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autophagy protein protects skeletal muscle atrophy

Research Project

Project/Area Number 15H03080
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionNagoya City University

Principal Investigator

okutsu Mitsuharu  名古屋市立大学, 大学院システム自然科学研究科, 講師 (80409755)

Co-Investigator(Renkei-kenkyūsha) NAGATOMI Ryoichi  東北大学, 大学院医学系研究科, 教授 (20208028)
IWATA Masahiro  日本福祉大学, 健康科学部, 准教授 (60448264)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords骨格筋 / 運動 / 抗酸化酵素 / 血管新生 / 生理学
Outline of Final Research Achievements

In this study, we used 3 complementary studies: i) C2C12 myotubes were subjected to uniaxial stretch to assess whether stretching regulates p62 expression; ii) C57BL/6 mice were assigned to either voluntary running or no exercise to examine whether exercise training regulates p62 protein; and iii) muscle-specific p62 knockout and wild-type littermates mice were assigned to either exercise training or sedentary groups, and the muscle content of antioxidants was determined after exercise training. Our results demonstrated that p62 mRNA levels were significantly increased by mechanical stretch in C2C12 myotubes. Voluntary running in C57BL/6 mice increased p62 protein and p62 phosphorylation in skeletal muscle. Loss of p62 in skeletal muscle also blunted the exercise training-mediated increase in antioxidants in skeletal muscle. These findings indicate that p62 is required for exercise training-mediated increase of antioxidants in skeletal muscle.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Presentation (10 results)

  • [Presentation] 運動が骨格筋の恒常性を維持する分子メカニズム2018

    • Author(s)
      奥津光晴
    • Organizer
      第22回日本体力医学会東海地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 運動が骨格筋の恒常性を調節する新規分子経路2017

    • Author(s)
      山田麻未,岩田全広,奥津光晴.
    • Organizer
      第21回日本体力医学会東海地方会学術集会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨格筋の恒常性維持に対する細胞ストレスセンサーの役割2017

    • Author(s)
      奥津光晴,山田麻未,岩田全広.
    • Organizer
      第21回日本体力医学会東海地方会学術集会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨格筋の恒常性維持に対する 細胞ストレスセンサーの役割2017

    • Author(s)
      奥津光晴 、山田麻未、岩田全広
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] オートファジー基質が骨格筋の抗酸化酵素を産生する新規分子基盤2017

    • Author(s)
      山田麻未、岩田全広、奥津光晴
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウェスタンブロットの注意点と成功するためのコツ2017

    • Author(s)
      奥津光晴、山田麻未
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨格筋細胞の収縮刺激によるSDF-1α/CXCL12の発現変化2016

    • Author(s)
      山田麻未,外園千紘,栗栖豊昌,岩田全広,奥津光晴.
    • Organizer
      第71回日本体力医学会学術集会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 一酸化窒素による抗酸化酵素の発現制御2016

    • Author(s)
      奥津光晴,栗栖豊昌,山田麻未,岩田全広.
    • Organizer
      第71回日本体力医学会学術集会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 運動トレーニングによるSDF-1α/CXCL12の発現動態と血管新生との関連2016

    • Author(s)
      外薗千紘,時澤健,丸井朱里,宇土泰希,岩田全広、鈴木克彦,永島計,奥津光晴
    • Organizer
      第20回日本体力医学会東海地方会
    • Place of Presentation
      中京大学八事キャンパス(愛知県名古屋市)
    • Year and Date
      2016-03-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨格筋のSDF-1α/CXCL12の発現動態と血管新生との関連2015

    • Author(s)
      外薗千紘,時澤健,丸井朱里,宇土泰希,鈴木克彦,永島計,奥津光晴
    • Organizer
      第70回日本体力医学会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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