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Research on fish scale collagen material technology by field fusion

Research Project

Project/Area Number 15H03526
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials chemistry
Research InstitutionTokyo Institute of Technology

Principal Investigator

Ikoma Toshiyuki  東京工業大学, 物質理工学院, 准教授 (20370306)

Co-Investigator(Kenkyū-buntansha) 田中 利明  東京工業大学, 生命理工学院, 助教 (40263446)
杉山 友明  東京工業大学, 物質理工学院, 助教 (90744178)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords生体外マトリックス / 細胞分泌 / コラーゲン / 遺伝子導入 / 化学修飾 / 分泌経路 / ナノ材料 / 配向構造 / ナノ機能材料 / 階層ナノ構造
Outline of Final Research Achievements

In order to clarify the aligned collagen fibrils and sugar modification of collagen as well as the formation factors of oriented extracellular matrix of collagen fibrils, gradient materials of collagen and hydroxyapatite by electrochemical reaction and the glycosylated collagen using thiolate reaction were succeeded. It was revealed that glycosylation increased the initial adhesion number of fibroblasts. We also established a technique to visualize collagen secretion from cells and clarified that in situ collagen integrity process and in situ measurement of secretion status. By utilizing these technologies, it can be expected to be useful for future scaffolds for regenerative medicine and devices for drug discovery development.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (30 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (17 results) (of which Int'l Joint Research: 6 results,  Invited: 5 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion2018

    • Author(s)
      Kawaguchi Kohei、Endo Akinori、Fukushima Toshiaki、Madoka Yuka、Tanaka Toshiaki、Komada Masayuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 499 Issue: 3 Pages: 635-641

    • DOI

      10.1016/j.bbrc.2018.03.202

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen and Hydroxyapatite Composite Membranes as Drug-Carrying Support for Biomedical Applications2017

    • Author(s)
      Kajiwara Daichi、Ikoma Toshiyuki
    • Journal Title

      MRS Advances

      Volume: 2 Issue: 19-20 Pages: 1083-1088

    • DOI

      10.1557/adv.2017.26

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of hydroxyapatite microparticles including silver nano-dots at grain boundary for long-term antimicrobial property2017

    • Author(s)
      Igashira Hiroaki、Kamo Michimasa、Kyomoto Masayuki、Ikoma Toshiyuki
    • Journal Title

      MRS Advances

      Volume: 2 Issue: 24 Pages: 1285-1290

    • DOI

      10.1557/adv.2016.650

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hierarchical viscosity of aqueous solution of tilapia scale collagen investigated via dielectric spectroscopy between 500MHz and 2.5THz2017

    • Author(s)
      Kawamata H.、Kuwaki S.、Mishina T.、Ikoma T.、Tanaka J.、Nozaki R.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 45398-45398

    • DOI

      10.1038/srep45398

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genes coding for Cyclin-dependent Kinase Inhibitors are Fragile in Xenopus.2017

    • Author(s)
      Toshiaki Tanaka*, Haruki Ochi, Shuji Takahashi, Naoto Ueno, and Masanori Taira.
    • Journal Title

      Developmental Biology

      Volume: 印刷中 Issue: 2 Pages: 30055-0

    • DOI

      10.1016/j.ydbio.2016.06.019

    • NAID

      120006605591

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chondrogenic differentiation of human mesenchymal stem cells on fish scale collagen2016

    • Author(s)
      Oh HH, Uemura T, Yamaguchi I, Ikoma T, Tanaka J
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 122 Pages: 219-225

    • NAID

      40020927683

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of enzymatically cross-linked tilapia scale collagen for osteoblastic differentiation of human mesenchymal stem cells2016

    • Author(s)
      Oh HH, Uemura T, Yamaguchi I, Ikoma T, Tanaka J
    • Journal Title

      Journal of Bioactive and Compatible Polymers

      Volume: 31 Pages: 31-41

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of X-linked protein kinase Nrk during pregnancy triggers breast tumor in mice2016

    • Author(s)
      Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, Inagaki Y, Komada M
    • Journal Title

      Am. J. Pathol.

