| Project/Area Number |
15H03708
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Ryoichi 京都大学, 大学院工学研究科, 教授 (10263401)
MOLINA John 京都大学, 大学院工学研究科, 助教 (20727581)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | ソフトマター物理 / 脂質膜 / 自発曲率 / 計算物理 / ソフトマター物理学 / 統計力学 / シグナル伝達 / 脂質 / ミクロ相分離 |
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| Outline of Final Research Achievements |
In this study, to clarify the physical mechanism behind bio-membrane functions in response to an external stimulus, we have addressed the two following questions: (1) how a chemical substance (local stimulus) induces a change in the membrane dynamics and (2) how a specific chemical concentration field (global stimulus) can induce large length- and long-time scale shape deformations. In the study of the membrane response to a local stimulus, we found that the competition between local composition fluctuations and the interaction between the lipid-composition and stimulated Glycosyl-Phosphatidyl-Inositol Anchored Receptors (GPI-AR) is the key factor to determine the formation of GPI clusters and the temporal domain of the lipids. Regarding to the membrane deformation by a global stimulus (i.e., an injection of NaOH-aq. solution), we found that the ion transport by convection and diffusion controls the membrane deformation dynamics.
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