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Motor memory and anti-oxidant agents

Research Project

Project/Area Number 15H03103
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Endo Shogo  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60192514)

Co-Investigator(Kenkyū-buntansha) 柳原 大  東京大学, 大学院総合文化研究科, 教授 (90252725)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords小脳 / 運動 / LTD / ROS / アスコルビン酸 / ビタミンE / 活性酸素種 / 運動学習 / 長期記憶 / 記憶 / 8-ニトロ-cGMP / プルキンエ細胞 / ビタミン
Outline of Final Research Achievements

Reactive oxygen species (ROS) are hazardous to induce cell damage and aging through the damage to proteins, DNA, and other biomolecules. ROS, however, have not been eliminated from our body and we even have the system to generate ROS. This fact may suggest some physiological roles of ROS in our body. In this research, we discovered the important physiological roles of ROS in neuronal plasticity in cerebellum and cerebellum-dependent motor memory by behavioral and electrophysiological experiments.

Academic Significance and Societal Importance of the Research Achievements

抗酸化物質を加えた健康食品が多数市場にあり、抗酸化、抗老化という名の下で人気を集めている。しかし、恒常的なアスコルビン酸摂取が運動能力を低下させる事やその他の抗酸化物質が健康に悪影響を与える事、また、抗酸化物質により除去される活性酸素種がシグナル分子であるという事実は、食品中の抗酸化物質が生体内でROSシグナルに影響を及ぼす可能性も考慮しなければならない事を示唆している。本研究で得られた結果は、活性酸素種が生理活性を有していることを示しており、運動や身体リハビリテーション中の抗酸化物質摂取について再考を求めるものとなった。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (52 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 19 results,  Open Access: 7 results,  Acknowledgement Compliant: 8 results) Presentation (24 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Remarks (4 results)

  • [Int'l Joint Research] University Mainz,/University of Regensburg,/University of Marburg(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of NiceSophia Antipolis(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Centre Scientifique de Monaco(モナコ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Kyungpook National University,(韓国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory2019

    • Author(s)
      Takahashi Keita、Yanai Shuichi、Takisawa Shoko、Kono Nozomu、Arai Hiroyuki、Nishida Yoichiro、Yokota Takanori、Endo Shogo、Ishigami Akihito
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 663 Pages: 120

    • DOI

      10.1016/j.abb.2019.01.003

    • URL

      https://pure.teikyo.jp/en/publications/e6bf0303-b045-48fc-86ff-f8796ae664e5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP attenuates context-dependent fear memory in mice.2019

    • Author(s)
      Kishimoto Y, Kasamatsu S, Yanai S, Endo S, Akaike T, Ihara H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 511 Issue: 1 Pages: 141-147

    • DOI

      10.1016/j.bbrc.2019.01.138

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of Purkinje cell-derived VEGF in cerebellar astrogliosis in Niemann-Pick type C mice2018

    • Author(s)
      Park Min Hee、Lee Ju Youn、Jeong Min Seock、Jang Hyung Sup、Endo Shogo、Bae Jae-sung、Jin Hee Kyung
    • Journal Title

      BMB Reports

      Volume: 51 Issue: 2 Pages: 79-84

    • DOI

      10.5483/bmbrep.2018.51.2.168

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Up-regulation of NSP3 by Oligomeric Aβ Accelerates Neuronal Death Through Cas-independent Rap1A Activation2018

    • Author(s)
      Gomi Fujiya、Uchida Yoko、Endo Shogo
    • Journal Title

      Neuroscience

      Volume: 386 Pages: 182-193

    • DOI

      10.1016/j.neuroscience.2018.06.035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages2018

    • Author(s)
      Bohn T、Rapp S、Luther N、Klein M、Bruehl T-J、Kojima N、Aranda L P、Hahlbrock J、Muth S、Endo S、Pektor S、Brand A、Renner K、Popp V、Gerlach K、Vogel D、Lueckel C、Arnold-Schild D、Pouyssegur J、Kreutz M、Huber M、Koenig J、Weigmann B、Probst H-C、von Stebut E、Becker C、Schild H、Schmitt E、Bopp T
    • Journal Title

