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Jisso Technologies for Micro-Nano Medical Devices

Research Project

Project/Area Number 15H03547
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nano/Microsystems
Research InstitutionKeio University

Principal Investigator

MIKI NORIHISA  慶應義塾大学, 理工学部(矢上), 教授 (70383982)

Co-Investigator(Kenkyū-buntansha) 小茂鳥 潤  慶應義塾大学, 理工学部(矢上), 教授 (30225586)
菅野 義彦  東京医科大学, 医学部, 主任教授 (30276232)
Co-Investigator(Renkei-kenkyūsha) MORITA Shinya  慶應義塾大学, 医学部, 助教 (10365364)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywordsマイクロ・ナノ / 医療デバイス / 実装技術 / システム / 生体適合性 / 界面 / マイクロ・ナノデバイス / 医療・福祉 / マイクロマシン / 人工臓器 / マイクロ・ナノ工学 / 医療機器 / インプラント
Outline of Final Research Achievements

Micro/nano technologies can develop implantable and wearable medical devices, such as artificial organs and vital monitoring sensors. To make the micro/nano medical devices to be practically applicable, we consider that "jisso technologies" for micro/nano medical devices need to be developed, which are interface technologies between the device and human and system technologies including treatment procedures and user interface. In this study, we focused on implantable artificial kidney and brain wave measurement system with micro needle electrodes, both of which are enabled by micro/nano technologies. Surface treatment technologies to secure the biocompatibility were experimentally investigated along with the evaluation methods as the interface technology. Protocols to implant the device and fixing mechanisms of the device to the subjects were developed as the system technology. These newly acquired technologies were summarized as the jisso technologies for micro/nano medical devices.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (43 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (31 results) (of which Int'l Joint Research: 18 results,  Invited: 6 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 1 results)

  • [Journal Article] Effect of Cooling Stimulus on Collection Efficiency of Calf Chondrocytes Cultivated on Metal Surface2017

    • Author(s)
      Y. Kurashina, S. Miyata, J. Komotori
    • Journal Title

      International Journal of Automation Technology

      Volume: 11 Issue: 6 Pages: 925-931

    • DOI

      10.20965/ijat.2017.p0925

    • NAID

      130007505840

    • ISSN
      1881-7629, 1883-8022
    • Year and Date
      2017-11-05
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 体内植込み式人工腎臓の現況と未来2017

    • Author(s)
      三木 則尚、菅野義彦
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 5 Pages: 482-487

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Evaluation of biofouling in stainless microfluidic channels for implantable multi-layered dialysis device2017

    • Author(s)
      T. Ota, N. To, Y. Kanno, N. Miki
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 6S1 Pages: 06GN10-06GN10

    • DOI

      10.7567/jjap.56.06gn10

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzyme-free cell detachment mediated by resonance vibration with temperature modulation2017

    • Author(s)
      Yuta Kurashina, Makoto Hirano, Chikahiro Imashiro, Kiichiro Totani, Jun Komotori, Kenjiro Takemura
    • Journal Title

      Biotechnology and Bioengineering

      Volume: 114 Issue: 10 Pages: 2279-2288

    • DOI

      10.1002/bit.26361

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a polymer based fully flexible electrode tip for neuronal micro-stimulation applications2017

    • Author(s)
      R. David, N. Miki
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 印刷中

    • NAID

      210000147927

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Improvement in Wear Resistance of Stainless Steel by Laser-induced Local Surface Treatment2016

    • Author(s)
      A.Ezura, H.Yoshimine, K.Ohkawa, K.Katahira, J.Komotori
    • Journal Title

      Journal of Advanced Mechanical Design, Systems, and Manufacturing

      Volume: 10

    • NAID

      130005266660

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Water-permeable dialysis membranes for multi-layered micro dialysis system2015

    • Author(s)
      N. To, I. Sanada, H. Ito, G.S. Prihanda, S. Morita, Y. Kanno, N. Miki
    • Journal Title

      Frontiers in Bioengineering and Biotechnology

      Volume: 3 Pages: 1-7

    • DOI

      10.3389/fbioe.2015.00070

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Implantable micro/nano medical devices2018

