| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Outline of Final Research Achievements |
Abnormal ventilation during exercise is one of the major manifestations of chronic heart failure (CHF). In this study, we developed an experimental animal model to investigate exercise hyperpnea in normal and CHF rats under anesthesia. In anesthetized rats, we induced muscle contraction by stimulating bi-lateral distal sciatic nerves at high and low voltage to mimic exercise. We recorded breath-by-breath respiratory gas analysis data. During muscle contraction, the controller curve shifted upward without change in central chemoreflex threshold, to compensate for the plant curve shift accompanying increased metabolism. Respiratory operating point were determined by integrating the controller and plant elements in the respiratory equilibrium diagram. In conclusion, investigation of respiratory regulation during exercise using the novel small animal experimental model will provide an opportunity to clarify the mechanisms of exercise hyperpnea.
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