| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
This study aimed to investigate the role played by ribosome biogenesis in exercise-induced muscle hypertrophy using the rat skeletal muscles. A compensatory hypertrophy model, with which the degree of hypertrophy could be controlled, showed that both the ribosomal content and the expression of UBF (upstream binding factor), a transcription factor for rRNA, are strongly correlated with the degree of hypertrophy. In a resistance-training model, the muscle hypertrophy after the exercise period for 6 weeks showed a close association with the increase in ribosomal content. The ribosomal content increased at an early stage of training period (within 1 wk. after the initiation of training), and changed following a different time course from those of mTOR signal transduction activity and protein synthesis. These results suggest that the ribosomal content changes dynamically with the training stimulus, and the ribosomal biogenesis plays an important part in exercise-induced muscle hypertrophy.
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