    • Author(s)
      N. Miki, T. Ota, A. Watanabe, Y. Miyaoka, Y. Kanno
    • Organizer
      NMJ2018, 4th International Conference on Nanojoining and Microjoining
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マイクロ・ナノ医療デバイスとしてのインプラント人工腎臓2018

    • Author(s)
      三木則尚
    • Organizer
      日本医工学治療学会第34回学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A precise sampling strip with microstructures2018

    • Author(s)
      H. Kamiya, T. Ota, H. Yasuga, N. Miki
    • Organizer
      EMBC'18, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Blood-separating device without energy source for implantable medical devices2018

    • Author(s)
      H. Otsuki, T. Ota, N. Miki
    • Organizer
      EMBC'18, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enfold-type connecting system of artificial blood vessels for micro implantable dialysis device2018

    • Author(s)
      A. Watanabe, T. Ota, Y. Kanno, N. Miki
    • Organizer
      EMBC'18, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] インプラント人工腎臓の開発2018

    • Author(s)
      三木則尚、大田能士、渡邊 藍、大月斐南子、紙屋はるか、小屋慶彦、菅野慶彦
    • Organizer
      電気学会E部門BMS研究会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment2018

    • Author(s)
      T. Ota, M. Nakayama, Y. Kanno, T. Suzuki, N. Miki
    • Organizer
      MEMS 2018, The 31st IEEE International Conference on Micro Electro Mechanical Systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 患者QOL向上に向けたマイクロ・ナノ医療ならびにヘルスケアデバイス2018

    • Author(s)
      三木 則尚
    • Organizer
      第16回高分子ナノテクノロジー研究会講座
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 血液凝固を防ぐための植込み型無電源血漿分離デバイスの開発2017

    • Author(s)
      大月斐南子、大田能士、三木則尚
    • Organizer
      第8回マイクロ・ナノ工学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] SDラットを対象とした長期凝固能管理とヘパリン投与量の適正化2017

    • Author(s)
      小屋義彦、大田能士、三木則尚
    • Organizer
      第8回マイクロ・ナノ工学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] メンテナンス術式簡略化のための人工血管接続系のコネクタ評価2017

    • Author(s)
      渡邊藍、大田能士、三木則尚
    • Organizer
      第8回マイクロ・ナノ工学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 微細構造を利用したサンプル定量採取ストリップ2017

    • Author(s)
      紙屋はるか、大月斐南子、大田能士、矢菅浩規、三木則尚
    • Organizer
      第8回マイクロ・ナノ工学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] f-DLC-PES膜の製作およびin vitro系血液濾過実験2017

    • Author(s)
      大田能士、中山正光、菅野義彦、鈴木哲也、三木則尚
    • Organizer
      第8回マイクロ・ナノ工学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 無電源血漿分離デバイス2017

    • Author(s)
      大月斐南子、大田能士、三木 則尚
    • Organizer
      電気学会E部門総合研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メンテナンス術式簡略化のための人工血管接続系のコネクタ開発2017

    • Author(s)
      渡邊藍、大田能士、藤本和真、三木則尚
    • Organizer
      ロボティクス・メカトロニクス講演会 ROBOMECH2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] インプラント型人工腎臓のためのチタン製マイクロ流路のin vivo血栓形成評価2017

    • Author(s)
      大田能士、藤直也、菅野義彦、三木則尚
    • Organizer
      ロボティクス・メカトロニクス講演会 ROBOMECH2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Stepping out of the comfort zone2016

    • Author(s)
      N. Miki
    • Organizer
      International Symposium on Micro-Nano Science and Technology 2016
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biofouling of micro dialysis device made of titanium for medium-sized laboratory animals2016

    • Author(s)
      T. Ota, N. To, Y. Kanno, N. Miki
    • Organizer
      International Symposium on Micro-Nano Science and Technology 2016
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Blood separating device without energy resource for implantable applications2016

    • Author(s)
      H. Otsuki, T. Ota, T. Naoya, N. Miki
    • Organizer
      International Symposium on Micro-Nano Science and Technology 2016
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long-term evaluation of biofouling in microfluidic channels for implantable artificial kidney2016

