| Budget Amount *help |
¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We have been examining the radio-adaptive response induced in the cells pre-irradiated cytoplasm with low-LET electromagnetic radiations. The cytoplasm of all cells captured by the computerized irradiation system was irradiated with 10R first, and then the cell nucleus of all cells captured was irradiated with 10R at the 3hr interval, within which the cells were kept in a CO2 incubator at 37oC. Cell-killing effect was measured with a colony-forming assay as a reproductive dell death. The surviving fraction for the targeted cell nucleus irradiation alone was around 0.80 and no cell-killing effect was induced by the targeted cytoplasm irradiation alone. The surviving fraction in the cells irradiated with the targeted cell nuclei when irradiated the cytoplasm beforehand was increased at 0.96. The obtained results clearly suggest that the radio-adaptive response should occur in the cells pre-irradiated to cytoplasm with the X-ray microbeams.
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