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Development of internal fixation material that does not loosen for osteoporosis

Research Project

Project/Area Number 15H03056
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionIbaraki Prefectural University of Health Science

Principal Investigator

Mutsuzaki Hirotaka  茨城県立医療大学, 保健医療学部, 教授 (50550927)

Co-Investigator(Kenkyū-buntansha) 原 友紀  筑波大学, 医学医療系, 講師 (30431688)
Research Collaborator YAMAZAKI masashi  
ITO atsuo  
MURAI shinji  
FUJII kengo  
YANAGISAWA yohei  
MATSUMOTO yukei  
NAGASHIMA katsuya  
NOGUCHI hiroshi  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords線維芽細胞増殖因子 / 骨粗鬆症 / ハイドロキシアパタイト / 骨形成 / 線維芽細胞増殖因子-2 / ハイドロキシアパタイトコーティング / 内固定材料
Outline of Final Research Achievements

The effect verification of the pin for internal fixation coated with FGF-2-apatite composite layers (Ap-FGF) was performed using the osteoporosis rat. As a result, it was suggested that the Ap-FGF group had a high value of the fixation strength even in osteoporosis and suggested that the initial fixation was good. We clarified the Ap-FGF titanium screws on bone formation around the screw. These screws were implanted percutaneously in tibia of rabbits. Using inflammation-free histological sections, we histomorphometrically assessed them for the presence of bone formation. Weibull plot analysis was then applied to the data. The Ap-FGF titanium screws significantly reduced the risk of impaired bone apposition to the screw. Furthermore, the safety and efficacy of the Ap-FGF screw were examined using monkeys as human-like species. As a result, it was considered that the Ap-FGF screw was safe, and effective on bone formation.

Academic Significance and Societal Importance of the Research Achievements

共沈担持法でシグナル物質であるFGF-2を担持させ徐放させる技術を体内固定用ピンに応用したのは、我々が初である。本技術は全て薬事法上の認可物である医療用材料のみで施行可能であるため、薬事申請を目指す場合に非常に有利である。この材料の開発は、骨粗鬆症患者の骨において有効な固定力を有する内固定材料開発の第一歩となる。これにより、健康寿命の延伸、介護費用の削減が期待できる。高齢化先進国として世界に発信すべき新しい技術になると考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Reducing the risk of impaired bone apposition to titanium screws with the use of fibroblast growth factor-2-apatite composite layer coating.2017

    • Author(s)
      Fujii K, Ito A, Mutsuzaki H, Murai S, Sogo Y, Hara Y, Yamazaki M.
    • Journal Title

      Journal of Orthopaedic Surgery and Research

      Volume: 12(1) Issue: 1 Pages: 1-1

    • DOI

      10.1186/s13018-016-0501-z

    • NAID

      120007135220

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] FGF-2担持アパタイトコーティングチタンスクリューの安定した骨形成作用2016

    • Author(s)
      藤井賢吾、伊藤敦夫、原友紀、六崎裕高、村井伸司、柳澤洋平、長島克弥、松本佑啓、野口裕史、小林文子、十河友、山崎正志
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Optimal condition of fibroblast growth factor-2-apatite composite layer for superior osteogenesis and mechanical property2016

    • Author(s)
      藤井賢吾、六崎裕高、伊藤敦夫、村井伸司、柳澤洋平、十河友、原友紀、山﨑正志
    • Organizer
      2016 ORS Annual Meeting
    • Place of Presentation
      Disney’s Coronado Springs Resort, Orlando, Florida
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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