    • Author(s)
      T. Ota, N. To, Y. Kanno, N. Miki
    • Organizer
      29th International Microprocesses and Nanotechnology Conference (MNC2016)
    • Place of Presentation
      Kyoto (Japan)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a fully flexible micro-stimulation electrode tip2016

    • Author(s)
      R. David, N. Miki
    • Organizer
      29th International Microprocesses and Nanotechnology Conference (MNC2016)
    • Place of Presentation
      Kyoto (Japan)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Jisso technology for micro/nano medical devices2016

    • Author(s)
      N. Miki
    • Organizer
      International Conference on Nanojoining and Microjoining 2016
    • Place of Presentation
      Niagara Falls (Canada)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Jisso technology for micro/nano medical devices2016

    • Author(s)
      N.Miki
    • Organizer
      International Confrence on Nanojoining and Microjoining 2016
    • Place of Presentation
      Niagara Falls (Canada)
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of biofouling for implantable micro dialysis system2016

    • Author(s)
      T. Ota, N. To, Y. Kanno, N. Miki
    • Organizer
      IEEE Engineering in Medicine and Biology Conference (EMBC 2016)
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fatigue evaluation using a glass-shape optical sensors system2016

    • Author(s)
      R. Horiuchi, N. Miki
    • Organizer
      IEEE Engineering in Medicine and Biology Conference (EMBC 2016)
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fatigue assessment by electroencephalogram measured with candle-like dry micro-needle electrodes2016

    • Author(s)
      Y. Kudo, M. Arai, N. Miki
    • Organizer
      IEEE Engineering in Medicine and Biology Conference (EMBC 2016)
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A simple method for micropatterning nanofibrous hydrogel film2016

    • Author(s)
      K. Higashi, N. Miki
    • Organizer
      IEEE Engineering in Medicine and Biology Conference (EMBC 2016)
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内における埋め込み型透析装置の長期使用評価2015

    • Author(s)
      藤直也、大田能士、森田伸也、菅野義彦、三木則尚
    • Organizer
      日本機械学会第7回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      朱鷺メッセ(新潟県・新潟市)
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 埋め込み型人工腎臓におけるマイクロ流路のバイオファウリング2015

    • Author(s)
      大田能士、藤直也、森田伸也、菅野義彦、三木則尚
    • Organizer
      日本機械学会第7回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      朱鷺メッセ(新潟県・新潟市)
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 埋め込み型マイクロ透析装置の性能評価2015

    • Author(s)
      藤直也、真田一平、伊藤昴、森田伸也、菅野義彦、三木則尚
    • Organizer
      日本機械学会2015年度年次大会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of implantable hemodialysis system using PES membranes with high-water permeability2015

    • Author(s)
      N. To, I. Sanada, H. Ito, S. Morita, Y. Kanno, N. Miki
    • Organizer
      IEEE Engineering in Medicine and Biology Society (EMBC 2015)
    • Place of Presentation
      Milano (Italy)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] インプラント血液透析装置2018

    • Inventor(s)
      三木則尚、大田能士、渡邊藍
    • Industrial Property Rights Holder
      三木則尚、大田能士、渡邊藍
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-022097
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 医療用チューブの接続装置2017

    • Inventor(s)
      三木則尚、渡邊藍、大田能士
    • Industrial Property Rights Holder
      三木則尚、渡邊藍、大田能士
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-081009
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 血漿分離装置2017

    • Inventor(s)
      三木則尚、藤直也、大田能士、大月斐南子
    • Industrial Property Rights Holder
      三木則尚、藤直也、大田能士、大月斐南子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 血漿分離装置2016

    • Inventor(s)
      三木則尚、藤直也、大田能士、大月斐南子
    • Industrial Property Rights Holder
      三木則尚、藤直也、大田能士、大月斐南子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-12-13
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 血液濾過装置2016

    • Inventor(s)
      菅野義彦、三木則尚
    • Industrial Property Rights Holder
      菅野義彦、三木則尚
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-046355
    • Filing Date
      2016-03-09
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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