      Volume: 186 Issue: 10 Pages: 2751-2760

    • DOI

      10.1016/j.ajpath.2016.06.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genome evolution in the allotetraploid frog Xenopus laevis2016

    • Author(s)
      Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A et al.
    • Journal Title

      Nature

      Volume: 538 Issue: 7625 Pages: 336

    • DOI

      10.1038/nature19840

    • NAID

      120006240046

    • URL

      https://pure.teikyo.jp/en/publications/7cb1b606-b88e-4144-9b58-280a85c3c635

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Rapid oriented fibril formation of fish scale collagen facilitates early osteoblastic differentiation of human mesenchymal stem cells2015

    • Author(s)
      Matsumoto R, Uemura T, Xu ZF, Yamaguchi I, Ikoma T, Tanaka J
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 103 Pages: 2531-2539

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] ろこコラーゲン/水酸アパタイト複合膜と 合成ペプチドによる細胞適合性2017

    • Author(s)
      梶原大地、生駒俊之
    • Organizer
      日本セラミックス協会
    • Place of Presentation
      東京
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Xenopus laevis の細胞周期制御因子について2017

    • Author(s)
      田中利明
    • Organizer
      第11回 長野ミーティング:生物資源の有効利用を目指して
    • Place of Presentation
      ラフォーレ倶楽部白馬八方
    • Year and Date
      2017-01-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effect of peptide-loaded artificial periosteum-like membranes on cells2017

    • Author(s)
      Daichi Kajiwara, Toshiyuki Ikoma
    • Organizer
      The Tenth International Conference on the Science and Technology for Advanced Ceramics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hydroxyapatite/collagen membranes laminated with different compositions2017

    • Author(s)
      Daichi Kajiwara, Toshiyuki Ikoma
    • Organizer
      17th Asian BioCeramics Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pre-Magnetic Treatment and Electrolysis Methods as a Novel Strategy to Obtain Collagen-based Bilayer Scaffold2017

    • Author(s)
      Vincent Irawan, Toshiyuki Ikoma
    • Organizer
      日本セラミックス協会 秋季シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] うろこコラーゲンの医療機器への応用展開2017

    • Author(s)
      生駒俊之
    • Organizer
      日本金属学会 秋期講演大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Hydroxyapatite and its related composites for tissue engineering2017

    • Author(s)
      Toshiyuki Ikoma
    • Organizer
      2017 International Symposium of Materials on Regenerative Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fish scale collagen and its composites for tissue engineering2017

    • Author(s)
      Toshiyuki Ikoma
    • Organizer
      2017 International Symposium of Biotechnology on Biomaterials, Stem cells and Tissue Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fabrication of collagen/apatite composites with gradient compositions by electrochemical reaction2016

    • Author(s)
      Sasaki Y and Ikoma T
    • Organizer
      16th AustralasianBioCeramic Symposium
    • Place of Presentation
      Bisbane, Australia
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 母性Cyclin E-DNMT1新規複合体によるツメガエル尾部形成のエピジェネティックな制御2016

    • Author(s)
      田中利明、駒田雅之
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Composite membranes of collagen and hydroxyapatite for drug carrying support2016

    • Author(s)
      Kajiwara D and Ikoma T
    • Organizer
      Materials Research Society 2016 fall meeting
    • Place of Presentation
      ボストン
    • Year and Date
      2016-11-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウロココラーゲンの特徴と複合体の作製2016

    • Author(s)
      生駒俊之
    • Organizer
      日本バイオマテリアル学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of addition of acrylic compounds in apatite/collagen porous composites with gamma-ray irradiation on mechanical and biodegradable properties2016

    • Author(s)
      Minemoto M, Ikoma T
    • Organizer
      TERMIS-AP
    • Place of Presentation
      台湾
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 光るコラーゲンによる肝星細胞の解析2016

    • Author(s)
      田中利明
    • Organizer
      肝胆膵外科学セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2016-06-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Artificial bone based on fish scale collagen2015

    • Author(s)
      Toshiyuki Ikoma
    • Organizer
      Asian BioCeramics Symposium
    • Place of Presentation
      東京
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ポリリン酸/コラーゲン複合線維膜の線維形成能2015

    • Author(s)
      杉山友明, 渡辺玲奈, 生駒俊之
    • Organizer
      第27回日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fish scale collagen and hydroxyapatite nanocomposites for arificial bone2015

    • Author(s)
      Toshiyuki Ikoma and Junzo Tanaka
    • Organizer
      The 5th Asian Bomaterials Congress
    • Place of Presentation
      台湾
    • Year and Date
      2015-05-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 医療に向けた天然高分子2015

    • Author(s)
      生駒俊之, 田中利明
    • Total Pages
      261
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Annual Research Report
  • [Book] ナノバイオとナノメディシン2015

    • Author(s)
      生駒俊之, 田中順三, 伊藤博, 芹澤武, 早乙女進一, 花方信孝, 吉岡朋彦, 沢田敏樹, 多賀谷基博
    • Total Pages
      320
    • Publisher
      コロナ社
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 組成傾斜複合体及びその製造方法2017

    • Inventor(s)
      佐々木祐輔、生駒俊之
    • Industrial Property Rights Holder
      東京工業大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-026377
    • Filing Date
      2017-02-15
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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