovery from muscle atrophy.2017

    • Author(s)
      Itoh Y, Murakami T, Mori T, Agata N, Kimura N, Inoue-Miyazu M, Hayakawa K, Hirano T, Sokabe M, Kawakami K
    • Journal Title

      Muscle and Nerve

      Volume: 55(2) Issue: 2 Pages: 243-253

    • DOI

      10.1002/mus.25218

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] メカノバイオロジーに基づく筋力トレーニング-筋肥大と抗筋萎縮のメカニズムを探る-2016

    • Author(s)
      河上敬介,宮津真寿美
    • Journal Title

      医学のあゆみ

      Volume: 第257巻 第10号 Pages: 1079-1084

    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞移植治療後のデュシェンヌ型筋ジストロフィー症モデルマウスに対する等尺性収縮トレーニングは、移植による治療効果を促進する2017

    • Author(s)
      竹中菜々、伊東佑太、河上敬介、櫻井英俊
    • Organizer
      公益社団法人日本理学療法士協会 第52回日本理学療法学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疲労後の筋への定量圧刺激が運動機能と筋収縮様式に及ぼす影響2017

    • Author(s)
      川上健二、菅田陽怜、松下光次郎、池田尊司、河上敬介、片岡晶志、津村弘
    • Organizer
      公益社団法人日本理学療法士協会 第52回日本理学療法学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 理学療法の様々な領域に支援工学的視点をどう活かすか-日本基礎理学療法学会の視点から-2017

    • Author(s)
      河上敬介
    • Organizer
      公益社団法人日本理学療法士協会 第52回日本理学療法学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 筋の構造から考える理学療法の評価や治療2016

    • Author(s)
      河上敬介
    • Organizer
      一般社団法人京都府理学療法士会 生涯学習部第1回研修会
    • Place of Presentation
      京都大学(京都府京都市)
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] マウス足関節底屈筋群の遠心性筋収縮による筋損傷モデルの開発2016

    • Author(s)
      伊東佑太, 鈴木惇也, 縣信秀, 木村菜穂子, 平野孝行, 河上敬介
    • Organizer
      公益社団法人日本理学療法士協会 第51回日本理学療法学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-05-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 超音波刺激によって筋衛星細胞の増殖は促進される2016

    • Author(s)
      縣信秀, 宮津真寿美, 河上敬介
    • Organizer
      公益社団法人日本理学療法士協会 第51回日本理学療法学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Muscle-contraction training can enhance the efficacy cell transplantation treatment for Dunchenne Muscular Dystrophy(DMD)2016

    • Author(s)
      Nana Takenaka-Ninagawa, Yuta Itoh, Keisuke Kawakami, Hidetoshi Sakurai.
    • Organizer
      2nd International Symposium on Regenerative Rehabilitation in Kyoto
    • Place of Presentation
      Kyoto University(Japan, Kyoto)
    • Year and Date
      2016-03-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 理学療法的解剖学2015

    • Author(s)
      河上敬介
    • Organizer
      公益社団法人日本基礎理学療法学会第2回 日本基礎理学療法学会学術集会
    • Place of Presentation
      神奈川県立保健福祉大学(神奈川県横須賀市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 萎縮筋や損傷筋への力学刺激の与え方(肉眼解剖学、実験動物、培養細胞での腱鞘より)2015

    • Author(s)
      河上敬介
    • Organizer
      平成27年度第2回大分県理学療法士連盟研修会
    • Place of Presentation
      ホルトホール大分(大分県大分市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 筋損傷からの回復を促進させる超音波刺激はMyoD,myogenin量を亢進させる2015

    • Author(s)
      柴田 篤志,森 友洋,縣 信秀,宮本 靖義,宮津真寿美,馬路 祥子,河上 敬介
    • Organizer
      公益社団法人日本理学療法士協会第50回日本理学療法学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] The effective intensity of exercise load for facilitating recovery from muscle atrophy in mice2015

    • Author(s)
      Y Itoh, N Agata, N Kimura, M Inoue-Miyazu, T Hirano, K Hayakawa, T Murakami, K Kawakami.
    • Organizer
      The World Confederation for Physical Therapy Congress 2015
    • Place of Presentation
      Pan Pacific Singapore(Singapore)
    • Year and Date
      2015-05-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Muscle inactive state is necessary to remove damaged proteins accumulated by repeated muscle contraction.2015

    • Author(s)
      K Yoshioka, Y Adachi, M Inoue-Miyazu, N Agata, N Sasai, K Hayakawa, T Murakami, K Kawakami.
    • Organizer
      The World Confederation for Physical Therapy Congress 2015
    • Place of Presentation
      Pan Pacific Singapore(Singapore)
    • Year and Date
      2015-05-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] メカノバイオロジー2015

    • Author(s)
      曽我部正博、河上敬介、宮津真寿美
    • Total Pages
      22
    • Publisher
      化学同人
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi