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High performance arrayed graphene-based image biosensors

Research Project

Project/Area Number 15H03551
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied materials
Research InstitutionThe University of Tokushima

Principal Investigator

Ohno Yasuhide  徳島大学, 大学院社会産業理工学研究部(理工学域), 准教授 (90362623)

Co-Investigator(Kenkyū-buntansha) 永瀬 雅夫  徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (20393762)
金井 康  大阪大学, 産業科学研究所, 助教 (30721310)
前橋 兼三  東京農工大学, 工学(系)研究科(研究院), 教授 (40229323)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsグラフェン / バイオセンサ / センサ / エピタキシャル
Outline of Final Research Achievements

Biosensing applications based on large-scale, epitaxial graphene film on SiC substrate have been investigated. In the past decade, it have been considered that graphene devices, which were made from conventional mechanical exfoliation and chemical vapor deposition method, can detect solution pH. However, no one can explain why graphene devices can detect solution pH. By using the large-scale, epitaxial graphene film synthesized on a SiC substrate, the electrical characteristics were stable for pH changes. This results indicate that the epitaxial graphene film shows inherent sensing characteristics of graphene. Moreover, from the protein adsorption experiments to the epitaxial graphene film, the charge type of the protein (positive or negative) was independent on the electrical characteristics, indicating the charge transfer from the protein to the graphene film.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (41 results)

All 2018 2017 2016 2015 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (32 results) (of which Int'l Joint Research: 13 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Carrier doping effect of humidity for single-crystal graphene on SiC2017

    • Author(s)
      Makoto Kitaoka, Takuya Nagahama, Kota Nakamura, Takuya Aritsuki, Kazuya Takashima, Yasuhide Ohno, Masao Nagase
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 8 Pages: 085102-085102

    • DOI

      10.7567/jjap.56.085102

    • NAID

      120006489013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ion sensitivity of large-area epitaxial graphene film on SiC substrate2017

    • Author(s)
      Takanori Mitsuno, Yoshiaki Taniguchi, Yasuhide Ohno, Masao Nagase
    • Journal Title

      Applied Physics Letters

      Volume: 111 Issue: 21 Pages: 213103-213103

    • DOI

      10.1063/1.4994253

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamical thermodiffusion model of graphene synthesis on polymer films by laser irradiation and application to strain sensors2017

    • Author(s)
      Kanai Yasushi、Ishibashi Yusuke、Ono Takao、Inoue Koichi、Ohno Yasuhide、Maehashi Kenzo、Matsumoto Kazuhiko
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7 Pages: 075102-075102

    • DOI

      10.7567/jjap.56.075102

    • NAID

      210000148001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperature dependence of universal conductance fluctuation due to development of weak localization in graphene2017

    • Author(s)
      Terasawa D.、Fukuda A.、Fujimoto A.、Ohno Y.、Matsumoto K.
    • Journal Title

      Solid State Communications

      Volume: 267 Pages: 14-17

    • DOI

      10.1016/j.ssc.2017.09.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of hydrophilic graphene film by molecular functionalization2017

    • Author(s)
      Yoshiaki Taniguchi, Tsubasa Miki, Takanori Mitsuno, Yasuhide Ohno, Masao Nagase, Keiji Minagawa, Mikito Yasuzawa
    • Journal Title

      Phys. Status Solidi B

      Volume: 254 Pages: 1600524-1600524

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glycan-functionalized graphene-FETs toward selective detection of human-infectious avian influenza virus2017

    • Author(s)
      Takao Ono
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 3 Pages: 030302-030302

    • DOI

      10.7567/jjap.56.030302

    • NAID

      210000147449

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Top-gated graphene field-effect transistors by low-temperature synthesized SiNx insulator on SiC substrates2016

    • Author(s)
      Y. Ohno, Y.i Kanai, Y. Mori, M. Nagase, K. Matsumoto
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55

    • NAID

      210000146619

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Utilizing research into electrical double layers as a basis for the development of label-free biosensors based on nanomaterial transistors2016

    • Author(s)
      K. Maehashi, Y. Ohno, K. Matsumoto
    • Journal Title

      Nanobiosensors in Disease Diagnosis

      Volume: 5 Pages: 1-13

    • DOI

      10.2147/ndd.s40316

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] イミノビオチン修飾グラフェンによるアビジン吸着特性の pH 制御2018

    • Author(s)
      谷口 嘉昭、三木 翼、大野 恭秀、永瀬 雅夫、荒川 幸弘、今田 泰嗣、南川 慶二、安澤 幹人
    • Organizer
      第65回応用物理学会春期学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] SiC上グラフェンへの水ドーピング効果の評価2018

    • Author(s)
      寺谷 仁志、北岡 誠、松井 一史、田原 雅章、大野 恭秀、永瀬 雅夫
    • Organizer
      第65回応用物理学会春期学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Vertically stacked graphene tunneling junction with insulative water layer2018