      Nature Immunology

      Volume: 19 Issue: 12 Pages: 1319-1329

    • DOI

      10.1038/s41590-018-0226-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] PDE3 Inhibitors Repurposed as Treatments for Age-Related Cognitive Impairment2018

    • Author(s)
      Yanai Shuichi、Endo Shogo
    • Journal Title

      Molecular Neurobiology

      Volume: 印刷中 Issue: 6 Pages: 4306-4316

    • DOI

      10.1007/s12035-018-1374-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term cilostazol administration prevents age-related decline of hippocampus-dependent memory in mice2018

    • Author(s)
      Yanai Shuichi、Ito Hideki、Endo Shogo
    • Journal Title

      Neuropharmacology

      Volume: 129 Pages: 57-68

    • DOI

      10.1016/j.neuropharm.2017.11.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term cilostazol administration ameliorates memory decline in senescence-accelerated mouse prone 8 (SAMP8) through a dual effect on cAMP and blood-brain barrier.2017

    • Author(s)
      Yanai S, Toyohara J, Ishiwata K, Ito H, Endo S.
    • Journal Title

      Neuropharmacology

      Volume: 116 Pages: 246-259

    • DOI

      10.1016/j.neuropharm.2016.12.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The AP-1 transcription factor JunB is required for Th17 cell differentiation2017

    • Author(s)
      Yamazaki Soh、Tanaka Yoshihiko、Araki Hiromitsu、Kohda Akira、Sanematsu Fumiyuki、Arasaki Tomoko、Duan Xuefeng、Miura Fumihito、Katagiri Takaharu、Shindo Ryodai、Nakano Hiroyasu、Ito Takashi、Fukui Yoshinori、Endo Shogo、Sumimoto Hideki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 17402-17402

    • DOI

      10.1038/s41598-017-17597-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] cAMP系増強薬と認知症の治療-既存薬再開発の応用-2017

    • Author(s)
      柳井修一、遠藤昌吾
    • Journal Title

      Geriatric Medicine

      Volume: 5 Pages: 23-26

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Data on the optimization of behavioral tasks for senescence-accelerated mouse prone 8 (SAMP8)2017

    • Author(s)
      S. Yanai and S. Endo
    • Journal Title

      Data in Brief

      Volume: 8 Pages: 262-266

    • DOI

      10.1016/j.dib.2016.05.044

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.2016

    • Author(s)
      Tanahashi, H.;Tian, Q.B.; Hara, Y.;Sakagami, H.;Endo, S.;Suzuki, T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 20241-20241

    • DOI

      10.1038/srep20241

    • NAID

      120007100143

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain2016

    • Author(s)
      Yufune S, Satoh Y, Akai R, Yoshinaga Y, Kobayashi Y., Endo S, Kazama T.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 21859-21859

    • DOI

      10.1038/srep21859

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Early onset of behavioral alterations in senescence-accelerated mouse prone 8 (SAMP8).2016

    • Author(s)
      Yanai S, Endo S.
    • Journal Title

      Behavioural Brain Research

      Volume: in press Pages: 187-195

    • DOI

      10.1016/j.bbr.2016.04.026

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preclinical and the first-in-man studies on [11C]CB184 for imaging 18 kDa translocator protein by positron emission tomography2016

    • Author(s)
      J.Toyohara, M. Sakata, K. Hatano, S. Yanai, S. Endo, K. Ishibashi, K. Wagatsuma, K. Ishii and K. Ishiwata
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 30 Issue: 8 Pages: 534-543

    • DOI

      10.1007/s12149-016-1094-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice.2015

    • Author(s)
      S. Yufune, Y. Satoh, I. Takamatsu, H. Ohta, Y. Kobayashi, Y. Takaenoki, G. Pages, J. Pouyssgur, S. Endo, and T. Kazama.
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 102521-102521

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss2015

    • Author(s)
      Kurioka T, Matsunobu T, Satoh Y, Niwa K, Endo S, Fujioka M, Shiotani A.
    • Journal Title

      Scientific Reports

      Volume: 18;5 Issue: 1 Pages: 16839-16839

    • DOI

      10.1038/srep16839

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired Th2 differentiation of CD4+ T cells from Rap2b knockout mice.2015

    • Author(s)
      Y. Uechi, G. Matsuzaki, M. Suzuki, T. Asato, Kimiko Takei, M. Umikawa, M. Oshiro, I. N. Maruyama, S. Endo and K.-I. Kariya
    • Journal Title

      Ryukyu Med. J.

      Volume: 34 Pages: 45-52

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 巨大地震が飼育動物へ及ぼす影響2015

    • Author(s)
      柳井修一、遠藤昌吾
    • Journal Title

      LABIO21

      Volume: 59 Pages: 20-24

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Knowledge of Signal Transduction Provides an Approach to Attacking Memory Decline.2015

    • Author(s)
      S. Yanai and S. Endo
    • Journal Title

      Aging Mechanisms; Longevity, Metabolism, and Brain Aging (N. Mori, and I. Mook-Jung, Inhee eds)

      Volume: 1 Pages: 257-274

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] Involvement of ROS/8-nitro-cGMP signals in cerebellar synaptic plasticity in mice.2018

    • Author(s)
      S.Kakizawa, S.Endo.
    • Organizer
      World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cilostazol, a phosphodiesterase 3 inhibitor, maintains and improves memory functions in aged mice.2018

    • Author(s)
      S.Yanai, T.Arasaki & S.Endo
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recovery from spatial memory deficits and increase of cerebral glucose uptake in cilostazol-administered aged mice.2018

    • Author(s)
      S.Yanai, T.Tago, J.Toyohara, T.Arasaki & S.Endo.
    • Organizer
      第41回日本基礎老化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The phosphodiesterase 3 inhibitor cilostazol restores memory impairment and enhances cerebral glucose metabolism in aged mice.2018

    • Author(s)
      S.Yanai, T.Tago, J.Toyohara, T.Arasaki & S.Endo
    • Organizer
      日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活性酸素シグナルによる小脳シナプス機能制御2018

    • Author(s)
      柿澤昌、遠藤昌吾
    • Organizer
      生理研研究会「シグナル動態の可視化と操作に基づく多階層機能解析の新展開」
    • Related Report
      2018 Annual Research Report
  • [Presentation] シロスタゾール投与マウスを用いたPRECISEによる行動解析.2017

    • Author(s)
      柳井修一、新崎智子、遠藤昌吾
    • Organizer
      TOBIRA第6回研究交流フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] cAMP系増強薬と記憶障害の治療―既存薬再開発の応用―2017

    • Author(s)
      遠藤昌吾
    • Organizer
      OYC バイオシンポジウム 「老化と加齢性疾患」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cilostazol administration ameliorates the impaired conditioned fear in senescence-accelerated mouse prone 8 (SAMP8).2017

    • Author(s)
      S.Yanai, T.Arasaki, S.Endo.
    • Organizer
      第40回日本基礎老化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cilostazol, a phosphodiesterase 3 inhibitor, improves blood-brain barrier integrity and ameliorates memory decline in senescence-accelerated mouse prone 8 (SAMP8).2017

    • Author(s)
      S.Yanai, J.Toyohara, K.Ishiwata, T.Arasaki S.Endo.
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The effect of 8-nitro-cGMP on SNARE complex assembly and memory2017

    • Author(s)
      Y.Kishimoto, S.Yanai, S.Endo, T.Akaike, H.Ihara.
    • Organizer
      第60回日本神経化学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-ニトロ-cGMPによるホスホジエステラーゼの阻害効果2016

    • Author(s)
      遠藤昌吾、新崎智子、藤井重元、赤池孝章
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cilostazol, a phosphodiesterase 3 inhibitor, as a potential therapeutic target for the treatment of dementia.2016

    • Author(s)
      Shuichi Yanai, Kai Kojima, Tomoko Arasaki & Shogo Endo.
    • Organizer
      31st International Congress of Psychology
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long-term administration of cilostazol, a phosphodiesterase 3 inhibitor, enhances memory functions and cerebral glucose metabolism in aged mice2016

    • Author(s)
      柳井修一・豊原潤・石渡喜一・新崎智子・遠藤昌吾
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Up-regulation of NSP3 by oligomeric Abeta; accelerates neuronal death through Cas-independent Rap1A activation.2016

    • Author(s)
      五味不二也・遠藤昌吾・内田洋子
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 老化促進モデルマウスSAMP8における記憶、学習機能の評価2016

    • Author(s)
      柳井修一・新崎智子・遠藤昌吾
    • Organizer
      第31回SAM研究発表会
    • Place of Presentation
      京都大学芝蘭会館(京都府京都市)
    • Year and Date
      2016-07-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Preclinical and first-in-man studies of imidazopyridineacetamide, [11C]CB184, as a novel 18 kDa translocator protein seeker.2016

    • Author(s)
      Jun Toyohara, Muneyuki Sakata, Kenji Ishibashi, Kei Wagatsuma, Kentaro Hatano, Shuichi Yanai, Shogo Endo, Kenji Ishii and Kiichi Ishiwata.
    • Organizer
      Society of nuclear medicine and molecular imaging 2016 annual meeting
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 老化に伴う認知機能低下に対するシロスタゾールとドネペジルの併用効果2016

    • Author(s)
      柳井修一・新崎智子・遠藤昌吾
    • Organizer
      第39回日本基礎老化学会大会
    • Place of Presentation
      伊勢原市民文化会館(神奈川県伊勢原市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 8-nitro-cGMP on hippocampus-dependent long-term memory in mice.2016

    • Author(s)
      Yusuke Kishimoto, Suhichi Yanai, Shogo Endo, Takaaki Akaike, & Hideshi Ihara.
    • Organizer
      The 9th International Conference on the Bilogy, Chemisty, and Therapeutic Application of Nitric Oxide
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 行動解析を用いたホスホジエステラーゼ3阻害剤シロスタゾールの記憶改善効果の評価2015

    • Author(s)
      柳井修一・新崎智子・遠藤昌吾
    • Organizer
      首都大学東京バイオコンファレンス2015
    • Place of Presentation
      首都大学東京(東京、八王子)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] ATTACKING MEMORY DECLINE THROUGH THE KNOWLEDGE OF SIGNAL TRANSDUCTION PATHWAY2015

    • Author(s)
      S. Endo
    • Organizer
      IAGG2015
    • Place of Presentation
      Chiang Mai International Convention and Exhibition Center(ChiangMai, Thailand)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MP30/αTTP-ダブルノックアウトマウスを用いたアスコルビン酸およびα-トコフェロール欠乏が及ぼ す不安、学習、運動機能への影響2015

    • Author(s)
      高橋経太・柳井修一・下門顕太郎・遠藤昌吾・新井洋由・石神 昭人
    • Organizer
      日本心理学会第79回大会
    • Place of Presentation
      名古屋国際会議場(愛知、名古屋)
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Long-term administration of cilostazol, a phosphodiesterase 3 inhibitor, prevents memory decline in aged mice models.2015

    • Author(s)
      Shuichi Yanai, Kai Kojima, Tomoko Arasaki & Shogo Endo
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際展示場(兵庫、神戸)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 東日本大震災が引き起こしたマウスの行動変化2015

    • Author(s)
      遠藤昌吾
    • Organizer
      第90回実験動物コンファレン
    • Place of Presentation
      日本獣医生命科学大学(東京、武蔵野市)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 老化に伴う認知機能低下に対するホスホジエステラーゼ3阻害剤cilostazolの効果2015

    • Author(s)
      柳井修一・新崎智子・遠藤昌吾
    • Organizer
      第38回日本基礎老化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川、横浜)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Remarks] 記憶神経科学、東京都老人研

    • Related Report
      2018 Annual Research Report
  • [Remarks] Molecular Neurobiology, TMIG

    • URL

      http://www2.tmig.or.jp/Mn_B/English/index.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 記憶神経科学、東京都老人研

    • URL

      http://www2.tmig.or.jp/Mn_B/Japanese/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 記憶神経科学、都老人研

    • URL

      http://www2.tmig.or.jp/Mn_B/Japanese/index.html

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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