| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
Skeletal muscle from exercised-trained subjects can display high insulin sensitivity, despite intramuscular lipid levels that exceed those of obese and diabetic individuals, a phenomenon described as the “athlete paradox”. However it is unknown whether exercises intensity is reflect to lipid alterations and insulin sensitivity. To clarify its mechanisms, we investigated PGC1 promoter methylation ratio and the role of exercise intensity on intramyocellular lipid level and insulin resistance. As a result, between the athlete and the control, there was a difference in the methylation rate on the PGC1 promoter. On the other hand, the composition of skeletal muscle intracellular lipid and blood lipid differed in change depending on exercise intensity. These results suggest that epigenetic regulation is one of the causes of athlete paradox and setting exercise intensity is important for prevention of metabolic syndrome.
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