    • Author(s)
      Du Jiyao、Yukinobu Kimura、Masaaki Tahara、Kazushi Matsui、Hitoshi Teratani、Yasuhide Ohno、Masao Nagase
    • Organizer
      第65回応用物理学会春期学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多チャンネルグラフェンFETによるインフルエンザウイルス検出2018

    • Author(s)
      黒松 亜紀、小野 尭生、牛場 翔太、金井 康、谷奥 正巳、川田 拓哉、大野 恭秀、前橋 兼三、井上 恒一、渡邊 洋平、中北 愼一、河原 敏男、鈴木 康夫、木村 雅彦、松本 和彦
    • Organizer
      第65回応用物理学会春期学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グラフェンFET上でのインフルエンザウイルス/抗体結合のウレアーゼ反応による検出2018

    • Author(s)
      山本 佳織、小野 尭生、牛場 翔太、金井 康、谷奥 正巳、大野 恭秀、前橋 兼三、井上 恒一、渡邊 洋平、中北 愼一、河原 敏男、鈴木 康夫、木村 雅彦、松本 和彦
    • Organizer
      第65回応用物理学会春期学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロウェルと複合化したグラフェントランジスタを用いたインフルエンザウイルスのヒト感染性と亜型の鑑別2018

    • Author(s)
      山中 天志、白井 充、小野 尭生、牛場 翔太、金井 康、谷奥 正巳、大野 恭秀、前橋 兼三、井上 恒一、渡邊 洋平、中北 愼一、河原 敏男、鈴木 康夫、木村 雅彦、松本 和彦
    • Organizer
      第65回応用物理学会春期学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 集束イオンビームを用いたステンシルリソグラフィ技術のためのSub10nmパターンの作製2017

    • Author(s)
      朴 理博、永瀬 雅夫、大野 恭秀
    • Organizer
      第64回応用物理学会春期学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] SiC上グラフェンの水吸着によるキャリア密度変化2017

    • Author(s)
      北岡 誠、永濱 拓也、中村 晃大、有月 琢哉、高嶋 和也、大野 恭秀、永瀬 雅夫
    • Organizer
      第64回応用物理学会春期学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分子修飾機能化によるSiC上グラフェンの非特異吸着の抑制2017

    • Author(s)
      谷口 嘉昭、三木 翼、光野 琢仁、大野 恭秀、永瀬 雅夫、南川 慶二、安澤 幹人
    • Organizer
      第64回応用物理学会春期学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Electrical characteristics of positively and negatively charged protein adsorption to epitaxial graphene film on SiC substrate2017

    • Author(s)
      Yasuhide Ohno, Taniguchi Yoshiaki, Masao Nagase
    • Organizer
      2017 Workshop on Innovative Nanoscale Devices and Systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ホスホリルコリン修飾グラフェンのタンパク質吸着特性2017

    • Author(s)
      谷口 嘉昭、三木 翼、大野 恭秀、永瀬 雅夫、荒川 幸弘、今田 泰嗣、南川 慶二、安澤 幹人
    • Organizer
      第9回集積化MEMSシンボジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Water adsorption and desorption for graphene on SiC2017

    • Author(s)
      Makoto Kitaoka, Kota Nakamura, Hitoshi Teratani, Yasuhide Ohno, Masao Nagase
    • Organizer
      International Symposium on Epitaxial Graphene 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intrinsic response of protein adsorption to graphene film on SiC substrate2017

    • Author(s)
      Yoshiaki Taniguchi, Tsubasa Miki, Yasuhide Ohno, Masao Nagase, Yukihiro Arakawa, Yasushi Imada, Keiji Minagawa, Mikito Yasuzawa
    • Organizer
      2017 International Conference on Solid State Devices and Materials
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SiC グラフェンを用いた親水化処理における修飾分子依存性2017

    • Author(s)
      杉岡 賢人, 谷口 嘉昭, 三木 翼, 田原 雅章, 大野 恭秀, 永瀬 雅夫, 荒川 幸弘, 南川 慶二, 今田 泰嗣, 安澤 幹人
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ケルビンフォース顕微鏡を用いた SiC 上グラフェン構造水層の観察2017

    • Author(s)
      松井 一史, 中村 晃大, 北岡 誠, 谷口 嘉昭, 大野 恭秀, 永瀬 雅夫
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Intrinsic ion sensitivity of graphene field-effect transistors2016

    • Author(s)
      Yasuhide Ohno, Takanori Mitsuno, Yoshiaki Taniguchi, and Masao Nagase
    • Organizer
      2016 Workshop on Innovative Nanoscale Devices and Systems
    • Place of Presentation
      Hapuna Beach Prince Hotel(HI, USA)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristics on Bare and Phosphorylcholine-Modified Graphene Film on SiC Substrate2016

    • Author(s)
      Yoshiaki Taniguchi, Tsubasa Miki, Takanori Mitsuno, Yasuhide Ohno, Masao Nagase, Keiji Minagawa, and Mikito Yasuzawa
    • Organizer
      29th International Microprocesses and Nanotechnology Conference
    • Place of Presentation
      ANA Crowne Plaza(京都府京都市)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Carrier Doping Effect of Humidity for Single-Crystal Graphene on SiC2016

    • Author(s)
      M. Kitaoka, T. Nagahama, K. Nakamura, T. Aritsuki, K. Takashima, Y. Ohno and M. Nagase
    • Organizer
      29th International Microprocesses and Nanotechnology Conferen
    • Place of Presentation
      ANA Crowne Plaza(京都府京都市)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グラフェン本来のイオンセンシング特性2016

    • Author(s)
      大野 恭秀、光野 琢仁、谷口 嘉昭、永瀬 雅夫
    • Organizer
      第77回応用物理学会秋期学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 走査プローブ顕微鏡を用いたSiC上グラフェンの実効ヤング率計測2016

    • Author(s)
      山田 祐輔、有月 琢哉、高嶋 和也、大野 恭秀、永瀬 雅夫
    • Organizer
      第77回応用物理学会秋期学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 顕微ラマン分光法によるSiC上グラフェンの応力とキャリア密度の面内分布評価2016

    • Author(s)
      森本 征士、有月 琢哉、青木 翔、大野 恭秀、永瀬 雅夫
    • Organizer
      第77回応用物理学会秋期学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] グラフェン電界効果トランジスタ上に捕捉した酵素分子の高感度検出2016

    • Author(s)
      小野 尭生、金井 康、大野 恭秀、前橋 兼三、井上 恒一、松本 和彦
    • Organizer
      第77回応用物理学会秋期学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] SiC上グラフェンの水脱離による導電率変化2016

    • Author(s)
      北岡 誠、永濱 拓也、中村 晃大、有月 琢哉、高嶋 和也、大野 恭秀、永瀬 雅夫
    • Organizer
      第77回応用物理学会秋期学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] [講演奨励賞受賞記念講演] 糖鎖機能化グラフェンFETを用いた抗ウイルス薬効評価のためのノイラミニダーゼ反応計測2016

    • Author(s)
      鎌田 果歩、小野 尭生、金井 康、大野 恭秀、前橋 兼三、井上 恒一、渡邊 洋平、河原 敏男、鈴木 康夫、中北 愼一、松本 和彦
    • Organizer
      第77回応用物理学会秋期学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Hydrophilic Graphene Film by Molecular Functionalization2016

    • Author(s)
      Yoshiaki Taniguchi, Tsubasa Miki, Takanori Mitsuno, Yasuhide Ohno, Masao Nagase, Keiji Minagawa, and Mikito Yasuzawa
    • Organizer
      The 43rd International Symposium on Compound Semiconductors
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intrinsic pH Sensitivity of Graphene Field-Effect Transistors2016

    • Author(s)
      Takanori Mitsuno, Yoshiaki Taniguchi, Yasuhide Ohno, and Masao Nagase
    • Organizer
      The 43rd International Symposium on Compound Semiconductors
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Top-Gated Graphene Field-Effect Transistors by Low-Temperature Synthesized SiNx Insulator on SiC Substrates2015

    • Author(s)
      Y. Ohno, M. Nagase, K. Matsumoto
    • Organizer
      28th International Microprocesses and Nanotechnology Conference
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrical Detection of Polymerase Chain Reaction Using Graphene Field-Effect Transistors2015

    • Author(s)
      M. Okano, S. Norhayati, V. Rajiv, T. Ono, Y. Kanai, Y. Ohno, K. Maehashi, K. Inoue, F. Takei, K. Nakatani, K. Matsumoto
    • Organizer
      28th International Microprocesses and Nanotechnology Conference
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Position-Controlled Graphene Growth Using Micropatterning on Catalytic Copper Surface2015

    • Author(s)
      Y. Mori, T. Ikuta, T. Ono, Y. Kanai, Y. Ohno, K. Maehashi, K. Inoue, K. Matsumoto
    • Organizer
      28th International Microprocesses and Nanotechnology Conference
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cat-CVD法によるSiNx絶縁膜を用いたSiCグラフェンFETの作製2015

    • Author(s)
      大野恭秀、永瀬雅夫、松本和彦
    • Organizer
      第76回応用物理学関係連合講演会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Control of charging energy in carbon nanotube single electron transistor by electric-double-layer gate with ionic liquid2015

    • Author(s)
      K. Kamada, Y. Kanai, Y. Ohno, K. Maehashi, K. Inoue, K. Matsumoto
    • Organizer
      Advanced Materials World Congress
    • Place of Presentation
      Stocholm, Sweeden
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Graphene Synthesis on Polymer Films and its Application to Flexible Devices2015

    • Author(s)
      Y. Ishibashi, Y. Kanai, T. Ono, Y. Ohno, K. Maehashi, K. Inoue, K. Matsumoto
    • Organizer
      73rd Device Research Conference
    • Place of Presentation
      Ohio, USA
    • Year and Date
      2015-06-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 永瀬・大野研究室 科研費報告

    • URL

      http://graphene.ee.tokushima-u.ac.jp/kaken.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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